1EG3


Conserved Protein Domain Family
EF-hand_3

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pfam09069: EF-hand_3 
EF-hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.
Statistics
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PSSM-Id: 401129
View PSSM: pfam09069
Aligned: 23 rows
Threshold Bit Score: 115.855
Threshold Setting Gi: 156630438
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1EG3_A       166 LEDKYRYLFKQV-------ASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGsnIEPSVRSCFQFAnNKPEIEA----- 233
Q0E9B2       135 LVDKLRYIFSQI-------SDGAGQLVAWKLGEFLREVLALPAAVYESPTFHY--KEGLEEEIFPA---ENKVTV----- 197 fruit fly
Q9Y4J8       144 IMDKLRYIFSMI-------SDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGY--TEQSARSCFSQ---QKKVTL----- 206 human
ABF55374     144 ILDKLRYIFSQI-------SDPNGLMIYSQFDQFLREVLKVPVSVFEGPSFGY--TEQSTRSCFPQ---EKKVTL----- 206 zebrafish
Q8K0N0       144 MLDKLRYIFSQM-------SDSNGLMMFGKLDQFLKEALKLPTAVFEGPSFGY--TEHAVRTCFPQ---QKKIML----- 206 house mouse
Q9Y048       165 LVDKLRYIFSQI-------ADSNGLMDHIKFTDFLQQILSLTTAVFEAPTFGF--SENAVNQCFHK---DEKVSL----- 227 Caenorhabditis ...
XP_001637130 138 LQDKYRYLFRQM-------CNSRAVLDRKRLTLFLQECLQIPKYIYESTIFSGtsVEPAVKNCFETVsFTYTLEVelqkf 210 starlet sea ane...
A2CI97       122 LSAKQRALFRLAesysgnqESDRGSISRSALRVLLEDLSQVPAVVQENHVFGH--AETAVSSCFNGV-ISAGVTE----- 193 zebrafish
Q1RL59       141 LVKKYKLLFSLY-------SGSLRMLTRSRCGLMLAHCVRLTDVVGEDINFGN--ISSAIASCFSGV-LGASISE----- 205 vase tunicate
CAF87389      24 LVDKLRYVFSQV-------SDSNGVLVQSKFDAFLREALKLPTAVYEGPSFGY--AQASTRPCFPQ---QKRVTV----- 86  spotted green p...
1EG3_A       234 ALFLDWMRLE--PQSMVWLPVLHRVA 257
Q0E9B2       198 NDFMATLMSEpgPSCLVWLPLVHRLA 223 fruit fly
Q9Y4J8       207 NGFLDTLMSDppPQCLVWLPLLHRLA 232 human
ABF55374     207 NVFLDTFMSDppPQCLVWLPLMHRLA 232 zebrafish
Q8K0N0       207 NMFLDTMMADppPQCLVWLPLMHRLA 232 house mouse
Q9Y048       228 NVFLDTFLSDpcPPCIMWLPLLHRMA 253 Caenorhabditis elegans
XP_001637130 211 KSFMEWMVAE--PQTIVWLPTLHRLA 234 starlet sea anemone
A2CI97       194 EHFIWWLQSE--PRLLLWLSTLYRIS 217 zebrafish
Q1RL59       206 QQLLQWLFKE--PQSLVWLPTMHRLN 229 vase tunicate
CAF87389      87 NMFLDILEDP--PQCLVWLPLIHRLA 110 spotted green pufferfish
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