6BJC,6BJC


Conserved Protein Domain Family
Aurora-A_bind
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pfam09041: Aurora-A_bind (This model is not part of the current CDD release)
Aurora-A binding
The Aurora-A binding domain binds to two distinct sites on the Aurora kinase: the upstream residues bind at the N-terminal lobe, whilst the downstream residues bind in an alpha-helical conformation between the N- and C-terminal lobes. The two Aurora-A binding motifs are connected by a flexible linker that is variable in length and sequence across species. Binding of the domain results strong activation of Aurora-A and protection from deactivating dephosphorylation by phosphatase PP1.
Links
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Statistics
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PSSM-Id: 518649
Aligned: 10 rows
Threshold Bit Score: 121.554
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BJC_T         1 MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ 68  human
XP_002710892   1 MSQVQSSYTFDAPTDFINFTSLNDEEDSENVDLWFEEKANLENKFPGKNGTGELLHGKTTLRKANLQQ 68 
XP_004014519   1 MSQVTTSYSYDAPTDFINFSSLTDEEDTQHIDSWFDEKANLENKFPGKDGTGGLFQGKTPLRKANLHQ 68 
2_pfamImport   1 MSQV-TSYSFDAPTDYINFTSLNDEENNENVDSWFEEKANLENMFPGKNGTGGPFQGKTPLRKGNRQQ 67 
XP_001364540   1 MSQSRASYSFDAPTAFINFTSFNNE-DVCNVDSWFEERANLENKPPEDDEVPGPSYRKTPLRKTHVPQ 67 
XP_012659634   1 MSQVQTSYSYDVPKDFIDFTSLDDEGDTENIDSWFEEKANLENKLLGKNGTGGPFQSKTPLRKSNLQQ 68 
XP_013015444   1 MSQVKNSYSFDAPSNFINFTSLDYDEDTENIDSWFEEKANLENKFFGKNGTGELFQSKTSLKKANLQQ 68 
XP_021578919   1 MSQVTTTYSFDAPTDFINFTSLDDEEDSENIDSWFDEKANLENKYPG-NGTGELFQSKTSVKKGNLQQ 67 
A2APB8         1 MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQ 68  house mouse
6BJC_P         1 MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQ 68  human
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