1UIX,1S1C


Conserved Protein Domain Family
Rho_Binding

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pfam08912: Rho_Binding (This model is not part of the current CDD release)
Rho Binding
Rho Binding Domain is responsible for the recognition and binding of Rho binding domain-containing proteins (such as ROCK) to Rho, resulting in activation of the GTPase which in turn modulates the phosphorylation of various signalling proteins. This domain is within an amphipathic alpha-helical coiled-coil and interacts with Rho through predominantly hydrophobic interactions.
Statistics
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PSSM-Id: 518565
Aligned: 32 rows
Threshold Bit Score: 43.8028
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UIX_A           3 TSDVANLANEKEELNNKL----KEAQEQLSRLK-D---EEISAAAIKaqfeKQLLTERTLKTQAVNKLAEIXNRKE 70   domestic cattle
EEC13851       845 EKDRAVRDLELEQLHKQLvserSSHESALEQERaEraaEAARQEQLQ----KQLHQERLLKQVAVNKLAEVMNRKD 916 
XP_002431014   944 KKQLDQMSKEREEMTRQL----RHVQEDMKKRT-N---QDEEVERLN----RVLKQEIVLKQQAVNKLAEIMNRKD 1007
2_pfamImport     2 KKMNEHLSKEREDINRQL----KQLQEEFSKKS-G---NNEEIDKLK----SKLQTESLLKQQAVNKLHEVLNRKD 65  
NP_001265264   943 KKNVDQYLKEKEDLNKRF----KELQDQLSKAQ-S---NAEEIEKLS----SKLKTEQLLKQQAVNKLAEIMNRKD 1006
XP_046456283   965 KKTFDLVTQENQDLGAKL----KSAQEELAQAStA---SVDEVERLR----VKLKQEQLLKMQAVNKLAEIMNRRD 1029
17_pfamImport    2 KKRIDELIKDNEETNNQK----KIMEEDIRNAK-A---CMEESERLH----KQLKQEQLLKAQAVNKLAEIMNRKD 65  
3_pfamImport     2 KKKMEQLIKDNEELKNQL----TIIQEESKKN------FIEELEKLR----KQLKQEQLLKAQAVNKLAEIMNRKD 63  
XP_002117911   144 KNDKYEMALRITQLKAEV----RFVEDSEENAI-----LSKQIEKLR----ESLSAEQLLKTQAVNKLVETLNCKL 206 
XP_032289261   953 HKKLKQKASEWDELLVQH----KKQLDELQQQRaA---KDEEIAKLG----EKCKNEVLLKQVAVAKLAEVMNRRD 1017
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