1E0F


Conserved Protein Domain Family
Haemadin

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pfam09065: Haemadin 
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Haemadin
Members of this family adopt a secondary structure consisting of five short beta-strands (beta1-beta5), which are arranged in two antiparallel distorted sheets formed by strands beta1-beta4-beta5 and beta2-beta3 facing each other. This beta-sandwich is stabilized by six enclosed cysteines arranged in a [1-2, 3-5, 4-6] disulphide pairing resulting in a disulphide-rich hydrophobic core that is largely inaccessible to bulk solvent. The close proximity of disulfide bonds [3-5] and [4-6] organizes haemadin into four distinct loops. The N-terminal segment of this domain binds to the active site of thrombin, inhibiting it.
Statistics
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PSSM-Id: 72483
View PSSM: pfam09065
Aligned: 3 rows
Threshold Bit Score: 43.1281
Threshold Setting Gi: 74838563
Created: 11-May-2020
Updated: 6-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1E0F_I 19 CDCGEKICLYGQSCNDGQCSGDPKPSS 45 
Q7JPT2  1 CDCGEKICLYGQSCNDGQCSGDPKPSS 27  Indian leech
Q25163 39 CDCGEKICLYGQSCNDGQCSGDPKPSS 65  Indian leech
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