2CTO,2EQZ


Conserved Protein Domain Family
HMG_box_2

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pfam09011: HMG_box_2 
Click on image for an interactive view with Cn3D
HMG-box domain
This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.
Statistics
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PSSM-Id: 401091
View PSSM: pfam09011
Aligned: 9 rows
Threshold Bit Score: 86.3024
Threshold Setting Gi: 159163948
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CTO_A         9 PNR-KASRNAYYFFVQEKIPELRRRg-----LP--VARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPS 79  human
EDV21784      36 PKKpKRARNSYLMYMTDRWNQAKES------GQ--VPEIREFTEESSSNWRNMSEEEKEEYHQRAQIDRNRFSREMMTY 106 Trichoplax adhae...
Q66IB6         6 vNKpKGKTSAYAFFVQTCRDEHKRK------SPdvPVNFSEFSKKCSERWKSLNASDKVKFEDMAKADKVRYDREMKTY 78  zebrafish
EAY13247      26 PPKpKRPPNAYNLYYLEMQPKMKAE------NP--LIGGNDVSKLIGQQWGALSDEQKKPYIEKANEIREQFRRENPNW 96  Trichomonas vagi...
XP_002597116   6 KNKpQR--NGFWVYMQEMIPEYKRQg-----YQm-PNGMADVVKLAHPSWKAMPEMEKQEYERQAKELKKSASATAGRL 76  Florida lancelet
Q08D62         2 PNK-KAARNAYFFFALDMIPELRRRg-----LQ--VSGVREAIPLCSEDWALLSADQKEAYAEKARLLKNDPDSTSTYN 72  tropical clawed ...
ESS34112      64 AKRsRAAPSAYFLFAKKEQATIRQQlanesgRE--RIPLGEVQKALSEKWRNISSAEREAYYEEAREKKQEYQQEALWH 140 Toxoplasma gondi...
AFR33808       6 PGKpKGKMSAYAYFVKTCREEHNKK------NPgvTVNFSEFSKKCSERWKTMSPKEKTKFEDLAKQDKARYDQEMMHY 78  grass carp
2EQZ_A        13 PKKpKGKMSAYAFFVQTCREEHKKK------NPevPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDY 85  human
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