Conserved Protein Domain Family
Creb_binding

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pfam09030: Creb_binding (This model is not part of the current CDD release)
Creb binding
The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery.
Statistics
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PSSM-Id: 518643
Aligned: 14 rows
Threshold Bit Score: 77.2133
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001352115 2013 QMAMAQQQSQVAQTPQQAQMIQRALMQQQQQqqQQPRqiqaVMPPQqvQPQAPQQQGMQQRGV-----TSNITP------ 2081
3_pfamImport    1 QQQWAGQGMSPQQRQAMMTQMGHSAMMPTQQ--QPPH----QPTPG--HAALMNMAQQQQAAGvpgaaGGNIPQ------ 66  
XP_007502632 2018 QPPWAPGGLSQPQQFQG--GMQRPAMMSGGQ--AGQP----MNMAP--QPGLGQVPAVGQPKQ------GSLPQ------ 2075
Q09472       1992 QPPWSQGGLPQPQQLQS--GMPRPAMMSVAQ--HGQP----LNMAP--QPGLGQV-G-ISPLK-----PGTVSQ------ 2048 human
XP_005161827 1948 AQQTPQG-------PQSTLPIQRPAMPQQVA--QPRM----MVPTQ--GPRP------QAPQR-----AAGIAP------ 1995
XP_011603271 2191 lqpvqqggggqlqpTNQQWGAGGP----QQRpgMMGH----MAPQQ--QAAVNQ------------------PPpqqmnq 2242 torafugu
XP_011602271 2028 gpmVAPQQAQGTPMTQQGQLMQRPMMPQQHGl-QMPG----VIPPQ--Gpsqqgmtpqq--hnmprgipgnIAP------ 2092 torafugu
XP_014340857 2021 MPTMQPGQWQPAPLSQPQSGMARPSIPMTAQ----QP----ASVLR--MPGV------QQPQR-------SISP------ 2071 coelacanth
XP_029706547 1927 AVQNPQGLVPGQTPQQPM-TMQRAMMTPGQQpqQPAR----MLIPQ--QPGARP----QTPQR-----PGTIAP------ 1984 torafugu
XP_029706545 2025 avqnpqGLVPGQTPQQPM-TMQRAMMTPGQQpqQPAR----MLIPQ--QPGARP----QTPQR-----PGTIAP------ 2082 torafugu
NP_001352115 2082 --------------------------------------GALQDLLRTLKSPSSPQQQQQVLNILKSNPHLMAAFIKQRTA 2123
3_pfamImport   67 --------------------------------------GALQELLRTLRSPSSPLQQQQVLNILRSNPQLMAAFIKQRAA 108 
XP_007502632 2076 --------------------------------------AALQNLLRTLRSPSSPMQQQQVLNILHANPQLLAAFIKQRAA 2117
Q09472       2049 --------------------------------------QALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAA 2090 human
XP_005161827 1996 --------------------------------------NALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTA 2037
XP_011603271 2243 qqpqpgnrgmmpglgvsggavglpasiagaaasgnlpqGALQELLRTLRSPSSPLQQQQVLNILRSNPALMAAFIRQRAA 2322 torafugu
XP_011602271 2093 --------------------------------------SALQELLRTLKSPNSPQQQHQVLTILKSNPHLMAAFIKQRTA 2134 torafugu
XP_014340857 2072 --------------------------------------NALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTA 2113 coelacanth
XP_029706547 1985 --------------------------------------NALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTA 2026 torafugu
XP_029706545 2083 --------------------------------------NALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTA 2124 torafugu
NP_001352115 2124 KYQANQPQ 2131
3_pfamImport  109 KYKGGQGG 116 
XP_007502632 2118 KYVTQNPQ 2125
Q09472       2091 KYANSNPQ 2098 human
XP_005161827 2038 KYHASQPQ 2045
XP_011603271 2323 RYQggqgg 2330 torafugu
XP_011602271 2135 KYqanqqq 2142 torafugu
XP_014340857 2114 KYQASQPG 2121 coelacanth
XP_029706547 2027 KYQANQPQ 2034 torafugu
XP_029706545 2125 KYQANqpq 2132 torafugu
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