Conserved Protein Domain Family
NRBF2
?
pfam08961: NRBF2 (This model is not part of the current CDD release)
Nuclear receptor-binding factor 2, autophagy regulator
NRBF2 plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction.
Links
?
Statistics
?
PSSM-Id: 518601
Aligned: 5 rows
Threshold Bit Score: 281.812
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_008112965  95 AMDRDGVTHPQASSKPSAEESDDQSVAAPASLKYSPSPEKDLQAKLSVLDRDPDTLLFLLQKRKEPQEACVRSKTPKDDK 174
NP_001016183  92 VAERELSAHLQASYRSAADNADSQNTLGSAGQKSGSNPGKYVQDIPSVLDREPDSLMYLLQRRKEPMETCKVSKAPKDDK 171
XP_028916708  89 TTDREAAGPLQASPKAPADDAEGPA--GPRIPRRSPSMERRLPEIQGIFDRDPDTLLFLLQKRKEPTETCIGSRAPKDDK 166
Q96F24        89 NTDKDAAAHLQTSHKPSAEDAEGQS---PLSQKYSPSTEKCLPEIQGIFDRDPDTLLYLLQQKSEPAEPCIGSKAPKDDK 165 human
XP_005997768  86 STDLDMTTHLQSLPKVFAEEADGKKVLRSSNERYSPVKEQYLRKMQYVFDRDPDTLLFLLENREVQTEACQGSKAPKDDK 165 coelacanth

XP_008112965 175 TKMEEQATKIALLERHVEVLLAENERLRQENKQLKAERARLLKSPlEKELDVDADFVEKSELWGLQQHSETaAATSASSW 254
NP_001016183 172 TKLEEQATTIKELNQLVDTLLAENEALRKENKKLRAEVARLQKNP-EKDLDIDTDFVEKSELWNLQQPTGS-AANPTSAW 249
XP_028916708 167 TIIEEQATQIEDLKRHVEFLVAENDRLRRENRQLKADKARLQKAPrDKELEGDADFVEKSELWGLQPQSEM--ATASSTW 244
Q96F24       166 TIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGPiEKELDVDADFVETSELWSLPPHAET--ATASSTW 243 human
XP_005997768 166 TRIEEQETKIAELKRLVELLLAENERLMKENHRLKGENARLQKVPiEKELDVDADFVEKSELWALPQSSKS-PTSTAPTW 244 coelacanth

XP_008112965 255 QKF-TSSAGKAKDIPIPSLPPLDIPSPELPLLELSEDILKGL 295
NP_001016183 250 QKF-VAHSGKGTDIPIPNLPPLDIPLPELPPLELPEDIQSQL 290
XP_028916708 245 QKFaAANTGKAKDIPIPNLPPLDFPSPELPLLELSEDILKGL 286
Q96F24       244 QKF-AANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGF 284 human
XP_005997768 245 QNL-TGEAGKAKDIVVLNLPPLDIPLPDLPPLELPEDIQCDL 285 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap