2ZRR,2FU2,2BL8


Conserved Protein Domain Family
EntA_Immun

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pfam08951: EntA_Immun 
Enterocin A Immunity
Gram-positive lactobacilli produce bacteriocins to kill closely-related competitor species. To protect themselves from the bacteriocidal activity of this molecule they co-express an immunity protein (for discussion of this operon see Bacteriocin_IIc pfam10439). The immunity protein structure is a soluble, cytoplasmic, antiparallel four alpha-helical globular bundle with a fifth, more flexible and more divergent C-terminal helical hair-pin. The C-terminal hair-pin recognizes the C-terminus of the producer bacteriocin and this interaction is sufficient to dis-orient the bacteriocin within the membrane and close up the permeabilising pore that on its own the bacteriocin creates. These immunity proteins interact in the same way with other bacteriocins, family Bacteriocin_II, pfam01721. Since many enterococci can produce more than one bacteriocin it seems likely that the whole operon can be carried on transferable plasmids.
Statistics
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PSSM-Id: 401050
View PSSM: pfam08951
Aligned: 57 rows
Threshold Bit Score: 30.1857
Threshold Setting Gi: 81446420
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ZRR_A        40 IITELLDDLE-IdLGNESLRKVLGSYLKKlkNEGTSVPL---VLSRMNIEISNAIKkdGVSLNENQSKKLKEL 108
Q1GBS6        17 QLETVANDPA-V-KANAALSNLIEAAVKKv-EKSESIRS---IASNLDTQLRSNFA--ENELPKAVISLQLDL 81  Lactobacillus delbruec...
Q5FIQ1        12 KIEEIVNHDEkV-NNNPELMEIFRIAYGRr-DAGKPIQE---VALALDKALAGYISshNNNVPESILDLHQEV 79  Lactobacillus acidophilus
Q5FI56        44 KVRELVDSDPdL-LGNSDIMKLVKVALFRa-GKNEPVHE---IANELDDGLSGYLAknDFKAPAGVKKLQAEL 111 Lactobacillus acidophilus
Q74KH5        11 ILIKAKNQSD-V-VTDLKAQELIEGALEKl-DKKTNVKR---VIFNLKQDINMYSVahGFKLPETLTKLQLLl 77  Lactobacillus johnsonii
Q8CYQ8         9 RVEQLLQQKE-I-NENSELSHLFRLAIQNl-DRNEKYQT---VMANLSQGLSLYLMthHYQAPKSVIDFGLWI 75  Streptococcus pneumoni...
CAR41245      19 EFRKLCNDTE-L-KHFPELNTLIVTYYDKl-NQENKAYFrlkLVAELSNELSYYLLknRFQAPKSVIDFSLli 88  Streptococcus uberis 0...
Q8E1S4        11 QIQHTYNDIS-V-REDAVLSSILLSASNGl-IKTSDVPR---VAYELTQQLENNEIekSFESLATVKELKKSa 77  Streptococcus agalacti...
Q99YJ4        11 VIRQAYDYPE-N-RENVALSQLLLAASNRl-IKHSNPLL---VAYQLNQDVDNYLLdnDILLPKSLCRFKQSL 77  Streptococcus pyogenes...
WP_015911746  11 QIQIAYDYPE-N-RENRQLSSYLLSASNQl-IKNQNPII---IARELNTQIDNYLLqdDSRLSQSLWNLKtal 77  Streptococcus uberis
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