1IKQ


Conserved Protein Domain Family
Exotox-A_cataly

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pfam09009: Exotox-A_cataly 
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Exotoxin A catalytic
Members of this family, which are found in prokaryotic exotoxin A, catalyze the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis.
Statistics
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PSSM-Id: 401089
View PSSM: pfam09009
Aligned: 4 rows
Threshold Bit Score: 243.233
Threshold Setting Gi: 528051521
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1IKQ_A   422 LLQAHRQLEERGYVFVGYHGTFLEAAQSIVFGGVRARSQDldaIWRGFYIAGDPALAYGYAQDQEPDArgriRNGALLRV 501 Pseudomonas aeruginosa
EPX56367   1 MRDADKRLRDNGYVFVGFKGAPKHKAMDAVNNGLHARMGK---DWSGLYVADNPQVAAGYTADDETGSa---KGGQLVRV 74  Cystobacter fuscus ...
EPX57630  53 LADAHNELTRRGYAFVGFKGSSEQGAMNAVNGGLRAQGGD---KWSGIYVSDQTAVAAGYTADEMGRS----KGGQLVRV 125 Cystobacter fuscus ...
KMN83734 440 LQATHQRLLDQGYVFAGYHGGSLAAATSIVTGGITRRSQElqpIWRGLYIAGNPEVAYGYALDNDSGA-----TGIMMRV 514 Chromobacterium sp....
1IKQ_A   502 YVPRSSLPGFYRTSLTLAAPEAA-GEVERLIGHPLPLRl----dAITGPE--EEGGRLETILGWPLAERTVVIPSAIPTD 574 Pseudomonas aeruginosa
EPX56367  75 YVPRQDAKNLVNMETPLSKESTAkKEFKDTFGFRIGEDrs---yAIRGYEr-EDRESTETILSGKVAARAVAIPSTIKVD 150 Cystobacter fuscus ...
EPX57630 126 YVPQQDAEKLQNLATPMDNPRVE-NEFRKNMGFRLGDDrs---yIIRGQEttDDKYRTETVLSPKVAERAVAIPSTVLVD 201 Cystobacter fuscus ...
KMN83734 515 YVPRAALSRLFRTSQPLNDEAAAlREISRLLGRNVTLNsvlgyeSITGPQ--DPGEPDETILGWDLAEHAVAIPSMIQGN 592 Chromobacterium sp....
1IKQ_A   575 PRNVgGDldpssIPDK----EQA 593 Pseudomonas aeruginosa
EPX56367 151 QRFG-GD-----ITDYpgaeERR 167 Cystobacter fuscus DSM 2262
EPX57630 202 QKFGsGE-----VQDFsa-fERQ 218 Cystobacter fuscus DSM 2262
KMN83734 593 -----NSvrpinVPDY----EKK 606 Chromobacterium sp. LK11
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