1EG3


Conserved Protein Domain Family
EF-hand_2

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pfam09068: EF-hand_2 
EF hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.
Statistics
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PSSM-Id: 401128
View PSSM: pfam09068
Aligned: 55 rows
Threshold Bit Score: 93.3483
Threshold Setting Gi: 242001266
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1EG3_A        45 ELYQSL-ADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLK-----QNDQPMDILQIINCLTTIYdr--l 116
XP_002022772  36 AIMEKLqVDYGKYKYTVYRCASKFVALQKIFHTSKIPYKLVLAILERHGMPassgsNLNLMVPPFQLTSLLHDIYfacek 115 Drosophila pers...
XP_001963840  47 SIIDELqMKYGNYKYTVYRCASKFVALQKIFHTGKVPYKLVLAILERHGLRg----NLELMVPPFQLTSLIHDIYfacek 122 Drosophila anan...
Q24175        45 TIMDDLqRDYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDRHNLSg----GLELMVPPFQLTSLLHDVYfacek 120 fruit fly
Q7QHZ2        12 filltinEKYAGARYSTYRCAGKLHALQKALHTSYIPFEMVHSILNRHQLNl---iDSAPSIKPGQLASVVHDVYfaaar 88  Anopheles gambi...
EDS33044      31 yILNKInEKFATSKYSTYRCACKLFALQKALFTNYIPFQTICTILERHRLNq---iDSAPSIKPSQLTAVLHDVYfaaeq 107 southern house ...
XP_012058338   3 NIMRSM-QECNAIRYPSYRTAAKMQILHRELNMTHVQLELIAGVFERHRLSi---tENCVNLDPSEIEDVLSDIYf---- 74  Atta cephalotes
9_pfamImport   2 QILEDV-QSCNCIRYAAYRTAAKLDILQKNLGLDRVGLTLIKRVFEQHKILs---tDLYLTLSEQELEDILYDIFf---- 73 
KYB26277      34 ELKHTI-DDWNYVKYSKYRVGLKFRALQKALFMEEVTLSTVMGVFAKHKLGm---nESSLCLESYDLEAVLYDIFf---- 105 red flour beetle
OWR55309      35 KILKTL-DEYNDIKYSAYRIAFKIFALQRSLKVPPLRISS--GVFARHQLSl---sETSLSLDTAELEAVLADIYf---- 104 Danaus plexippu...
1EG3_A       117 eQEHNN--LV-NVPLCVDMCLNWLLNVYD------TGRTGRIRVLSFKTGIISL 161
XP_002022772 116 lGHFTKtsSY-TLETATALLANFFWNIYD------PQRRHSISLLEIRVTFLLL 162 Drosophila persimilis
XP_001963840 123 lGHFAQesSF-QLETASELLANFFWNVYD------PQRRHSISLLEIKITLILF 169 Drosophila ananassae
Q24175       121 lGHFNQdaNY-KLDRATGLLANFFWNVYD------PQRRHSISLLEIRITFILL 167 fruit fly
Q7QHZ2        89 mGYFDElpARpNLDAASALLAGFLWAVFD------PKRTTPVSVLELRQAFLLL 136 Anopheles gambiae str. PEST
EDS33044     108 lGYFAEltQQpDRDALISTLAGLLWSVFD------PKRCNPLSVLELKQTFLLL 155 southern house mosquito
XP_012058338  75 aAQKESnfNF-DVDLVTKLATNYILNTFD------KQNTGNILVFSVKVALVLL 121 Atta cephalotes
9_pfamImport  74 aTSKVLtrPF-DINLSVSLTKYFLTNVCQstknefNTTDNKITVFEAKASIVLL 126
KYB26277     106 aANKRNnkNI-DVDFAVELMQNFLYNIYD------KERQVKIQVSSTKLALALL 152 red flour beetle
OWR55309     105 aAEKEGlfTG-DVDLSVDLLINLLLNVYD------GERKSPIRVLAAKTLLILL 151 Danaus plexippus plexippus
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