Conserved Protein Domain Family
Titin_Z
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pfam09042: Titin_Z (This model is not part of the current CDD release)
Titin Z
The titin Z domain, that recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. This interaction is essential for sarcomere assembly.
Links
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Statistics
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PSSM-Id: 518650
Aligned: 22 rows
Threshold Bit Score: 28.0826
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_031748776    501 EEIGGGKKVGAVATVVAAVDLARVRQPGQAEEGYAEDT-LHYEYKE 545  
4_pfamImport      1 EQVEGGKKAEAKATVVAAVDLARVRKPLHAEGGHAEEEtIHSDLKQ 46   
5_pfamImport      1 REVVGGKKAEAKATVVAAVDLARVRKPMHSEGGYAEEEtIDSDLKQ 46   
13_pfamImport     1 NTGKDSEKTAAIATVVAAVDQAMVREPAP---GVAEQTaKRTAMTA 43   
XP_030643510    427 TEQGGVKRAEAVATVLAAVDQARVRKPVHAEEGPAEEEsDSKQQTT 472  
XP_021334745    372 VKEGDGKKAEAVATVLAAVDHARIRKPMHVEGPQMEEEtDVRHQEM 417  
7_pfamImport      1 QEQGVEKKAGAVATVLAAVDQARVRKPVHVESALAEEEmDIKQQSM 46   
1_pfamImport      1 LQDDEGKKAEAVATVMAAVDLARVRQPAHGEAGRADEEeEEQAATE 46   
14_pfamImport     1 REAEGDKKAEAVAAVVAAVDLARVRQSPSQEGVLTQEDqEIKKGKK 46   
XP_013888461     40 LQAEGEKKAEAVATVVAAVDLARVRKPVLEEGDRAEEDeAMDVKEQ 85
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