Conserved Protein Domain Family
DFF-C
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pfam09033: DFF-C (This model is not part of the current CDD release)
DNA Fragmentation factor 45kDa, C terminal domain
The C terminal domain of DNA Fragmentation factor 45kDa (DFF-C) consists of four alpha-helices, which are folded in a helix-packing arrangement, with alpha-2 and alpha-3 packing against a long C-terminal helix (alpha-4). The main function of this domain is the inhibition of DFF40 by binding to its C-terminal catalytic domain through ionic interactions, thereby inhibiting the fragmentation of DNA in the apoptotic process. In addition to blocking the DNase activity of DFF40, the C-terminal region of DFF45 is also important for the DFF40-specific folding chaperone activity, as demonstrated by the ability of DFF45 to refold DFF40.
Links
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Statistics
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PSSM-Id: 518645
Aligned: 17 rows
Threshold Bit Score: 206.098
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011475250  86 DGGTAWMQRESVMLemDTVD-TGs--SLAPWLDLAQQLKQDLTSIILMSEADLQLLVDAPSTELAAALGFQVKKAEDLQE 162
Q0VC37        99 DGGTAWITQESFDR--DETD-SG---AGLKWKNVARQLKEDLSSIILLSEEELQMLIDVPCSELAQELSQSHVAVQGLQN 172 cattle
XP_005334830  98 DGGTAWISQESVDI--DETD-SG---AGLRWKNVARQLKQDLSSIILLSEEDLQVLINVPCTDLAQELCQSCATVQGLQN 171
O54786       100 DGGTAWVSQESFEA--DEPD-SR---AGVKWKNVARQLKEDLSSIILLSEEDLQALIDIPCAELAQELCQSCATVQGLQS 173 house mouse
XP_015192696  86 DGGTAWL---GVGGeaDEVD-RAv-pGAEGWQEPARRLQQDLSAIVLMSEADLQGLADAPRGALAAALGYEEARTRALQD 160
XP_007246842  85 DGGTAWLRSETVEMetDAVD-SGmdnGVEPWRTVADKLKQNLANIILMSEADLQSLVDVPHKDLGLALGFTPEKTQDLQD 163
XP_040049407  86 DGGTAWMARDSMLVeaDTVD-ASs--AAAPWLDLAQQLKRDLASIILMSDEDLQTLVDAPSIELASAVGFQEKKAQDLQE 162
2_pfamImport   1 DGGTAWMARDSLMMetDAVDfSGg--ADAHWWFLAQQLKQDLTSIILMSEEDLQTLVDVPHQQLASAMDFQEKKAQDLQD 78 
XP_005478278  85 DGGTAWMARDSVLLetDTVD-SSs--TVAPWYELAQQLKQDLTSIILMSEADLQTLVDAPCPELASALGFQEKKAQELQE 161
1_pfamImport   1 DSGTSWLSESV-----DEVD-SA----AEKWKQLARQLKDDLSNIILMSEEDLQVLIDVPCSDLAEELAQSETKVHVLQD 70 

XP_011475250 163 TLQNVLDRREEERQSKELLQLYLRTVEKEDKQLEEASQSSTGtgVAGD--VDVPDG----SEVDS----ASGFMSRTLMV 232
Q0VC37       173 TLQQVLDQREEARQSRQLLELYLRALEKEGGILSKQQESRAD--LGDE--SDAVDTg--iRESFS----EVTPASQILLA 242 cattle
XP_005334830 172 TLQQVLDQREEARQSKQLLELYLQALEKESGILSKQEESKAA--LGED--VDTVDTav-sKEITS----EITLRGQILTV 242
O54786       174 TLQQVLDQREEARQSKQLLELYLQALEKEGNILSNQKESKAA--LSEE--LDAVDTgv-gREMAS----EVLLRSQILTT 244 house mouse
XP_015192696 161 TLQGVLDRRQEERQAKELLQLYLRAAQDE-SRASETAGPRGA--RIEVpgQDVTDGk--eMEVDAagrgASKFSQRTLMV 235
XP_007246842 164 TLQSVLDRREEERQSKELLQLYLKAVEKEGGQALQQTDGKG---------LDEADG----EGAES----DSGFCSGTLLV 226
XP_040049407 163 TLQRVLDRREEERQSKELLQLYLKAAEKEGGQQADQSRPGQEe-AGD---LGV-ET----MEVDS----GSGFVSRTLMV 229
2_pfamImport  79 TLQRVLDRREEERQSKELLQLYLKAVAKE-REQDESSQAAEA--------ADGSDL----TEVDS----ATGFMSRTLMV 141
XP_005478278 162 TLQRVLDRREQERQSKELLQLYLKTVEQENRQQEETSQPSQGg-AGD---VDVPDG----MEVDS----ASGFMSRTLMV 229
1_pfamImport  71 TLQQVLDRREEERQSRQLLELYLEALKTEDSILSKVAEPEAA--PRKE--MDVVDTgtssTDTSA----TTALSGQVLAA 142

XP_011475250 233 LKGKTSPETRLSTEDLQMVV 252
Q0VC37       243 LKEKPAPELSLSSQDLELVA 262 cattle
XP_005334830 243 LKEKPVPELSLSNQDLELVT 262
O54786       245 LKEKPAPELSLSSQDLESVS 264 house mouse
XP_015192696 236 LKGKTSPETRLSNQELQLLI 255
XP_007246842 227 LKGRTSPETRLSNEELQMVV 246
XP_040049407 230 LKGKTSPETRLSTEDLQMVV 249
2_pfamImport 142 LKGKTSPETRLSTEDLQMIV 161
XP_005478278 230 LKGKTSPETRLSTGDLQMVV 249
1_pfamImport 143 LKEKRAPELCLDSQDLELVL 162
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