Conserved Protein Domain Family
Exotox-A_cataly

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pfam09009: Exotox-A_cataly (This model is not part of the current CDD release)
Exotoxin A catalytic
Members of this family, which are found in prokaryotic exotoxin A, catalyze the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis.
Statistics
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PSSM-Id: 518633
Aligned: 2 rows
Threshold Bit Score: 320.442
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P11439   447 LLQAHRQLEERGYVFVGYHGTFLEAAQSIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDArgrirNGALLRV 526 Pseudomonas aerugin...
KMN83734 440 LQATHQRLLDQGYVFAGYHGGSLAAATSIVTGGITRRSQELQPIWRGLYIAGNPEVAYGYALDNDSGA-----TGIMMRV 514
P11439   527 YVPRSSLPGFYRTGLTLAAPEAA-GEVERLIGHPLPLR----LDAITGPEEEGGRLETILGWPLAERTVVIPSAIPTDpr 601 Pseudomonas aerugin...
KMN83734 515 YVPRAALSRLFRTSQPLNDEAAAlREISRLLGRNVTLNsvlgYESITGPQDPGEPDETILGWDLAEHAVAIPSMIQGN-- 592
P11439   602 nvgGDLDPSSIPDKEQA 618 Pseudomonas aeruginosa PAO1
KMN83734 593 ---NSVRPINVPDYEKK 606
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