4RR8


Conserved Protein Domain Family
tRNA-Thr_ED

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pfam08915: tRNA-Thr_ED (489995 is an unknown moldel)
Archaea-specific editing domain of threonyl-tRNA synthetase
Archaea-specific editing domain of threonyl-tRNA synthetase, with marked structural similarity to D-amino acids deacylases found in eubacteria and eukaryotes. This domain can bind D-amino acids, and ensures high fidelity during translation. It is especially responsible for removing incorrectly attached serine from tRNA-Thr. The domain forms a fold that can be be defined as two layers of beta-sheets (a three-stranded sheet and a five-stranded sheet), with two alpha-helices located adjacent to the five-stranded sheet.
Statistics
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PSSM-Id: 489995
Aligned: 71 rows
Threshold Bit Score: 158.468
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RR8_A         1 MRLLYLHADRFEYKTVKPALKNPPDPPGEASF-GEALVVFTTVEDGDGP---QTVMYAASDIASHSSRLKVTTVILYPYA 76  Aeropyrum perni...
WP_012663148   3 MRVLFWYCDNFDWNPAIKTIEEVPDAQPFGC--TNAVVAFIHVEPKDLDpasSAETKLVKNSKWLARKWSVNQIVLHSFT 80  Desulforapulum ...
WP_006930409   1 MRLLMIYCTKFAYKTSVKGLEQVDELHESAQF-ENALVGFIHVEPDDEQhlsTVQTKLVKNLKWAARKNETNRIVLHSFA 79  Caldithrix abyssi
WP_013908036   1 MKIIMFYALEFSWKPYQKVLDSGEDTPKETSL-SKTVVVFYQVEAEDPArekKVVEKLIKNIKWLARKFDTKAVVLHSFN 79  Thermodesulfata...
WP_014260807   1 MKLLMFYAPEFWHKPFQKTLPEAPEAEPTGAMaRDAVVVFYHGEAEDHDrrsSVLSKMLKNIKWLGGKFNTKQVVLHSFG 80  Desulfocurvibac...
WP_013258214   1 MKLLMFYAPSFWFKTHEKALAEAPEADIEQTV-EHAVVVFYQVEAHDVDdqtATINKTIKNIKWLSRKFQAGAVVLHSFN 79  Desulfarculus b...
WP_011697057   1 MKLLMFHAPEFWFKTFDKAIPDAPDCKEEKSF-RQAVVIFYQVEGEDVGredGIVSKWVKNAKWIAGKFATRTVILHSFN 79  Syntrophobacter...
WP_013036622   1 MKMLLFDTEYFWFDTFSKTLENVEDIKKEEKI-ENTAVVFIHVELEDEErknKVVKNAVKTFKWYLNKVDKEKIVLHSFA 79  Methanohalophil...
WP_012107602   1 MKLLMFDTNEFWYKPFQKTLETAQTAVDEAAF-ADSLVIFVNVEEEDELqkdKSIRKAAENILWLAKKTGRTKVVLHSFA 79  Methanoregula b...
WP_012617811   1 MKLLMFNTHEFWFRTFKNSLNEDNDEDIEKTV-ENSLVIFIHIEENDIErkeRLVKKATDNITWLAKKTGRKRVVLHSFA 79  Methanosphaerul...
4RR8_A        77 HLSSRLAKPMAAHKRLIELEGALRTK-FpgHVHRAPFGWYKSFSIACKGHPLAELSRS 133 Aeropyrum pernix K1
WP_012663148  81 HLGEEKADPDMAQAVLNNAQVRLETSgY--DTIQTPYGYFLDLSIKAKGHPLARIYKE 136 Desulforapulum autotrophicum
WP_006930409  80 HLSEEKGDPELTKKIFDNAEERLKSAgY--ETAQTPFGYFLDIDVQAPGHSFARLFKE 135 Caldithrix abyssi
WP_013908036  80 HLSSSKASPEESYAIIEKAKEKLKRTgF--NIYETPFGWLNEWKMHVAGESLAKVFKE 135 Thermodesulfatator indicus
WP_014260807  81 HLSESKADPEFVRELVAEVRQRLENTgY--SVGETPFGYLNEWKLHVAGDSLAKVFKS 136 Desulfocurvibacter africanus
WP_013258214  80 HLSASKAPPQAAQALMEAAAQRLAAVgL--TVQQTPFGYLNEWRLHAAGPALAKVFKE 135 Desulfarculus baarsii
WP_011697057  80 HLSLSKAPPETAHRLAAQVRGRLERAgF--SVFETPFGYLNEWKLHVSGESLAKVFKE 135 Syntrophobacter fumaroxidans
WP_013036622  80 HLSSSTSSPEFAAEIISEIKEKLINKgI--EVHTTPFGYFSEFSIHVRGESLAKIFKE 135 Methanohalophilus mahii
WP_012107602  80 HLSESKSGIGFAEAALQGIRDRLAAKgL--TVAITPFGYFLEFKIHVKGESLAKVWKS 135 Methanoregula boonei
WP_012617811  80 HLSDSKSESTGAQDIFLALQEKLISRgL--DTTMTPFGYLNEFRIQVLGDSLAKVWKS 135 Methanosphaerula palustris
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