2CTO,2EQZ


Conserved Protein Domain Family
HMG_box_2
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pfam09011: HMG_box_2 (This model is not part of the current CDD release)
HMG-box domain
This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.
Links
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Statistics
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PSSM-Id: 518635
Aligned: 8 rows
Threshold Bit Score: 89.0491
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2CTO_A         9 PNR-KASRNAYYFFVQEKIPELRRR------GlP--VARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPS 79  human
XP_002115932  36 PKKpKRARNSYLMYMTDRWNQAKES------G-Q--VPEIREFTEESSSNWRNMSEEEKEEYHQRAQIDRNRFSREMMTY 106
Q66IB6         6 VNKpKGKTSAYAFFVQTCRDEHKRK------S-PdvPVNFSEFSKKCSERWKSLNASDKVKFEDMAKADKVRYDREMKTY 78  zebrafish
XP_001325470  26 PPKpKRPPNAYNLYYLEMQPKMKAE------N-P--LIGGNDVSKLIGQQWGALSDEQKKPYIEKANEIREQFRRENPNW 96 
Q08D62         2 PNK-KAARNAYFFFALDMIPELRRRg-----L-Q--VSGVREAIPLCSEDWALLSADQKEAYAEKARLLKNDPDSTSTYN 72  tropical clawed...
Q96JY0         2 PNR-KASRNAYYFFVQEKIPELRRRg-----L-P--VARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPS 72  human
XP_018634851  64 AKRsRAAPSAYFLFAKKEQATIRQQlanesgR-E--RIPLGEVQKALSEKWRNISSAEREAYYEEAREKKQEYQQEALWH 140
2EQZ_A        13 PKKpKGKMSAYAFFVQTCREEHKKK------N-PevPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDY 85  human

2CTO_A        80 E 80  human
XP_002115932 107 N 107
Q66IB6        79 V 79  zebrafish
XP_001325470  97 H 97 
Q08D62        73 D 73  tropical clawed frog
Q96JY0        73 E 73  human
XP_018634851 141 D 141
2EQZ_A        86 G 86  human
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