Conserved Protein Domain Family
Kp4

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pfam09044: Kp4 
Kp4
Members of this fungal family of toxins specifically inhibit voltage-gated calcium channels in mammalian cells. They adopt an alpha/beta-sandwich structure, comprising a five-stranded antiparallel beta-sheet with two antiparallel alpha-helices lying at approximately 45 degrees to these strands.
Statistics
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PSSM-Id: 370259
View PSSM: pfam09044
Aligned: 14 rows
Threshold Bit Score: 110.518
Threshold Setting Gi: 699040911
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006966511   9 VAIAAAQSAVGLGINCHGDTRCGIAYLSGgRLSHLGTVIKKIDD----TRKYENGEDIACIEIDSL--NFKGpfkstLCA 82  Trichoderma ree...
XP_013942640   9 LAAATAQSAAGLGINCEGDSLCGISYLAGgRLTQFQSIFDNIFE----KRIWDNGDDIGCVEMTHL--NFQGsfkgvYCA 82  Trichoderma atr...
CCT72676       8 ASAVLALGASAEGINCHGSSNCANAGF---KLTGLLQTAQGLND----NKWYYNGQHIACWQALDKt---------gFCA 71  Fusarium fujiku...
EMR66332       9 AALSLATGTYSLGINCQGNSNCGGTLC---SLTDILASVKALPQ----NNLYNPGDHIACCGDSAl---ASG-----ICA 73  Eutypa lata UCREL1
CEF71898       6 TLTTLLSAASALGINCRGSGWCNINSA---SLDNVLTKAKQLQArgqgDHHWGEGVQIAC-----SggQWGS-----ICA 72  Fusarium gramin...
CCT64970       9 ALAATAGLSDALGINCRGSGLCSGNKG---ALGQLIAQVRAIDP----NKTFRNGEHVSCVDIN-NigNHPA-----ICA 75  Fusarium fujiku...
EFY91383      10 FAAALMGTSSALGINCRGSGLCASNKG---ILGQAQGQLRGMDQ----NQQFSDGQHITCVKSSVTigN-PS-----LCI 76  Metarhizium acr...
XP_006963527   9 AAASVASVVNALGINCQGSGLCTGNKG---ALGNLLGQVKALDQ----SKTFSDGEQIACVESSVSigN-PS-----LCL 75  Trichoderma ree...
XP_002374615   8 IVASALTANAKLGINCRGSAKCSVLWGPSdAAQQLTNVIQHIDT----NRWYMNGEHIACVGNQAg--NGGG-----YCA 76  Aspergillus fla...
XP_002374614  13 AITLVSSSSAKLGINCRGSANCNTFGNTQ-MAFQLKRAIDGIDP----NRWYNNGEHIACVGSGARitGNGG-----FCA 82  Aspergillus fla...
XP_006966511  83 WIEn--YDDTVSGAAIKA--AFQELLDHGCGICGAVPLLYAKGVDDVNKGELNVDLVD 136 Trichoderma reesei QM6a
XP_013942640  83 YIQn--LDGSVDGATLKS--LYTELIEYGCGICGSIPIHYAKGDNDVNHGELSFNMVD 136 Trichoderma atroviride IMI 206040
CCT72676      72 FLQ---NTGGLPGKDIKK--LLQELVNHGCAKCGSVPAFYPSDNDIKSHGMLTVNYVS 124 Fusarium fujikuroi IMI 58289
EMR66332      74 FVQgdfHDGQISASTAAG--LLQDLVNHGCGKCGSVP--IGPNNDPNADGILTVNWVS 127 Eutypa lata UCREL1
CEF71898      73 FFQ---S--GASGNTDRAveLIQGILDHGCTQCGSIPT---EEGNNVDNGQLTVNYVE 122 Fusarium graminearum
CCT64970      76 FYQ---NIGDRSFSLAQTqtFLQQIVDHGCKLCGSVPT---DPGNNVANGQLTVNVVI 127 Fusarium fujikuroi IMI 58289
EFY91383      77 FYQ---NTNGRRWTVAQTvnFVQQLLDHGCAACGSVPT---DPGNDVKHGELTANMVT 128 Metarhizium acridum CQMa 102
XP_006963527  76 FYQ---KT-GRTFTVAQTvwYVQALIDHGCQACGSIPV---DDGNNVDNGELTANMVa 126 Trichoderma reesei QM6a
XP_002374615  77 FLQ---KTGGTNGGVIKN--LAHYITDHGCKQCGSVPYYFPQGNNNVDDGELTYNYVD 129 Aspergillus flavus NRRL3357
XP_002374614  83 FLQ---NTGGTNGAVIKS--LAHYIPEHGCKVCGSVPYFYPQGNNNVDDGELTFNYVD 135 Aspergillus flavus NRRL3357
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