2CTO


Conserved Protein Domain Family
HMG_box_2

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pfam09011: HMG_box_2 (490064 is an unknown moldel)
HMG-box domain
This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.
Statistics
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PSSM-Id: 490064
Aligned: 7 rows
Threshold Bit Score: 89.8212
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CTO_A         9 PNR-KASRNAYYFFVQEKIPELRRRg-----LP--VARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPSE 80  human
1_pfamImport   1 PKKpKGKMSAYAFFVQTCREEHKKK------NPevPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDYG 74 
XP_002115932  36 PKKpKRARNSYLMYMTDRWNQAKES------GQ--VPEIREFTEESSSNWRNMSEEEKEEYHQRAQIDRNRFSREMMTYN 107
Q66IB6         6 VNKpKGKTSAYAFFVQTCRDEHKRK------SPdvPVNFSEFSKKCSERWKSLNASDKVKFEDMAKADKVRYDREMKTYV 79  zebrafish
XP_001325470  26 PPKpKRPPNAYNLYYLEMQPKMKAE------NP--LIGGNDVSKLIGQQWGALSDEQKKPYIEKANEIREQFRRENPNWH 97 
Q08D62         2 PNK-KAARNAYFFFALDMIPELRRRg-----LQ--VSGVREAIPLCSEDWALLSADQKEAYAEKARLLKNDPDSTSTYND 73  tropical clawed...
XP_018634851  64 AKRsRAAPSAYFLFAKKEQATIRQQlanesgRE--RIPLGEVQKALSEKWRNISSAEREAYYEEAREKKQEYQQEALWHD 141
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