1XCR


Conserved Protein Domain Family
DUF1907

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pfam08925: DUF1907 (This model is not part of the current CDD release)
Domain of Unknown Function (DUF1907)
The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxH motif that coordinates a zinc ion, and an acetate anion at a site that likely supports the enzymatic activity of an ester hydrolase.
Statistics
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PSSM-Id: 518578
Aligned: 46 rows
Threshold Bit Score: 328.774
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1XCR_A        22 QKGLKDNFADVQVSVVDCP-DLTKEPFTFPVKGICGKTRIAEVGGVPYLLPLVNQKKVYDLNKIAKEI--KLPGAFILGA 98  human
EFN73155      17 QVEFNKFYNEATVKVVNCP-DLRKAPFHLVAPGLCGNTALLEVGSLSNLFPFPRMEKKYDFISFLETSgrSNDDNFIIGA 95 
NP_001232953  37 lpELLDNFENASVEVVQCP-DLTQPPFNLTSEGLCGDENVFDIGDVTNLLPSLKREKLYNVKDLKQIT--GSDPLFIIGA 113
4_pfamImport   1 --ELSNNFETVSVDAVQCP-NLTCSPFNLAAEGLNGDEMVIDIGSPSFLLPLVNLNKVYDIRDFAKVT--GTDPLFVIGA 75 
3_pfamImport   2 KEGLIKNFANVEVEIVDCP-DLTQEPFTLSAPGLSGNSTVLEIGGPSFLLPTVQKNKLYDIQQLLNHLh-YKEDSFVIGA 79 
XP_011149391  31 TDGLTANFEKVIVKLGRCPrDPERQPNQY---DLCGDPTILEIGGPAYLLPLAQKDKFYNIETLLRRId-YHGSAFVIGA 106
XP_011052243  33 AGGLTANFAEATVEIADCP-NFNGWPYNFYREGLCGNPILLEVGGPAYLLPTVQTDKFYDVKSLLRQIn-YNYDTLVIGA 110
XP_011268699  33 AGGLTTNFEEATIEIADCP-DLDEWPYLFYRKGLCGNPIILDIGGPAYLLPTAQKDKFYDIKLILRHLn-YNHDTLVIGA 110
XP_968861     28 NKGLQSNFEHVTVEVVDCP-DLTQQPFTLAKKGLGGSPKLVEVGGVPYLLPLVKREKVYDLKKIATMI--GSDPAFIIGA 104
XP_002429531  24 NEHLKYNFEKVKVEVKDCP-DLTQPPFTLACKGLTGNERIVEIGGVPYLLPKPRKDKLYDLKDLSKIL--NLDPCYITGA 100
1XCR_A        99 GAGPFQTL--GFNSEFMP--VIQT-ESEHk---------pPVNGSYFAHVN----PADG-GCLlekySEKCh-dFQCALL 158 human
EFN73155      96 SLYPSSN---GHMGELIM--NASFsPLDEeg-------mrVKNRSYVAFLAqdhtGENVkLDIlndyNR-----VKCFLH 158
NP_001232953 114 CAGPYPFF--GADSECVE--NVKM-TGDR-----------VENGTHVHMTK----SDDVpECFhkslPDDE---MRFSMM 170
4_pfamImport  76 GAGPWPHV--GVNCEFIG--NVRLtSDDSv---------nNNNSSHLYKVD----PQTGs-QVhhrlPQDE---TRFALL 134
3_pfamImport  80 GAGPWPHI--NSNCELIM--NMVV-SLSN-----------VQNGTHISYVN----KGNGnCELqn-lPNNE---TRFALL 135
XP_011149391 107 GAGLWPHTtdGSNCELIIhhHINT-QIGS-----------VVNNSRYAFVD----KCTGeCVVaqhlSHNEqhqATCPIL 170
XP_011052243 111 GAGPWPHT--GCNCELIM--KLNI--VNDkvspgyrlgmgVANGTHYAFVN----KSNGeCILer-iVANEd-eTTFALL 178
XP_011268699 111 GAGPWPHT--GCNCELIM--KVNI-QVNNkvdp---rnngVANGTHYAFVN----KSTGeCSVtr-vLANEd-eTTFALM 176
XP_968861    105 GAGPHPYA--GVNCEGIL--NMNI---AKg---------vVDQQTRISKVN----PSNEeVPIqeilPNNE---TRVALL 161
