3K1T


Conserved Protein Domain Family
GshA

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pfam08886: GshA 
Glutamate-cysteine ligase
This is a rare family of glutamate--cysteine ligases, EC:6.3.2.2, demonstrated first in Thiobacillus ferrooxidans and present in a few other Proteobacteria. It is the first of two enzymes for glutathione biosynthesis. It is also called gamma-glutamylcysteine synthetase. The structure of this family has been solved, and is similar to that of human glutathione synthetase and very different to gamma-glutamylcysteine synthetase from Escherichia coli.
Statistics
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PSSM-Id: 489967
Aligned: 30 rows
Threshold Bit Score: 544.905
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3K1T_A           19 EKRLLDNXPRIEHWFRSQWQEYGAPFYASVDLRNAGFKLAPVDTNLFPGGFNNLNPDFLPLCIQAAXVAVEK-ICPDARR 97  Methylobacil...
WP_012823404     25 eSHIIRCHRQIEAWFRAQWLKHPAPFYASVDLRNAGFKLAPVDTNLFPAGFNNLNHIFDPVMVQAIQAAVEH-SCPEAKD 103 Halothiobaci...
Q83AL1           22 EKLFFQHQVDIESWFRKQWLKTPPPFYTSVDLRNAGFKIAPVDTNLFPAGFNNLNPDYMPLYIQAVQATIAE-ICPDVTR 100 Coxiella bur...
Q5ZUF1           23 EKIILNKLAEIESWFRKKWQETPAPLTSSVDLRHAGFKLAPVDTNLFPAGFNNLNPEFLPLCIQAAQSALIE-YIPDCTK 101 Legionella p...
5_pfamImport      1 EKVILSQVAVIEAWFRRQWQKTPPPITSSVDLRHAGFKLAPVDTNLFPAGFNNLNRAFMPLCIQAVQSVLGE-SYPNCTK 79 
4_pfamImport      1 EQHLITEQCAIERWFRCQWQKTPPPFYASVDLRNAGFKLAPIDTNLFPAGFNNLNPEYAPLYVSAVQHYLAQ-YHPGLER 79 
Q6MH05            7 hKQTLANMNEICAWFASKTANMSYPIYSSYDIRDSGYKISNVDANIFPAGFNNICPTDKESAPALVDKYITKhYGANIKN 86  Bdellovibrio...
WP_014245543     12 eKFVSEHWNDINTYFDTKFEKRTTPIYSSVDIRESKDKIAPVDHNMYPAGFNNLCQLDLSYATEVFEESLKS-INSEIQH 90  Halobacterio...
wsu_vmp:AMF_895   8 eDVLERRAAAVEDWFADWFSRYPAVLSTSVDVRSSGYKIAPVDVNFFPAGYNNFGVDARQRAESAFLEHLSQ-YL--GSK 84 
Q2GHY0            9 nDILTKYKLDIENWFFNKFTKYNPVLNISVDLRVSDYKIAPVDTNIFPAGYNNFTEQSQIYASRLLREYVVN-YA-NCSK 86  Ehrlichia ch...
3K1T_A           98 LLLIPENHTRNTFYLRNVHALTHILRQAGLEVRIGSIAPEITAPTFL-ETHDGHSILLEPVRR---KANRL-ELDNFDSC 172 Methylobacil...
WP_012823404    104 ILIIPERHTRNLFYLESLAALVAFVEMAGFGVRIGSLEP-ITEPVNF-DLPSGRTLTQHPICR---VGKRI-EVDGFSPC 177 Halothiobaci...
Q83AL1          101 LLLVPESHSRNIYYLESLGALTEILKKAGFEVRIGSLDESQKEPRTH-ELPSGQQLLIEPLLR---KGDQV-GVKDFFPC 175 Coxiella bur...
Q5ZUF1          102 ILLLPESHTRNKYYLQSLNVLKTIFVKAGFIVRIGSLDPDIKEPTEI-ILEQGETLLIEPLQR---QGDKV-GLDNFSPC 176 Legionella p...
5_pfamImport     80 ILILPESHTRNRFYLHSLSVLRDIFVKAGFVVRIGSLDTTMTVPVEV-VTDDGEVLLIEPLLR---VGNKV-RLAEFDPC 154
4_pfamImport     80 VLLLPENHTRNGFYLENVARLAELLEQAGLNVRVASL---RGEAQEL-ELPSGGRLRLEALER---HGDHL-QAGDFLPE 151
Q6MH05           87 IMLVTEEHTNNAFYWENVHTIRKLIEATGRVVKV-AIPRELPEPLNL-TSSAGNEVVVHSALK---GGELL---KSFTPD 158 Bdellovibrio...
