3TJ3


Conserved Protein Domain Family
NUP50

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pfam08911: NUP50 (This model is not part of the current CDD release)
NUP50 (Nucleoporin 50 kDa)
Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localisation signals from importin-alpha.
Statistics
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PSSM-Id: 518564
Aligned: 71 rows
Threshold Bit Score: 34.5952
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3TJ3_C          7 AKRNAEKELTDRNWD----------QEDE--AEEVGtFSMASEEVLKNRAIKKAKRRNVGf----------eSDTGGAFK 64   human
XP_011272245    3 GKRRADNQVTRENLHeh-------eRSDDddEAPKGpTL-ASADVLAKRKILKPRSRLnraag-----agsaASSAAPSS 69  
XP_002551211    2 AKRVADEQITKDGFE----------GSSDgdDAPQGpVQ-ASNDVLSKRKILKPRGRLGTqpsgssgfngfsNVQMPQSS 70  
KAJ9098392      2 AKRTAEDQITRETYG----------TGEAddESFSGpSK-ASSAVMSRRKILKPRGHRGTsdi---------stNTATTP 61  
4_pfamImport    1 SKRGATQQLSKEGTFfg------dgSNDLsgDDKPRk---ATAAQLANRKLKPLKGRPRVagstt--aqsfpPASQPSSN 69  
XP_007673877    2 SKRLAESQGGEERYGksneggmtgsQDRApqA--------ATAAQLARRKIIQARGRVSArgsr----apspATGPQQSN 69  
CBJ27957       10 VKRTAEHQINKDEdp---------eGDGVgqEVEAGtFQRAPAEVLKTRKIVKVRSRSPAeq---------pPAAAASAN 71  
XP_018507999   12 KKRGALKQLSRENPDd---------DEDVsaDFESGtFKKASDEVLASRRIVRIKRKEPSaa-----------pPAATTN 71  
Q9C829         12 KKRGALKQLSRDNPGl--------dDDDDsaELESGtFKKASDEVLASRRIVRVKRKEPSaa------------pVAASN 71   thale cress
XP_020886235   12 KKRAALKELSRDNPGl--------dDEEDtsALESGtFKTASEEVLASRRIIRVKRRDPSaa----------aAPAPTSN 73  
3TJ3_C         65 GFKGLVVP 72   human
XP_011272245   70 GFSFGAST 77  
XP_002551211   71 SFSFGNGN 78  
KAJ9098392     62 SFSTFKNE 69  
4_pfamImport   70 AFTGFAPT 77  
XP_007673877   70 PFQTFQAP 77  
CBJ27957       72 PFASLGSA 79  
XP_018507999   72 PFAGIQLL 79  
Q9C829         72 PFAGIQLV 79   thale cress
XP_020886235   74 PFAGIRLV 81  
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