Conserved Protein Domain Family
Mac-1
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pfam09028: Mac-1 
Mac 1
The bacterial protein Mac 1 adopts an alpha/beta fold, with 14 beta strands and 9 alpha helices. The N-terminal domain is made up predominantly of alpha helices, whereas the C-terminal domain consists predominantly of beta sheets. Mac 1 blocks polymorphonuclear opsonophagocytosis, inhibits the production of reactive oxygen species and contains IgG endopeptidase activity.
Links
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Statistics
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PSSM-Id: 490074
Aligned: 2 rows
Threshold Bit Score: 611.671
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012775646   72 EIADNIPSPVIAEGEvavEMKVDRGTENVVSRNDTEVTTSEQNQIEVTETKEILNQTSYQTESGEQRQIIWAHGITPPAM 151  Streptococcus...
EGG92260      470 EENNNTVQPPVSGNT---ENPTQPDTQEQPNKNEESAEDKAQRIKDYLITPENDNVVQYTNEDGEIRTIIWAKGINGPVM 546 

WP_012775646  152 EQSGGFVKE----KYGDYLNYTAPFEAGKGYYDTNKSLNASFIDL--NLCFAAVSSNMVHWWLEQNSSYVERYLKEKKGT 225  Streptococcus...
EGG92260      547 GEGGDFHKEitqgGSDTYVSYKAPFSSGDGWYDVNKTRSGGNIDIdkNLCFAAVASNMLHWWFDQNIENVDNYIVKNGDI 626 

WP_012775646  226 VNVEENYA-ITdlrryiNSFQNQQNSRVFDMFKTYYGYRTNGFVSDALVDLFINGYKPKAQGGVNLEDSQLVPDSRGGFF 304  Streptococcus...
EGG92260      627 THANRQLSdLK------ASFESQEESKIFELYKVLYGYNERGFYTDLLVDLFINGYTPKLSGATNIERDDLVPDNNGGFF 700 

WP_012775646  305 YDVFKEKKLTNRIFSGSYERFGEDVRTVLESKGLLGLTYRTLGYATHIVTVWGAEYDNQGKIKAVYITDSDDQ-QEQIGL 383  Streptococcus...
EGG92260      701 YDVFKEKKLTDRTYGGRYESLSEDLKLELGRGGLVGLSHKVFSRNNHIVTLWGAEYDLNGKLKAVYVSDSDDQdESNVGM 780 

WP_012775646  384 KRMGItRDASGNPRLNNHMKNNSAGALLDYVHTIRLGQDLW 424  Streptococcus suis
EGG92260      781 KRYEV-RNVGGIAKVSTNITDKSAGAAVGYLHILYLGTNQW 820
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