6QX9


Conserved Protein Domain Family
SF3b1

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pfam08920: SF3b1 (This model is not part of the current CDD release)
Splicing factor 3B subunit 1
This family consists of several eukaryotic splicing factor 3B subunit 1 proteins, which associate with p14 through a C-terminus beta-strand that interacts with beta-3 of the p14 RNA recognition motif (RRM) beta-sheet, which is in turn connected to an alpha-helix by a loop that makes extensive contacts with both the shorter C-terminal helix and RRM of p14. This subunit is required for 'A' splicing complex assembly (formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA) and 'E' splicing complex assembly.
Statistics
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PSSM-Id: 518573
Aligned: 43 rows
Threshold Bit Score: 103.228
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6QX9_B1       332 SKRKSRWD------ETPASQM-------------------GGSTPv---lTP-----GKTPI-------Gtp-------- 363  human
A0EEP7        151 SARASRWDntnklqATPGRAGt-----------------vFGETP-----TPghmeiGDTPYkygetptPnhgekehlwl 208  Paramecium te...
Q4UCL9        138 KKKVSRWD------KTPMm-------------------------------------eQQTPMaht--------------- 159  Theileria ann...
Q7RM47        221 KKKISRWD------RTVENSTssnnnnnfgdgkmassgmnQLKTPiisgnKYnenmiINTPIl----------------- 277  Plasmodium yo...
EME38464      240 ATKKSRWD------STPA-------------------------LDggaapAKkkskwDLVSAgeqttqvQp--------- 279 
CCG81011      308 TTKRSRWD------ETPV--------------------------Pvn-gaSTkrsrwDQTPA------------------ 336 
XP_003839021  223 SSKRSRWSep---ePEPE-------------------------KPae-daAPvrsrwDTTAV------------------ 255 
XP_014081488  219 PKKRSRWS------PAPE-------------------------DTke-aaAParsrwDTTAV------------------ 248 
KDE09112      258 KKKRSRWD------ETPAQAAt-----------------aGSGAPg---eTPrrsrwDQTPV------------------ 293 
XP_001831366  178 KKRRSRWD------AAPPD----------------------VQQPa---eTPkrsrwDQAPA------------------ 208 
6QX9_B1       364 ----aMNMATPtpg-----------himSMTP-------EQLQAWRWEREIDERNRPLSDEELDAMFP---EGYKVLPPP 418  human
A0EEP7        209 vnhgfGGGMTPhtpgtvmrtpmtpgqlgNMTP-------DRVYQFRLEKEMEERNKYMTDEELTSILPgpkDGYEILRAP 281  Paramecium te...
Q4UCL9        160 ---gmYGMATP------------------MTPqiv--vpESMLKFNITTSYEDRNRYLTDEELDELLPv--EGYEIVLPP 214  Theileria ann...
Q7RM47        278 ----gTNIMTP------------------ITPysgsvqnNDYIKIKIKNEMDYRNRPLTDEDLDNLLPi--DGYEIVKPP 333  Plasmodium yo...
EME38464      280 -------nAAP------------------AQP-----------MAGFGTDISGRNAALSDEELDEMLPs--eGYKILDPP 321 
CCG81011      337 ----------Pgsvs----------akqVTAP-------AAVIPTSFGTDVAGRNLPLSDEELDELLPk--tGYKILIPP 387 
XP_003839021  256 ---------VPasatpaap--aangahpVMPP-----------TFAFGTDISSRNAPLSDEQLDMMLPgeaEGYKVLEAP 313 
XP_014081488  249 ---------APaatatpap---aangahpIAP-----------TFAFGTDISSRNAPLSDEQLDMMLPgeaEGYKVLEPP 305 
KDE09112      294 -----GVAQTPnaag----------lygAMTPfkgatgsNASIPG-AGQLIDPRNRYLSDEELNQMLPt--EGYEIVDPP 355 
XP_001831366  209 ------VQDTP------------------MQP-------IIMNAPGVMHE-DKHNRYLTDEELDALLPt--SGYAIVTPP 254 
6QX9_B1       419 AGYVPIRTPARKLT------ATPT-PLGGM---T 442  human
A0EEP7        282 ENYKPLRSSLKKLLnakdsiESPVqyqipesiri 315  Paramecium tetraurelia
Q4UCL9        215 PDYQPYRKPSSYTY------GTVT-PHftipddv 241  Theileria annulata
Q7RM47        334 EEYETIRKNKLKILfknmndTTTT-PLIQGnknv 366  Plasmodium yoelii yoelii
EME38464      322 PGYEPLRAPARRLA-----------PSATPvntG 344 
CCG81011      388 PGFEPIRAPAKRVQ------VEDAd--------G 407 
XP_003839021  314 PGYEPVRRPV----------GMPVlPTGY----Q 333 
XP_014081488  306 PGYEPVRRPV----------GMPAlPTGY----Q 325 
KDE09112      356 AGYAPIRTPARKLQ------ETPM-AMNGGgfim 382 
XP_001831366  255 PGYAPLVAP-RNLM------ATPVtk------iE 275 
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