Conserved Protein Domain Family
Smac_DIABLO

?
pfam09057: Smac_DIABLO (This model is not part of the current CDD release)
Second Mitochondria-derived Activator of Caspases
Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.
Statistics
?
PSSM-Id: 518660
Aligned: 9 rows
Threshold Bit Score: 302.907
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q0IJ31         9 IWSFSYILRE-------------SFPIVSrrnc--vslLRASWRKVlsVGVGTSVCAIPVGQRSEP-TLSSESLIKRAVS 72  tropical clawed...
1_pfamImport   1 LRSCCSVLRR-------------SFPVLAgirqrglagRSGQWHQA--VGLGVALCAVPVVEQQSSgSLSNDALIRRAVS 65 
Q5RBH2         9 SRSVTLLFRYrq---------clCVPVVAnfkkrcfseLIRPWHKTvtVGFGVTLCAVPIAQKSEPhSLSSEALMRRAVS 79  Sumatran orangutan
XP_008248773  42 SRSASAWLRRg-----------rCVPAAAggpkrcfseLVRPWRRAaaVGLGVTLCAVPIAQESEPhSLSNDALMKRAVS 110
XP_008118066  16 ARQSRPLLAPl-----------rTRCASG---------LRGPWSKAaaLGLGATLAAIPITQKHDPsSLSNEALIRRAAS 75 
XP_005989033  19 RRRAP-LVAErsshrllgavssvSVPRGT-------------WSRLv-LGFGATLCAVPISQKTESvSLSHGALIKRAVS 83 
XP_003968615  15 RRAACVLLNYrnh--------aiQNPGKW---------ANILYTSLasFTIGAGFCAVPFKQADQ---LSHDSLIKRAAS 74 
3_pfamImport   1 RCSWSVLSSSrhr--------ivRIPLLL-------------RSNFlsLGAGGGLCAVPFSKQAE--NLSHEALIRRASS 57 
XP_415152      8 LRGWCSLLRH-------------GLPALAgtgrrglpgGSGRWRRAvgAGLGAALCAVPVAEKQNSaSLSNDALIKRAVT 74  chicken
Q0IJ31        73 LVADSSSTFLSQTTYALVESLTEYTTAVYTLISLQQKYTSLLDKMNSNEESAIWQVIIGARVQMKQLKEQYLKYESSWQR 152 tropical clawed...
1_pfamImport  66 LVTDSTATLLSQTTYALIEALTEYTKAVYTLVSLYKQYSNLLGKMNSEEVDAVWQVVIGARVDMTSKQQEYLRLESSWMT 145
Q5RBH2        80 LVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSQEEDEVWQVIIGARAEMTSKHQEYLKLETTWMT 159 Sumatran orangutan
XP_008248773 111 LVTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRRYASLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWMT 190
XP_008118066  76 LVTDSTGTLLSQTTYALIDALTEYTTAVYTLVSLYQKYAHLIGKMNSKEEDAVWQVIIGARVEMTEKQQEYLKLESRWMT 155
XP_005989033  84 LVTDSANTYLSQTTLALIDALTEYTKAVHILVSLQQQYANLVGKINPKEEEAIWQVIIGARVEMNEKQQEYLTFESNWVS 163
XP_003968615  75 LVTDSSTTLLSQATLALIDAITDYSKAVHTLIALQKRYLDSLGKLSPAEEDRIWQVIIGQRAEVNDRRDQWLRFESTWGS 154
3_pfamImport  58 LVTDSANTYLSQTTLALVDALAQYAKAVHTLIALQKRYMNSIGKLTPAEEDAIWQVIIGARVEMNDKLDTCRHFESNWMN 137
XP_415152     75 LVTDSTSTLLSQTTYALIEALTEYTKAVYTLVSLYKQYTNLLGKMNSDEVDAVWQVVIGARVDMTTKQQEYLKLESSWMT 154 chicken
Q0IJ31       153 AVSLSEMAAEAAYQSGADQASVTVRNHIQIVQTQVQQARNQAHIAEVQLAASQTDEIkrtITE--DKGNPPSGgsprSSL 230 tropical clawed...
1_pfamImport 146 ALRLSEMAAEAAYQSGADQASVTARSHIQVVKSQVQEVRLLSQKAETKLAEVQTDEL---IKArgEDSSLPQGvlgnADD 222
Q5RBH2       160 AVGLSEMAAEAAYQTGADQAPITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELrqkTQEegEERAESEQ------- 232 Sumatran orangutan
XP_008248773 191 ALSLSEMAAEAAYHTGADQASVTARSHVQLVKSQVQEVRQLSQKAEIKLAEAQTQELrqkTQErgEGRPEPEPe------ 264
XP_008118066 156 ALRLSEMAAEAAYQSGADQASVGTHNHIQLVRTQIQEARQLSQKAESKLAEVQTEELm-kLKEeeALAAARRQ----ASV 230
XP_005989033 164 AVNLSQVAAEAAYQAGADQASVTVHTCVQLAQKQVADMQQLALNAESKLAEVQVEEIr-kTSEreRTASKNTGtrkkTEA 242
XP_003968615 155 AVKLCETAAEAAYASGAEHASISVRTNMQVAQAQVDEARKLSAEAERKLAEAKVMEVe-rMSQrvTS----------MEN 223
3_pfamImport 138 AINLSELAAEAAYNAGADQASVTARTNLNMAQTQVEEMKRLSSEAEKQLAEVKVEEIq-rTAAqaAA----------TRA 206
XP_415152    155 ALRLSEMAAEAAYQSGADQASVTARSHIQLIKSQVQEVRQLSQKAETKLAEAQTEEL---LKTqgEESTLPQG----ILG 227 chicken
Q0IJ31       231 seee-eipEAYLRED 244 tropical clawed frog
1_pfamImport 223 --------DPYLRED 229
Q5RBH2       233 --------EAYLRED 239 Sumatran orangutan
XP_008248773 265 -------qEAYLRED 272
XP_008118066 231 eea----eeAYLRED 241
XP_005989033 243 eeteddipEQYLRED 257
XP_003968615 224 neee-evpDAYLRED 237
3_pfamImport 207 fekeddvpEAYLRED 221
XP_415152    228 std--ageDPYLRED 240 chicken
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap