pfam08934: Rb_C (This model is not part of the current CDD release)
Rb C-terminal domain
The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure.
Jiyao W et al.(2023). "The conserved domain database in 2023.",