1EG3,9C3C


Conserved Protein Domain Family
EF-hand_2
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pfam09068: EF-hand_2 (This model is not part of the current CDD release)
EF hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.
Links
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Statistics
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PSSM-Id: 518669
Aligned: 42 rows
Threshold Bit Score: 100.306
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1EG3_A         44 TELYQSL-ADLNNVRFSAYRTAMKLRRLQKAL----------------------------------CLDLLSLSAACDAL 88  human
EEC08100       52 VAIMDKL-TSFNDIKYAAYRTGAKLICLQKELlreqhcstkglssspgvhpvptddyhafrgalspAVSNVHVSMLPGVF 130
XP_012058338    2 ENIMRSM-QECNAIRYPSYRTAAKMQILHREL----------------------------------NMTHVQLELIAGVF 46 
14_pfamImport   1 KQILEDV-QSCNCIRYAAYRTAAKLDILQKNL----------------------------------GLDRVGLTLIKRVF 45 
KYB26277       33 IELKHTI-DDWNYVKYSKYRVGLKFRALQKAL----------------------------------FMEEVTLSTVMGVF 77 
XP_001851098   30 TYILNKInEKFATSKYSTYRCACKLFALQKAL----------------------------------FTNYIPFQTICTIL 75 
XP_001963840   46 ASIIDELqMKYGNYKYTVYRCASKFVALQKIF----------------------------------HTGKVPYKLVLAIL 91 
Q24175         44 STIMDDLqRDYGNYKYTVYRCASKFVALQKIF----------------------------------HTGKIPYKLVLAIL 89  fruit fly
XP_032519961   34 SKILKTL-DEYNDIKYSAYRIAFKIFALQRSL----------------------------------KVPPLRISS--GVF 76 
XP_046444099   10 RELLAAL-NQFANIRYVAYRTAAKLKFIQSQT----------------------------------KLDCIKLTQIFRII 54 

1EG3_A         89 DQHNLK---QNDQPMDILQIINCLTTIYdr--leQEHNN--LV-NVPLCVDMCLNWLLNVYD------TG-RTGRIRVLS 153 human
EEC08100      131 GCRGLEgsgQQELLLGCSQAEAVLEELY------RRAPGvhQQ-KVPLLAALALNLLQNLFD------AK-RKGTIQVVQ 196
XP_012058338   47 ERHRLSi-tENCVNLDPSEIEDVLSDIYf----aAQKESnfNF-DVDLVTKLATNYILNTFD------KQ-NTGNILVFS 113
14_pfamImport  46 EQHKILs-tDLYLTLSEQELEDILYDIFf----aTSKVLtrPF-DINLSVSLTKYFLTNVCQstknefNT-TDNKITVFE 118
KYB26277       78 AKHKLGm-nESSLCLESYDLEAVLYDIFf----aANKRNnkNI-DVDFAVELMQNFLYNIYD------KE-RQVKIQVSS 144
XP_001851098   76 ERHRLNq-iDSAPSIKPSQLTAVLHDVYfaaeqlGYFAEltQQpDRDALISTLAGLLWSVFD------PK-RCNPLSVLE 147
XP_001963840   92 ERHGLRg--NLELMVPPFQLTSLIHDIYfaceklGHFAQesSF-QLETASELLANFFWNVYD------PQ-RRHSISLLE 161
Q24175         90 DRHNLSg--GLELMVPPFQLTSLLHDVYfaceklGHFNQdaNY-KLDRATGLLANFFWNVYD------PQ-RRHSISLLE 159 fruit fly
XP_032519961   77 ARHQLSl-sETSLSLDTAELEAVLADIYf----aAEKEGlfTG-DVDLSVDLLINLLLNVYD------GE-RKSPIRVLA 143
XP_046444099   55 DEFGLRs-sEKDLILTMDEIRQMVLNIYf----lAQKSQlvHL-DYKVSSRIVLDLISETFD------KScRKKGCTLLD 122

1EG3_A        154 FKTGIISLC 162 human
EEC08100      197 MKVALFVLC 205
XP_012058338  114 VKVALVLLC 122
14_pfamImport 119 AKASIVLLC 127
KYB26277      145 TKLALALLS 153
XP_001851098  148 LKQTFLLLC 156
XP_001963840  162 IKITLILFC 170
Q24175        160 IRITFILLC 168 fruit fly
XP_032519961  144 AKTLLILLS 152
XP_046444099  123 FLVFFTILC 131
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