pfam08918: PhoQ_Sensor (This model is not part of the current CDD release)
PhoQ Sensor
The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane. This domain recognises divalent metal cations, and antimicrobial cationic peptides .