Conserved Protein Domain Family
Preseq_ALAS

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pfam09029: Preseq_ALAS 
5-aminolevulinate synthase presequence
The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.
Statistics
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PSSM-Id: 490075
Aligned: 9 rows
Threshold Bit Score: 129.918
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005327047   2 ETVVRRCPFLSRVPQAFLQKAGK-SLLFYAQNCPKMMevgs----kpvPRAVSTSAVHCQQI-K--ETPPASEKDKtaka 73 
XP_005797027   2 EVIVRRCPFLACVPQAFFQQSRK-SMVTYAQRCPIMMelaskpmapsmARALCSSTSNQTTEiKtgNVPVVGVESK---- 76 
2_pfamImport   1 DAVIRRCPFLTAVPGVVLQLAGKfSLVSYAQKCPVMM-----------GRALSSSASASKGApTndDVSLSSAGPKhe-- 67 
4_pfamImport   1 MDAIIRCPFLSRVPQAFLQQARK-SLVSYAVKCPVMMdlas----rplVRAVCSSSTSFQKS-Q--DTVSSTEEPKea-- 70 
1_pfamImport   1 ASLLHRCPFFTRDPATVLHKLRP-LLVCSAQRCPVFM-----------THSFSQSVANLQHGkE-----TPGDTASv--- 60 
3_pfamImport   1 AAFLHHCPFLKSGPNPALRRSGT-ALLSMAHLCPII------------ARQISVSSIAAPGEdL--AISPAKPTADq--- 62 
XP_005997366   2 ASFLHHCPFLSLLPRACLHRARS-SLIHYAVCCPVMM-----------TRGLSTTSADLHGMkD--VTPVAAPTS----- 62 
XP_002194991   2 EAVVRRCPFLARVSQAFLQKAGP-SLLLYAQHCPRMMeaa-----ppaARALATSAARGQQA-E--EESPAGREAKnvke 72 
XP_003210052   2 EAVVRRCPFLARVSQAFLQKAGP-SLLLYAQHCPKMMeavp----paaARGLATTAVREQQA-E--ETPAARPEAKnake 73 
XP_005327047  74 kvqqapdrsqqtpngtqLPPGHHSP--------AMSQGTASKCPFLAAQMSQTGSNVFCKASLELQEDVQEMH 138
XP_005797027  77 -----------------LPTGHPVP--------TTGQAVASKCPFLAAEMKQKNSGVVRQVTMEFQEDVEEVR 124
2_pfamImport  68 ---------------vkLPPGHTTS--------PAGQAAGSKCPFLAAEMVQKNNRVVREASMELQEDVQEMH 117
4_pfamImport  71 ---------------pkMPSAHPTV--------PAGQTSASKCPFLAAEMG-PNSSVVRQASLELQEDVSEVR 119
1_pfamImport  61 ----------------lQPVPASLP--------------TTQCPFIESERQSGRSPFVQVAKPEVQEDVWPSK 103
3_pfamImport  63 ----------------rRPLTQTSP--------QVDVSVAKGCPFVTSRIG------MVHASPEVQEDIKKGK 105
XP_005997366  63 -----------------LKIAHQVPlnsrsvvqTASQPVVSKCPFAQPEIANGASKVVRKASPEVQEDVQDGS 118
XP_002194991  73 vaq-------qnadgaqLPAGHPPA--------SASQSTATKCPFLAAQMNHKKSNVFCKASLELQEDVQEVQ 130
XP_003210052  74 vaq-------qntdgsqPPADHPPA--------AAGQSSATKCPFLAAQMNHKSSNVFCKASLELQEDVKEMQ 131
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