Conserved Protein Domain Family
TRADD_N

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pfam09034: TRADD_N 
TRADD, N-terminal domain
The N terminal domain of 'tumor necrosis factor receptor type 1 associated death domain protein' (TRADD) folds into an alpha-beta sandwich with a four-stranded beta sheet and six alpha helices, each forming one layer of the structure. The domain allows docking of TRADD onto 'tumor necrosis factor receptor-associated factor' (TRAF): the binding is at the beta-sandwich domain, away from the coiled-coil domain. Binding ensures the recruitment of cIAPs to the signaling complex, which may be important for direct caspase-8 inhibition and the immediate suppression of apoptosis at the apical point of the cascade.
Statistics
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PSSM-Id: 401105
View PSSM: pfam09034
Aligned: 14 rows
Threshold Bit Score: 154.386
Threshold Setting Gi: 123790740
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001372553  90 CS-GSQDGAQILKIHCSGLQLIVQLKFCGQELCGRFLRSYREGALRDALRNSLVPLLDQAQHLgQLHLELHVGSERLDLM 168 gray short-tail...
XP_023187695  51 DSaGGLGGYDILKVHDAEPFLGVEVKFVDVAACQQFLESYSSGAVLQSLNQHACRLLGLPQDF-TVRTQLKAGPQNLDLC 129 southern platyfish
CAF99560      67 DSaRGLRGYEILKVHDADPLLGVEVKFVDVAACQQFLSSYGSGALHQSLSQHACRLLALPQEL-RVETQLKASTHVLDLC 145 spotted green p...
XP_004067240  51 DSaGGLGGYEILKVHDAEPFLGVEVKFVNMAACKQFLDSYSSGALHQSFSQHAGRLFAVAQEC-SVETQLKASTNILDHC 129 Japanese medaka
XP_003442307  51 DSaGGLGTFEILKVHDADPFLGVEVKFMNVAACRQFLESYSSGAVRQYLCQHACRLLALPQEL-TVETQLKAGTHILDRC 129 Nile tilapia
XP_005998087  47 dvvGDSPGYEILKILSSDPQLVVQVKFNEVEKCRQFLRIYKSGTLQQLLQERLRAALLLSE-L-EVQTELKASSSRLDDY 124 coelacanth
XP_004944196 205 DStGSMNGVDVLKVHCSHPHLIVQLKFCKQENCRRFLQSYREGELQKSLQNHLQLSLAMTT-V-PLEMELKAGNEHLDSM 282 chicken
XP_008109942  48 DStGSFHGVDMLKVYCSDPQLIVQLKFSVKENCRRFLQSYREGVLRDALQRHLQVSLALSSRI-PLQTELKAGAEKLDAM 126 green anole
Q3U0V2        51 ESgDSSDVLQILKIHCSDPQLIVQLRFCGRVLCGRFLQAYREGALRTALQRCMAPALAQEA-L-RLQLELRAGAEQLDSW 128 house mouse
XP_013010285  51 ESsQGPDVLQILKIHRSDPQLIMQLRFCGRQSCDRFLRAYREGALRATLQRCLAAALAQPS-M-LLQLELRAGAEQLDAW 128 domestic guinea...
XP_001372553 169 LHEEDRCLRCIHQAKPDRLRDEEISDLEDAFR 200 gray short-tailed opossum
XP_023187695 130 LDQLAVCLQHIHLSQPERLRDEEIDHLEQQLQ 161 southern platyfish
CAF99560     146 LDDLQCCLKHIHLSQPERLCDEEIDHLEQMLQ 177 spotted green pufferfish
XP_004067240 130 LDKLEVCLQHIHQSQPERLRDEEIDQLEQQLQ 161 Japanese medaka
XP_003442307 130 LDKLDLCLQHINLSQPERLRDEEIDELEQQLQ 161 Nile tilapia
XP_005998087 125 LEKEDHCLSCISEEKPDHQKDEDISRLEECLK 156 coelacanth
XP_004944196 283 LKDEDRCLECIYREKPDRLRDEEITELEERLK 314 chicken
XP_008109942 127 IREEERCLECIFGEKPNRLRDEEITELEESLK 158 green anole
Q3U0V2       129 LTDEERCLNYILAQKPDRLRDEELAELEDELC 160 house mouse
XP_013010285 129 LTDEEHCVQTILAQKPDRLRDEELTELEDALS 160 domestic guinea pig
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