XP_002429531 101 GAGPWPYA--GTNCEMII--NMEH-NGDK-----------VNNKTRIAKVN----VTDGk-CIqevlPNDE---CRNAVL 156
1XCR_A       159 ANLFASEGQPGKVIEVKAKRRTGPLNFVTCMRETLEKHYG-NK-PIGMGGTFIIQKGKVKSHIM-PaEFSSCPLN--SDE 233 human
EFN73155     159 GNFFISEGKPGRVLEIHAKARREDKELTKVIQHTLQKYYEaTStLVGLGGTFVVHNGLVRHHLM-P-DIGQISLEncSDE 236
NP_001232953 171 ANFFTSNGFKGEVLKIVCEVRKGPLSYSTCIKEALVKHFG-NE-IIALGGVILIENGKVKVHVIkP-SLTKIPIK--SEK 245
4_pfamImport 135 ANFYTSRGMTGEVLKIVCETRNGPLDFVTSIRKALAKYFG-DK-PVGLGGVILIETSKVKVHVM-P-DFSKIPLD--SEA 208
3_pfamImport 136 ANLFVTEGKPGKVLKIHVKKRVGNDDFIACMQKAIAQNYH-NN-LVGLGGTFLIKNGKVKQHVM-P-DFSATPLR--TEA 209
XP_011149391 171 ANLYVCKGEPGMVIKVYAKKRTGKLDFIASMQKALGNYYK-DE-LVGLGGMFTMRNGKIKQHVM-P-DYSNTPLT--TEA 244
XP_011052243 179 ANLYVCEGKPGKVIKVRAKKRTGNLDFISCMQKALTKHYE-DK-LVGLGGMFEVRNGKVKQHIM-P-AFSDTPLT--SET 252
XP_011268699 177 ANLYVSEGNPGKVIRVRAKKRTGKLDFISCMQNALENHYK-DN-LVGLGGMFVMKNGKIKQHVM-P-NFSDTPLN--TET 250
XP_968861    162 ANLFFSSGEPGKVLKIHAKKRTGPLDFIASIRQTLVNEYK-NK-VVGLGGAFLLKEGKAKQHVM-R-DFSKTPIN--TDE 235
XP_002429531 157 SNLYCSSGEQGKVLEISCSKRIGNDDFITSIRKILGENFK-DK-ILGLGGVFVIKKGKVKQHVM-P-DFSNREIS--SED 230
1XCR_A       234 E-VNKWLHFYEMKAPLVCLPVFVSRDP------------GFDLRLEHTHFFSRHGE--GGHYHYDT-TPDIVEYLGYFLP 297 human
EFN73155     237 SrIRNWVKTRILTTPLVAVGTIVNKSSfpvvltnsklqtDLQLTTNHFHSFS-FEPlvGGHYYTNVeYGNSAEYLGYFCP 315
NP_001232953 246 E-LGNLLHFIELSPPLVGVGCIVSHDP------------GLNLRLQHFHLYTDHNQ--GGHYYNDT-EPETIKYTGYFGV 309
4_pfamImport 209 D-LNNWLKFFEVSTPLVALGYLVSHDP------------GLDLRPQHFHLFGNHGE--GGHYHHDT-EPTTVKYTAYLNV 272
3_pfamImport 210 Q-LNNWLHFYNMSTPLIAVGTFVSSES------------DLDLRVQHFHSFSHHGE--GGHYHIDT-TPETIEYLGYFNL 273
XP_011149391 245 Q-LNDWLHFYEMKTPLTAVGTFVSAET------------ELDLRVQHFHSFAHNNKm-AGHYHIDT-TPDTIEYEGYFNI 309
XP_011052243 253 Q-LNNWLRFYDMKTPLIAVGTFVSAET------------DLDLRVQHFHSAFDENRl-GGHYHIDT-TPDTIEYEGYFNV 317
XP_011268699 251 Q-LNNWLHFYDMETPLVAVGTFVSAET------------DLDLRVQHFHSASNENQl-GGHYHIDT-TPDTIEYEGYFNV 315
XP_968861    236 E-LNNWLKFYNMRAPLVAVGTLINNDH------------GLDLRVQHFHSFSHHGE--AGHYHIDV-TPETAEYLGYFNT 299
XP_002429531 231 D-LNKWLKFYEMNTPLIAVGTLVNNDP------------GLDLRVQHFHSFSHHGE--GGHYHIDT-TPNDVEYLAYFGL 294
1XCR_A       298 AEFLYRI 304 human
EFN73155     316 AKKLYRL 322
NP_001232953 310 SKQFTKi 316
4_pfamImport 273 AKKLIRV 279
3_pfamImport 274 GTTLYRI 280
XP_011149391 310 ASVLYRV 316
XP_011052243 318 AATLYRV 324
XP_011268699 316 ATTLYRV 322
XP_968861    300 GEEIYRV 306
XP_002429531 295 GEKLYRI 301
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