Conserved Protein Domain Family
B2-adapt-app_C

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pfam09066: B2-adapt-app_C (This model is not part of the current CDD release)
Beta2-adaptin appendage, C-terminal sub-domain
Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15).
Statistics
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PSSM-Id: 518667
Aligned: 85 rows
Threshold Bit Score: 59.9745
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002947067  724 NPKARVAAGAFQEEWKRLT-PAHCSTLSVSPATvAAivaNNHRDFTQHMTQAYIHTIA-SGG--QApSFRYYFYG---QN 796 
XP_001323783  740 ESMGRMTKAVFAEQIETLD-PRPKPCITVPS---SVl--NSANDAREFLNGKNLCFLGkQ-------GECTFFTA---MA 803 
A0CBT3       1031 SSTASITQQKFIELSQAQNqARKQEVLQIQI---------DPQRMKEKLERNYFFLIGvRKD--ERgVELLSYAA---SL 1096 Paramecium te...
Q4UE05        764 KHDAKVSRSDFESLWQRLQpKEFNHNYHHKYTKqRNt--DGGRGIVKALQNYGLYHVGtGLCgdRSsESEFFYTL----T 837  Theileria ann...
Q4UI19        643 VVPETISEEDFQTAWLECE-HSYSTEMELYPNDl------NVEDFEGLFAKLNIMTLAsSD---KDsYSKMYMYT---QD 709  Theileria ann...
Q8IBF8        741 IDVDSINPEVYQTQWNALP-EQNNEKIFLRKNYyNL----QLDTIDQLISKYNLITLA-SGE--IDqCLKFYMYS---QL 809  Plasmodium fa...
XP_020432628  750 ESQTEIQPEDFQENWLNFE-EGHRFDIQLEKLI-------DTNEMEKLLTSKGIMCLAfGSV--AGvTKLYYYAQ---EI 816 
CBN76887      311 SEDEVMMPHAFERLWGAFE-PQGEFQTHITQSV-------PQTTVVRHLNDRGFQVVAaGTV--DGlMRVLFCAKeatSN 380 
XP_002999059  388 SPDANLAASNFWQLWKRTE-TTGAFSCTFANQP-------SRVELEQHLAAHGFRVVAaEQK--DSvLQVYFYAS---QY 454 
XP_001613637  793 IDAENINPEHYQEQWSILP-EQNNEKLFLRKNYyNL----QLETIDEFISKYNIVTLA-SGE--IDqCLKFYMYS---QF 861  malaria paras...
XP_002947067  797 aGQsaALYLVELLLRSDTGN--MQVTVKTA---DTASLPAFLELWNACL 840 
XP_001323783  804 vSQ--DKIIVRITLQPNGs---CMVETLCI---NGEIAKLIAKLIVSIL 844 
A0CBT3       1097 vNG--MPLLVNVIHSPTA----INLQLQVP---HPTLMPLLYQAIGFIL 1136 Paramecium tetraurelia
Q4UE05        838 tNS--LAILAKFTRD--------TFTVKCE---SSTVLMLFAKAVEKML 873  Theileria annulata
Q4UI19        710 eQG--AKYYIEVIIKGGQ----IKVTIKVK---ETNSSESALQSLSEIL 749  Theileria annulata
Q8IBF8        810 yTK--HYIFIELIFNKRDNS--INWIFKSEc-nDENLIEQFTDCFRDIF 853  Plasmodium falciparum 3D7
XP_020432628  817 eNG--PLFLLEILINEKTLLmtLCFKSNNQkrlHNKLVPLFLSTLSKLI 863 
CBN76887      381 gTG--AWFLAELLQDESALT--LEATFKSK---RPAVVPGFVRAFMLHH 422 
XP_002999059  455 gTD--TFFLCEFVLLFARRF--FQATFKCS---EREAASDFVTRFNLQD 496 
XP_001613637  862 yTK--QYIFIELIFNKAENS--INWILKSQs-dDPNMLDRFTDYFRDIF 905  malaria parasite P. vivax
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