1EG3,8YT8


Conserved Protein Domain Family
EF-hand_3

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pfam09069: EF-hand_3 (This model is not part of the current CDD release)
EF-hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.
Statistics
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PSSM-Id: 518670
Aligned: 20 rows
Threshold Bit Score: 117.039
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1EG3_A       166 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGsnIEPSVRSCFQFan--nKPEIEA-----ALFLD 238 human
Q0E9B2       135 LVDKLRYIFSQISDGAGQLVAWKLGEFLREVLALPAAVYESPTFHY--KEGLEEEIFPA-----ENKVTV-----NDFMA 202 fruit fly
Q9Y4J8       144 IMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGY--TEQSARSCFSQ-----QKKVTL-----NGFLD 211 human
NP_001074050 144 ILDKLRYIFSQISDPNGLMIYSQFDQFLREVLKVPVSVFEGPSFGY--TEQSTRSCFPQ-----EKKVTL-----NVFLD 211
Q8K0N0       144 MLDKLRYIFSQMSDSNGLMMFGKLDQFLKEALKLPTAVFEGPSFGY--TEHAVRTCFPQ-----QKKIML-----NMFLD 211 house mouse
Q9Y048       165 LVDKLRYIFSQIADSNGLMDHIKFTDFLQQILSLTTAVFEAPTFGF--SENAVNQCFHK-----DEKVSL-----NVFLD 232 Caenorhabditis ...
EDO47831     120 LVDKLRYHFSQIEDNNGMLNFPKFEAYLRELLQLPASVGEAPTFGF--TEDVASIFFKPqgpldRQRTQL-----VHFLE 192
EDO45067     138 LQDKYRYLFRQMCNSRAVLDRKRLTLFLQECLQIPKYIYESTIFSGtsVEPAVKNCFETvs--fTYTLEVelqkfKSFME 215
Q1RL59       141 LVKKYKLLFSLYSGSLRMLTRSRCGLMLAHCVRLTDVVGEDINFGN--ISSAIASCFSGv---lGASISE-----QQLLQ 210 vase tunicate
8YT8_C       113 IMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGY--TEQSARSCFSQ-----QKKVTL-----NGFLD 180 house mouse
1EG3_A       239 WMRLE--PQSMVWLPVLHRVA 257 human
Q0E9B2       203 TLMSEpgPSCLVWLPLVHRLA 223 fruit fly
Q9Y4J8       212 TLMSDppPQCLVWLPLLHRLA 232 human
NP_001074050 212 TFMSDppPQCLVWLPLMHRLA 232
Q8K0N0       212 TMMADppPQCLVWLPLMHRLA 232 house mouse
Q9Y048       233 TFLSDpcPPCIMWLPLLHRMA 253 Caenorhabditis elegans
EDO47831     193 CVMNKepPPPYAWLSTLQKMN 213
EDO45067     216 WMVAE--PQTIVWLPTLHRLA 234
Q1RL59       211 WLFKE--PQSLVWLPTMHRLN 229 vase tunicate
8YT8_C       181 TLMSDppPQCLVWLPLLHRLA 201 house mouse
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