Conserved Protein Domain Family
Preseq_ALAS

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pfam09029: Preseq_ALAS 
5-aminolevulinate synthase presequence
The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.
Statistics
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PSSM-Id: 401101
View PSSM: pfam09029
Aligned: 12 rows
Threshold Bit Score: 149.171
Threshold Setting Gi: 47209589
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005327047   2 ETVVRRCPFLSRVPQAFLQKAGK-SLLFYAQNCPKMMevgs----kpvPRAVSTSAVHCQQI-K--ETPPASEKDKtaka 73  thirteen-lined ...
XP_027859352   2 EVIVRRCPFLACVPQAFFQQSRK-SMVTYAQRCPIMMelaskpmapsmARALCSSTSNQTTEiKtgNVPVVGVESK---- 76  Monterrey platy...
XP_022538346   1 mdaIIRCPFLSRVPQAFLQQARK-SLVSYAVKCPVMMdlas----rplVRAVCSSSTSFQKS-Q--DTVSSTEEPKea-- 70  Mexican tetra
NP_958444      1 mdaiIRCPFLSRVPQTFLQQARK-SLVAYAVKCPVMMdlas----rplLRPLCSSSASFQKV-E--DSSSAGHEASda-- 70  zebrafish
XP_005997366   2 ASFLHHCPFLSLLPRACLHRARS-SLIHYAVCCPVMM-----------TRGLSTTSADLHGMkD--VTPVAAPTS----- 62  coelacanth
CAF94336       2 AAFLHHCPFLKSGPNPALRRSGT-ALLSMAHLCPII------------ARQISVSSIAAPGEdL--AISPAKPTADq--- 63  spotted green p...
Q6DF22         2 ASLINRCPFATRDPTVFLRVARP-FLLRSAERCPVMV-----------TCTLSTSPGCEQRTkD--TTPVTGVSTGas-- 65  tropical clawed...
XP_008120949   2 ASLLHRCPFFTRDPATVLHKLRP-LLVCSAQRCPVFM-----------THSFSQSVANLQHGkE-----TPGDTASv--- 61  green anole
1_pfamImport   1 DAVIRRCPFLTAVPGVVLQLAGKfSLVSYAQKCPVMM-----------GRALSSSASASKGApTndDVSLSSAGPKhe-- 67 
XP_002194991   2 EAVVRRCPFLARVSQAFLQKAGP-SLLLYAQHCPRMMeaa-----ppaARALATSAARGQQA-E--EESPAGREAKnvke 72  zebra finch
XP_003210052   2 EAVVRRCPFLARVSQAFLQKAGP-SLLLYAQHCPKMMeavp----paaARGLATTAVREQQA-E--ETPAARPEAKnake 73  turkey
XP_022353447   2 ETVVRRCPFLSRVPQAFLQKAGK-SLLFYAQNCPKMMefga----kpaTRALSTSAVHGQQV-K--ETPPANEKDKtaka 73  Enhydra lutris ...
XP_005327047  74 kvqqapdrsqqtpngtqLPPGHHSP--------AMSQGTASKCPFLAAQMSQTGSNVFCKASLELQEDVQEMH 138 thirteen-lined ground ...
XP_027859352  77 -----------------LPTGHPVP--------TTGQAVASKCPFLAAEMKQKNSGVVRQVTMEFQEDVEEVR 124 Monterrey platyfish
XP_022538346  71 ---------------pkMPSAHPTV--------PAGQTSASKCPFLAAEMG-PNSSVVRQASLELQEDVSEVR 119 Mexican tetra
NP_958444     71 ---------------paVPAGHPAP--------PAGHASASKCPFLAAEMSQKNSGVVRQASMALQEDVSEVR 120 zebrafish
XP_005997366  63 -----------------LKIAHQVPlnsrsvvqTASQPVVSKCPFAQPEIANGASKVVRKASPEVQEDVQDgs 118 coelacanth
CAF94336      64 ----------------rRPLTQTSP--------QVDVSVAKGCPFVTSRIG------MVHASPEVQEDIKKGL 106 spotted green pufferfish
Q6DF22        66 ---------------nrRTLAQAAP--------QAAISNAT-CPFIENEIGKSEGIIVQRAGPQVQEDISAFK 114 tropical clawed frog
XP_008120949  62 ----------------lQPVPASLP--------------TTQCPFIESERQSGRSPFVQVAKPEVQEDVWpsk 104 green anole
1_pfamImport  68 ---------------vkLPPGHTTS--------PAGQAAGSKCPFLAAEMVQKNNRVVREASMELQEDVQEMH 117
XP_002194991  73 vaq-------qnadgaqLPAGHPPA--------SASQSTATKCPFLAAQMNHKKSNVFCKASLELQEDVQEVQ 130 zebra finch
XP_003210052  74 vaq-------qntdgsqPPADHPPA--------AAGQSSATKCPFLAAQMNHKSSNVFCKASLELQEDVKEMQ 131 turkey
XP_022353447  74 evqqaadgsqqtphgtqFPSGHPSL--------ATSQGTASKCPFLAAQMSQKGSSVFCKASLELQEDVQEMH 138 Enhydra lutris kenyoni
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