3FLO,8G99,8D0K


Conserved Protein Domain Family
zf-DNA_Pol
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pfam08996: zf-DNA_Pol (This model is not part of the current CDD release)
DNA Polymerase alpha zinc finger
The DNA Polymerase alpha zinc finger domain adopts an alpha-helix-like structure, followed by three turns, all of which involve proline. The resulting motif is a helix-turn-helix motif, in contrast to other zinc finger domains, which show anti-parallel sheet and helix conformation. Zinc binding occurs due to the presence of four cysteine residues positioned to bind the metal centre in a tetrahedral coordination geometry. Function of this domain is uncertain: it has been proposed that the zinc finger motif may be an essential part of the DNA binding domain.
Links
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Statistics
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PSSM-Id: 518624
Aligned: 122 rows
Threshold Bit Score: 133.886
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3FLO_B           7 TTITDVERFKDTVTLELSCPS--CDKRFPFGGIV-SSNYYRVSYNGLQCK--HCEQLF--TPL--QL--TSQIEHSIRAH 75   brewer's yeast
XP_015196960  1290 AQLTDEEKYRDCERFKFACPR--CRTENVYDAVFeGA-GEHLQPSLMRCCgdQCEASP--ISF--RAeiSNKLVLDIRRH 1362
12_pfamImport    1 VQLTDEERYRDCERFTFTCPS--CGTDNIYDNVFeGA-GNKVEPGLMRCChiPCQSRPidHPV--HI--SNKLLLDIRRH 73  
XP_005809925  1283 AQLNDEERYKDCERFTFTCPQ--CGTDNIYDSVFeGA-GDRAEPSLMRCChiPCTNSP--INN--VVniSNKLQLDIRRH 1355
1_pfamImport     1 VQLTDEERYKDCERFTFTCPQ--CGTDNIYDGVFeGA-GAKVEPSLMRCChiPCGGSP--ADY--IVniSNKLVLDIRRH 73  
9_pfamImport     1 VQLTDEERYKDCERFTFACPQ--CGTDNVYDGVFeGA-GSKLEPSLMRCChlPCRGQP--VDY--GVniSNKLLQDVRRH 73  
XP_046447613  1216 PPVTDEERFQSCEKFYYQCSDkaCGFEMSMDNVFrKTDDGNIEFALSRCGnpNCKKTP--FSA--EKflVNRLTHTVRKH 1291
XP_002425588  1253 IFGNDLEAFKRCEVFSFVCKGenCGTVNYIDSPMrDN-----VPSLSKCRnpSCNTSP--ITY--LTniVNELTIKIKTH 1323
EDS42058      1255 VQKTIAQKYRMCHRFEFKCVA--CGSNNPVAAGFrKD-GGKQKSVFERCAneKCDVRP--LHY--LPaiKNQLTLAIRGD 1327
8D0K_F        1329 aQLTDEEKYRDCERFKCPCPT--CGTENIYDNVFdGS-GTDMEPSLYRCSniDCKASP--LTFtvQL--SNKLIMDIRRF 1401 human

3FLO_B          76 ISLYYAGWLQCDDSTCGIVTRQVSVFGKR----C--LNDGC-TGVMRYKYSDKQLYNQLLYFDSLFDCEKN--------- 139  brewer's yeast
XP_015196960  1363 IRKYYSGWLVCEEQACQNRTQRLPLAFSRsgpmC--PA--CmKATLRPEYSEKALYNQLCFYRYIFDWDYA--------- 1429
12_pfamImport   74 IKKYYSGWLVCEDQACQNRTRRLPIAFSRhgpiC--PA--CsRATLRPEYSEKALYNQLCFYRFIFDWEHA--------- 140 
XP_005809925  1356 IKKYYSGWLVCEDQACQNRTRRLPIAFSRhgpiC--PA--CtRATLRAEYSEKALYNQLCFFSYIFDWDYA--------- 1422
1_pfamImport    74 IKRYYAGWLMCEDQACQNRTRRLPIAFSRhgpiC--PA--CsRATLRPEYSEKALYNQLCFYRFIFDWEYA--------- 140 
9_pfamImport    74 VRKYYSGWLVCEDPACQNRTRRLPVGFSRhgpiC--PA--CtRATLRPEYSEKALYYQLCFYRFIFDWDQA--------- 140 
XP_046447613  1292 IQLYYAGWLVCEDRSCATRTRRIPLKSTNthpvC--IG--CgTSNMDPEYNDLDLYTQLCYYQHMFDASKA--------- 1358
XP_002425588  1324 IRKFYQNWLICEDPACTNRTQRVPMKFSNtfpvCn-L---CnKGAMYREYTSSDLYYQIKYYKHVFTLEKVkffaffnkk 1399
EDS42058      1328 IKRFYERWMVCDNPICSVNTRLSSQVATKnnpnC--LH--ClKGLLVQQYSETDLYLQLNYYNYIFDLSHY--------- 1394
8D0K_F        1402 IKKYYDGWLICEEPTCRNRTRHLPLQFSR----TgpLCPACmKATLQPEYSDKSLYTQLCFYRYIFDAECA--------- 1468 human

3FLO_B         140 -------------KKQELKPiylpddldypkeQ-----LTESSIKALTE-QNRELMETGRSVVQKYLNDCGRRYVDMTSI 200  brewer's yeast
XP_015196960  1430 -------------YAKCLQS------------EeratvKQNRWSNL------RDVYVKLRDVVEQTLATSGYSEVNLSKL 1478
12_pfamImport  141 -------------FSKVLTQ------------E----------ERRKPK-FSYTKLKPLLSFVKKALAASGYSEVNLAKL 184 
XP_005809925  1423 -------------MAKLPNT------------VqktclKRSGSTRQ--------VYLKLKEVPDRALATSGYSEVNLAKL 1469
1_pfamImport   141 -------------VTKVLNP------------E-------ERSKIIHTQ-GQHYVYRKLKEVPDKALASSGYSEINLAKL 187 
9_pfamImport   141 -------------VAKLTSD------------E------KSKITNTHTH-VCCDVYRRLKEVPDKALAASGYSEINLAKL 188 
XP_046447613  1359 -------------ISQLQPS------------E------RDKVKLAYNN-SMDKAYKALLNNINQILLESGYSQVNLAGL 1406
XP_002425588  1400 rfnfiilllfsffLQKNYEL------------P---------------E-DVREGYKILQEKVLKVLNMSAYNSLDLGKM 1451
EDS42058      1395 ---------------------------------------SSKFTRTLPL-DIREAHDKLREMVRQFLVQSKYATVRMSTL 1434
8D0K_F        1469 -------------LEKLTTD------------H-----EKDKLKKQFFTpKVLQDYRKLKNTAEQFLSRSGYSEVNLSKL 1518 human

3FLO_B         201 F 201  brewer's yeast
XP_015196960  1479 F 1479
12_pfamImport  185 F 185 
XP_005809925  1470 F 1470
1_pfamImport   188 F 188 
9_pfamImport   189 F 189 
XP_046447613  1407 F 1407
XP_002425588  1452 F 1452
EDS42058      1435 Y 1435
8D0K_F        1519 F 1519 human
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