Conserved Protein Domain Family
Myb_Rap1
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pfam08914: Myb_Rap1 (This model is not part of the current CDD release)
Rap1 Myb domain
This entry represents the Myb domain found in telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) from animals and DNA-binding proteins RAP1 from yeast. These proteins are involved in the regulation of telomere length, clustering and have a specific role in telomere position effect (TPE). This domain binds DNA in Saccharomyces cerevisiae, but not in animals and Schizosaccharomyces pombe where it may either interact with DNA via an adaptor protein or it may be only involved in protein-protein interactions.
Links
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Statistics
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PSSM-Id: 518567
Aligned: 59 rows
Threshold Bit Score: 51.3978
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
RMJ23742      79 FTLEDDQILWDWMQPYERdPGAPVHGYTIYKKLAEKtltiviaqHPKHTFQSWRDR-AKKLRGRPRPG 145
6_pfamImport   1 FTEAEDEAILLYVRARAR-G--TASGTALWKEMARVr-------LTPHSWQAMRDRyLRHLRGQEEKY 58 
2_pfamImport   1 FTGSEDQAILLHVRERAQ-G--SGTGTALWKEMERAr-------LTPHSWQAMRDRyLRHLRGQEHKY 58 
3_pfamImport   1 FSAEEDAALLSAVRGRGE-A--RVLGRALWQELERAg-------LTRHSWQAMRDRyVRYLRPAQRER 58 
XP_010850182 138 FTDADDVAIITYVKEHAR-SASSVTGNALWKAMEKSs-------LTQHSWQSMKDRyLKRLRGQEHKY 197
XP_004470975 135 FTHADDVAILTYVKENAR-SPNSVTGNALWKAMEKSs-------LTQHSWQALKDRyLKHLRGQEQKY 194 nine-banded armadillo
XP_028930839 145 FTDAEDTAILTYVKENAK-SPSSITGTTIWKAMEKIa-------LTQHSWQSMKDRyVKHLKGQEHKY 204 platypus
XP_035676983 119 FERYESINILMYIAKHGG-EKPPVSGKKMWKDMQLFk-------VTKHPWSSMRSHyLKQLRGNEEEY 178 Florida lancelet
NP_001384203 102 FTEAEDAALLRAVRERSG-A--RVSGTALWKELECTg-------LTRHSWQAMRDRyLRHLRPLHWES 159 chicken
XP_006003445 199 YTRAEDVAILMYLRDHKA-GQTSVKGNAVWMEMERIs-------LTRHSWQSMKDRyMKKLRGQEDKY 258 coelacanth
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