2AUH


Conserved Protein Domain Family
BPS

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pfam08947: BPS (This model is not part of the current CDD release)
BPS (Between PH and SH2)
The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.
Statistics
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PSSM-Id: 518591
Aligned: 7 rows
Threshold Bit Score: 80.3694
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2AUH_B         9 RSISENSLVAMDFSGQK-SRVIENPTEALSVAVEEGLAWRKKGSLRL 54  human
XP_015217420 371 RCVSEASLVAMDFSGKAgGRVIENPREAQSAEQEEGQAWRKKTALRC 417
XP_008995747 365 RSVSDNTLVAMDFSGHA-GRVIENPREALSVALEEAQAWRKKTNHRL 410
XP_040057289 276 RSISENSLVAMDFSGQK-SRVIENPSEALSVAVEEGLSWRRKSCHRL 321
XP_023196390 343 KSESENSLVAMDFTGKAgGRIIENPTEAQNAEQEEAQAWRKRETLRF 389
XP_029700665 377 RSVSENSLVAMDFSGRT-GRVIDNPVEAQSAALEEGQTWR-KRSQRM 421 torafugu
XP_028918361 274 RSVSENSLVAMDFSGQI-GRVIENPAEAQSAALEEGHAWRKRST-RM 318 platypus
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