Conserved Protein Domain Family
PhoQ_Sensor
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pfam08918: PhoQ_Sensor (This model is not part of the current CDD release)
PhoQ Sensor
The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane. This domain recognises divalent metal cations, and antimicrobial cationic peptides .
Links
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Statistics
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PSSM-Id: 518571
Aligned: 10 rows
Threshold Bit Score: 310.443
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7N3B1         8 PFSLRTRFLMATAAVILALTMSYGIVAIVGYLVSFDKTAYTLLRSQSNLFFSLAQWNNNQLDISVPPNFTLNNPSLVLIY 87  Photorhabdus la...
WP_002440279  10 PLSLRVRFLLATAAVVLVLSLAYGVVALLGYSVSFDKTTFRLLRGESNLFYTLARWEDGKITLDVPEHLDLQSPTLTFIY 89  Shimwellia blattae
1_pfamImport   1 PLSLRVRFLLATAGVVLVLSLAYGMVALVGYSVSFDKTTFRLLRGESNLFYMLARWENGAIDVDIPENLNMESPTVTLIY 80 
WP_013318098   5 PFSLRFRFLIATAAVVLALTLSYGIVAVVGYSVSFDKTSFRLLRGESNLFYSLAQWHDNQLTIATPPEIDINYPTLVFIY 84  Dickeya dadantii
Q6D4E5         7 PFSLRIRFLLATAAIVLALSLAYGVVAIIGYSVNFDKTSFRLLRGESNLYYSLAQWRDNQLNIVTPPDVDINFPTLVLIY 86  Pectobacterium ...
BAN98408       9 PFSLRARFLLATAAIVLFLSLSYGMVAVIGYVVSFDKNTYRVMRGESNLFFTLAQWKDNKLTIAQPERMTLNFPTLVFIY 88 
3_pfamImport   1 PFSLRTRFLLATFAVILAMTLSYGAVALVGYLVSFDKTTYTMLRSQSNLFYSLSQWDDGKLNIRFPPNFSLNAPSVVLIY 80 
WP_269146836   9 nVSLRTRFLMATIVIILALTLSYGIVAIAGYLVSFDKTNYSILRNQSDLFFMLTKWDNNKLKVLVPKNFSMNSRSLALIY 88  Xenorhabdus nem...
WP_002210918   8 PFSLRARFLMATAGVILALSLSYGMVAVVGYIVSFDKSTFRAHRGESNLFFSLAQWHNNKLSISVPPELELNVPSLVLIY 87  Yersinia pseudo...
P0DM80        10 PLSLRVRFLLATAGVVLVLSLAYGIVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKISVELPENLDMQSPTMTLIY 89  Salmonella ente...

Q7N3B1        88 NNKGAILWRQHHIPKVENSIPSEWLKEDGLYELDTDLKSSRDLL-KNSANTQGQLGKLNsldENEDNELTHSVSVNRYSA 166 Photorhabdus la...
WP_002440279  90 DEHGKLLWSQRQVPWLEKHIKPEWLKSNGFHELEASYASSRVLV-GNNHAVQRKLSDIHd--DDSDEELTHSIAVNRYPA 166 Shimwellia blattae
1_pfamImport  81 DEQGKLLWAQRDVPWLAKRIQPEWLKRNGFHEIEADVDSSSMLL-RNNHEIQEQLDAIRe--QGDDSEMTHSVAINLYPA 157
WP_013318098  85 DKHGKLLWRERAVPELESQIKPEWLEKTDYHELDADTNTSNAVLqGSNPQMLDKLHAYS---SEDKTPFTHSIAVNVYPA 161 Dickeya dadantii
Q6D4E5        87 DENGNVLWREKHVPELEALIKPEWLNKTAYHELDTDTDTSSAVL-TGNTLLLSSLRALN---GAHSNALTHSIAVNVYPK 162 Pectobacterium ...
BAN98408      89 DERGKLLWQQRDMPEIRKNIRRDWLMKPDFYEIDTSNRTSMAAM-GNNPQAQQRLHALD---SDSNDTFTHSVAVNRYDA 164
3_pfamImport  81 DDNQNLLWRQYHIDALERAIPAKWLTKEGLYDLNTSLEATKSLL-VNTPLFATEDIRINdldDDHDGRMIHSVSVSRYGK 159
WP_269146836  89 DNEGNILWRQNNVPELEKMIDPNWLKKNGLYELEVYFKEKDDLI-YNKALNQKDTKKTE---GDNHVLLTYSVAVNIYSA 164 Xenorhabdus nem...
WP_002210918  88 DKDGNILWRQRHVPELESHIEKSWLQKPGFYELDTGTHISRMMM-GDNPKAQDQLKKYD---DTDDSALTHSVSVNTYAA 163 Yersinia pseudo...
P0DM80        90 DETGKLLWTQRNIPWLIKSIQPEWLKTNGFHEIETNVDATSTLL-SEDHSAQEKLKEVRe--DDDDAEMTHSVAVNIYPA 166 Salmonella ente...

Q7N3B1       167 TAHLPALTIVVIDTIPQDLQKTV 189 Photorhabdus laumondii subsp. laumondii
WP_002440279 167 TGIMPALTMVVVDKIPIELKRSY 189 Shimwellia blattae
1_pfamImport 158 TSKMPQLSIVVVDTIPVELKRSY 180
WP_013318098 162 SERLPKMVIVVVDRVPQELQQAD 184 Dickeya dadantii
Q6D4E5       163 TDHLPSITIVVVDRIPQELQQED 185 Pectobacterium atrosepticum
BAN98408     165 TTNLPALTIVVVDSIPQELQHSD 187
3_pfamImport 160 TDTLPPLTIVVVDTIPQNLQKT- 181
WP_269146836 165 TETLPAMTIVIIDTIPQDVQESs 187 Xenorhabdus nematophila
WP_002210918 164 TSRLPQLTIVVVDTIPQELQRTD 186 Yersinia pseudotuberculosis complex
P0DM80       167 TARMPQLTIVVVDTIPIELKRSY 189 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
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