1E42


Conserved Protein Domain Family
B2-adapt-app_C

?
pfam09066: B2-adapt-app_C 
Beta2-adaptin appendage, C-terminal sub-domain
Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerization. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).
Statistics
?
PSSM-Id: 401126
View PSSM: pfam09066
Aligned: 91 rows
Threshold Bit Score: 60.7296
Threshold Setting Gi: 144577662
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1E42_A       148 VEDGKMERQVFLATWKDIPNENELQFQIKEchlNADTVSSKLQNNNVYTIAkRnv-egQDMLYQSL---KLTNGIWILAE 223
XP_007485236 620 VPNGQLTAEQFEKTWLSLEVAHQEVLPWQGv-aHPDTIQTALQMVNIQTIAlSkagvqPWKAYLSA---QDGSGCVFLTE 695 gray short-tail...
XP_023417009 621 IPNCQFTAEYFEKTWLSLEVAHQQILPWQGe-vHPDTLQMALQVVNIQTIAmSrvgaqPWKAYLSA---QDATGCLFLTE 696 domestic guinea...
XP_008108063 622 mpSVCLTAEQFERTWINLDVGCQQSVPWQEm-vPPDAIQAALQVVHIQTIAmSkagsqLWKAYLAA---QDDTGCLFLTE 697 green anole
XP_027300885 622 IPDVYLTAEQFEKTWLSLDISCQHSLPWGRt-vHPDTIQTAFHVVHIHTIAmSkagvqPWKAYFSA---QDDTGCLFLTE 697 mallard
XP_016159720 530 IPDVSLTAEQFEKSWLSLDTSCQLSLPWCGs-vHADTIQTALRVVHIQTIAmSkagaqPWKAYLSA---QDDSGCLFLTE 605 Collared flycat...
XP_015197619 607 ntvPALSPELFEKRWLELESAHIQTLACRQpgsSPETLQAALQLVKIQTLAfSrpgarPWKAYLYT----YSSDTLVLAE 682 spotted gar
5_pfamImport   1 ---PALSPEEFERLWTQRRAPPAESVPLHGt-sSPQSLQAAMQLVNIQTLAfTaahasPWRVYLYThaqQAARSALILGQ 76 
NP_956632    612 cagAAVSPEAFEQMWQQLEVLQRQTVCFSGc--AADTLQSALQPVHIQTLAfSparalPWRAYIYS----RGSGTLVLAE 685 zebrafish
BAB22515     114 VPNLQLTAEYFEKTWLSLRVSYQQVFPWQGe-vQPDTLQMALKVVNIQTIAmSragaqPWKAYLSA---QDDTGGLFLAE 189 house mouse
1E42_A       224 LRIQPGNp--nYTLSLKCR--APEVSQYIYQVYDSI 255
XP_007485236 696 LLLDPEHl--qVRLSVKQShvKAEALNSFISVLKTV 729 gray short-tailed opossum
XP_023417009 697 LLLE-PGns-kMQISVKQSetRTEILSRFISVLETV 730 domestic guinea pig
XP_008108063 698 LLLEIGGi--eIQMLVKQSdnKPEVLQAFVSVLKTV 731 green anole
XP_027300885 698 LLLETEDs--eMQVSVKQSeaKPEALQAFMSVFRTA 731 mallard
XP_016159720 606 LLLQAADs--eLQVSVKQNeaKPEALQSFISALRTV 639 Collared flycatcher
XP_015197619 683 LTWDADPgaadLSVTLKQDpkDEEALNGVVLVLQTV 718 spotted gar
5_pfamImport  77 LLYAGREe--eVKVTLKQRprDEKALQGFLSILTAV 110
NP_956632    686 LLQDDPEm---LTVTIKQQpeHQQTVTAFISVLQSV 718 zebrafish
BAB22515     190 LLLKPENs--eMQISVKQSkaRTESLHGFVSVLETV 223 house mouse
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap