8Y0Q


Conserved Protein Domain Family
VP4_2
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pfam08935: VP4_2 (This model is not part of the current CDD release)
Viral protein VP4 subunit
This domain is predominantly found in viral proteins from the family Picornaviridae. It is VP4 of the viral polyprotein which, in poliovirus, is part of the capsid that consists of 60 copies each of four proteins VP1, VP2, VP3, and VP4 arranged on an icosahedral lattice. VP4 is on the inside and differs from the others in being small, myristoylated and having an extended structure. Productive infection involves the externalisation of the VP4, which is cleaved from the rest, along with the N-terminus of VP1. There thus seem to be three stages of the virus, ie a multi-step process for cell entry involving RNA translocation through a membrane channel formed by the externalised N termini of VP1.
Links
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Statistics
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PSSM-Id: 518584
Aligned: 3 rows
Threshold Bit Score: 27.3616
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8Y0Q_4    1 GAGQSSPTTGSQNQSGNTGSIINNYYMQQYQNSMDTqlgDNAISGGSNEGSTDTTSTHTNNTQnndwfsklANTAFSGLF 80   Foot-and-mouth dise...
Q9WJ28  119 GTGTSRMENGNTNNSGNTGVINYNFYSNSYTDAVDL---SGAMSSQESNAAENAASGPTSLLK--------AGINAAARI 187  Porcine teschovirus 1
Q9DLK1  202 GAGQSSPTTGSQNQSGNTGSIINNYYMQQYQNSMDTqlgDNAISGGSNEGSTDTTSTHTNNTQnndwfsklANTAFSGLF 281  Foot-and-mouth dise...

8Y0Q_4   81 GALL 84   Foot-and-mouth disease virus O
Q9WJ28  188 GPLL 191  Porcine teschovirus 1
Q9DLK1  282 GALL 285  Foot-and-mouth disease virus - type O
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