2K19


Conserved Protein Domain Family
EntA_Immun

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pfam08951: EntA_Immun (This model is not part of the current CDD release)
Enterocin A Immunity
Gram-positive lactobacilli produce bacteriocins to kill closely-related competitor species. To protect themselves from the bacteriocidal activity of this molecule they co-express an immunity protein (for discussion of this operon see Bacteriocin_IIc pfam10439). The immunity protein structure is a soluble, cytoplasmic, antiparallel four alpha-helical globular bundle with a fifth, more flexible and more divergent C-terminal helical hair-pin. The C-terminal hair-pin recognises the C-terminus of the producer bacteriocin and this interaction is sufficient to dis-orient the bacteriocin within the membrane and close up the permeabilising pore that on its own the bacteriocin creates. These immunity proteins interact in the same way with other bacteriocins, family Bacteriocin_II, pfam01721. Since many enterococci can produce more than one bacteriocin it seems likely that the whole operon can be carried on transferable plasmids.
Statistics
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PSSM-Id: 518594
Aligned: 39 rows
Threshold Bit Score: 31.1163
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2K19_A        19 NIITDLldDLKtDLDNES--LKKVLENYLEE-LKQKSASVp-lILSRMNLDISKAIRNDGVTLSDYQSKKLKE 87  unidentified
Q8CYC3        14 KDLYNH------ARHDLSedLVAALLETAKKlPTTNEQLQ----AVRLSGLVNRELLLNPKHPAPELLNLARF 76  Streptococcus pneumoni...
WP_003642489  10 TLVDAAynQPI-TNQPSDs-YRQALLAAAIDlNNNVSPQQ---VTIQLYQAYYRNYMV-PMTLPRQHRDLYQY 76  Lactiplantibacillus
WP_015911746  10 KQIQIAydYPE-NRENRQ--LSSYLLSASNQlIKNQNPII---IARELNTQIDNYLLQDDSRLSQSLWNLKta 76  Streptococcus uberis
WP_022746269  28 NELQKTldDPK-VKSNQE--LTDILTSYKDKlENGGEYKF---VCTKLTGDIAAYVRHNHFKAPESVLKLYND 94  Clostridium saccharobu...
Q8CYQ8         8 ERVEQLlqQKE-INENSE--LSHLFRLAIQNlDRNEKYQT---VMANLSQGLSLYLMTHHYQAPKSVIDFGLW 74  Streptococcus pneumoni...
Q1GBS6        16 KQLETVanDPA-VKANAA--LSNLIEAAVKKvEKSESIRS---IASNLDTQLRSNFA--ENELPKAVISLQLD 80  Lactobacillus delbruec...
Q5FIQ1        11 NKIEEIvnHDEkVNNNPE--LMEIFRIAYGRrDAGKPIQE---VALALDKALAGYISSHNNNVPESILDLHQE 78  Lactobacillus acidophilus
Q5FI56        43 IKVRELvdSDPdLLGNSD--IMKLVKVALFRaGKNEPVHE---IANELDDGLSGYLAKNDFKAPAGVKKLQAE 110 Lactobacillus acidophilus
CAR41245      18 NEFRKLcnDTE-LKHFPE--LNTLIVTYYDKlNQENKAYFrlkLVAELSNELSYYLLKNRFQAPKSVIDFSLl 87 
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