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Thoeris protein ThsB, TIR-like domain Thoeris is a bacterial antiphage defense system, which consists of two genes, thsA and thsB, via NAD+ degradation. ThsA has robust NAD+ cleavage activity and and a two-domain architecture containing a N-terminal NAD-binding domain (denoted as sirtuin-like or Macro) and C-terminal SLOG-like domain. In some instances, such as in B. amyloliquefaciens ThsA has an N-terminal transmembrane domain. ThsB (also referred to as TIR1 and TIR2) is structurally similar to TIR domain proteins but without enzymatic activity. This is the TIR-like domain of ThsB proteins, which adopts a Rossmann-like fold. ThsB is responsible for recognizing phage infection. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",