1ZZP,2KK1


Conserved Protein Domain Family
F_actin_bind

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pfam08919: F_actin_bind 
F-actin binding
The F-actin binding domain forms a compact bundle of four antiparallel alpha-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function.
Statistics
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PSSM-Id: 401025
View PSSM: pfam08919
Aligned: 26 rows
Threshold Bit Score: 90.8361
Threshold Setting Gi: 470271670
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1ZZP_A         23 GAITKGVVLDSTEALCLAISRNSEQMASHS---------AVLEAGKNLYSFCVSYVDSIQQmRNKFAFREAINKLENNLR 93  
XP_004362906   56 yvvllQKIVKSINDLTTALDNLAKSgmil-------tirTVADLITQLLQESNNIASSIPEgKAKFNFLEAVSKCKSSSL 128  Cavenderia fa...
XP_005479196 1099 ERVNREVLLECAECLSSALHASSESPSSSQ----------VLDAGHQLLDYCSGYVDCIPQmRNKFAFREAVGKLELSLQ 1168 Nile tilapia
NP_001116177 1028 EKISKEALLECAECLSSALQGNSELSSSSQ----------VLDVGHQLLDYCSGYVDCIPQtRNKFAFREAVGKLELSLQ 1097 zebrafish
XP_006005125 1072 DKISKKALLECAELLASAISGGPEPTTNSQ----------LVDTGHQLLDYCSGYVDCIPQtRNKFAFRDAVSKLELSLQ 1141 coelacanth
P42684       1082 DKISKEALLECADLLSSAL---TEPVPNSQ----------LVDTGHQLLDYCSGYVDCIPQtRNKFAFREAVSKLELSLQ 1148 human
XP_005172105  960 STITRDMLLESSELLRTAIARVSEQTGSHS---------AVLEAGKNLSKYCVSYVESIQQmRNKFAFREAINKLESSLR 1030 zebrafish
XP_008122344 1005 GAVTKDTILESAETLRTAISRNSEQMASHS---------AVLEAGKNLYTFCAGFVDCIQQmRNKFAFREAINKLENNLR 1075 green anole
P03949       1112 EPVSKDMIVSLLKVIQKEFVNLFNLASSEItdeklqqfvIMADNVQKLHSTCSVYAEQISP-HSKFRFKELLSQLEIYNR 1190 Caenorhabditi...
2KK1_A         35 DKISKEALLECADLLSSAL---TEPVPNS----------QLVDTGHQLLDYCSGYVDCIPQtRNKFAFREAVSKLELSLQ 101 
1ZZP_A         94 ELQ--ICpAT--AGSgPAATQDFSKLLSSVKEISDIVQR 128 
XP_004362906  129 QLKinISv----RAS-SSEDDDTKELDGKILELYRIVaq 162  Cavenderia fasciculata
XP_005479196 1169 ELRasSSgGGg-LGG-VGSNTVLDNLHSCIKEISDVVQR 1205 Nile tilapia
NP_001116177 1098 ELRacSTgGGvgLSG-PGTSPALDNLHMCIKEISDVVQR 1135 zebrafish
XP_006005125 1142 ELQvsSTgSS----G-PGTNPLLSNLLTCIKEISDVVQR 1175 coelacanth
P42684       1149 ELQvsSAaAG----V-PGTNPVLNNLLSCVQEISDVVQR 1182 human
XP_005172105 1031 ELQicPAaT----GT-ANTPQDFSKLLCSVKEISDIVQR 1064 zebrafish
XP_008122344 1076 ELQicPAtAG--GGG-PAATPDFSKLLGSVKEISDLVQR 1111 green anole
P03949       1191 QIK--FShNP--RAK-PVDDKLKMAFQDCFDQIMRLVDR 1224 Caenorhabditis elegans
2KK1_A        102 ELQ--VSsAA--AGV-PGTNPVLNNLLSCVQEISDVVQR 135 
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