WP_014245543     91 IGIIPESHTKNLFYLDHLAMLGKAIRDAGFEVTFLSFDNNLFQDENTlNLISHSQFDLQ-ISKaelKDGEI-YAADQKMD 168 Halobacterio...
wsu_vmp:AMF_895  85 VLIVVESHTRNKKYVDSVMALKDILGASGFQLEVGACG--ITEDMSA-VSSTGATLDVKALVN---CGGEVsTTSGFVPD 158
Q2GHY0           87 ILIIAENHTRNLKYIDSLIVLKNIVNNAGFVVEVGICN--INQNIEL-ISSTGRVINCLCLTN---DNGVLrAGCRFIPD 160 Ehrlichia ch...
3K1T_A          173 AILLNNDLSGGIPDILQGL-EQSLIPPLHAGWATRRKSNHFTAYDRVVEEFAPLIDIDPWLLNPYFDTCGGLDFHARLGE 251 Methylobacil...
WP_012823404    178 TILLNNDLSGGRLEILDDL-EQTVIPPIELGWWKRSKFEHFSIYQDLTRELCATIDLDPWYLSPLMRDCGHIDFLKREGE 256 Halothiobaci...
Q83AL1          176 CVILNNDLSGSIPDIFQNV-NQWIMPAPQLGWAMRLKSGHFRAYAEVAEEFAAMIDIDPWLISPLFDQCPEVNFLKKEGE 254 Coxiella bur...
Q5ZUF1          177 LLLLNNDLSSGVPEILQDV-QQRIRPTAKLGWASRLKSSHFQFFEEVAIEFAELVGIDPWLINPYFSAIEGVDFMAQEGI 255 Legionella p...
5_pfamImport    155 LLLLNNDLSSGIPDSLQDL-QQPIQPTAKLGWASRLKSSHFHCFAEIAEEFAALVNMDSWLICPAFNAVNGIDFMAQEGI 233
4_pfamImport    152 LILLNNDLSGGTPPLLEGL-AQTILPPLAAGWRTRRKSQHFAHYRRLAQELGEVIDIDPWLIDPIFRRCQGIDFMRAEGR 230
Q6MH05          159 LIISNNDFSEAYEEWAPTMiDFPMNPPRELGWYQRKKSTYFKYYNQLASEFAEVAQIDPFLLRVETELFEHFDIGDENSR 238 Bdellovibrio...
WP_014245543    169 LVVLNNDQSDPIELDWKAV-KTPINPTPLIGWFARQKNKHFTYYKNCVEEFSKNFDINPDILQAKFRTVENVDFSSKEGL 247 Halobacterio...
wsu_vmp:AMF_895 159 LIILNNDLTSGIPGVLDGIlTQRMIPPLHLGWFNRRKSRYFGIYSEVAEKFCTEFGIDKWGVCTLFAHCQDVDFVSRKGI 238
Q2GHY0          161 LILVNNDMTSGIPEVLQGLkYQSIMPSLFLGWFNRSKSNHFSIYKKLSKEFCESFNIDPWLISAFFSSCSNICFFNSQGI 240 Ehrlichia ch...
3K1T_A          252 EQLAEKVDSLLAKIRRKYAEYGVKQEPFVIVKADAGTYGXGIXTVKSADDVRDLNRKQRNKXSVVKEGLKVSEVILQEGV 331 Methylobacil...
WP_012823404    257 TCLQSQVQELLAEIQAKYDEHQIKEKPFVVIKADAGTYGMGVMTAQSADDVTQLNRKQRTRMSASKEGLGIDRVLIQEGV 336 Halothiobaci...
Q83AL1          255 ECLVKRAQGVLRAIKKKYDQYHIEEDPFLAVKADAGTYGMAVMMIQEAETLRHLNRKQRTRMSTSKGGVPVTKAIVQEGV 334 Coxiella bur...
Q5ZUF1          256 ETLAQEVDKILSLINDKYTTYGIENKPFAVVKADNGTYGMSVMMVHNGDEIRQLNRKQRTRMSTSKGSRKVDRVIIQEGV 335 Legionella p...
5_pfamImport    234 DALVEVVDGILANIREKYSAYGITEDPFVVIKADNGTYGMSVMMVHEGKQILQLNRKQRTRMAASKGSRKVSRVIVQEGI 313
4_pfamImport    231 DCLVANVNAVLDAIRERYAHYGIQARPFVIVKADAGTYGMGVMTAYSGEEFLELNRKARTRMAKSKEGLPVSDVFIQEGV 310
Q6MH05          239 NALAEKVDQMLARLREEYKKRGISQEPFVFVKNNAGTYGLAVIRVGSGEEVKAWSYKSRKKMKAAKGGRDVEEVIIQEGI 318 Bdellovibrio...
WP_014245543    248 DKLGSAVDDLKAELPEDKK---------IFVKASQGTYGMGISVVSSGEEIISMNRKARNKMDIGKNKIKFTSLLVQEGV 318 Halobacterio...
wsu_vmp:AMF_895 239 DDVASGVEDLISKIGEKFRFYGLDCTPHVFIKADNGTYGMGVIEVYSGEDVLNMNKKNRNKMRMIKENNPVESVVLQEGV 318
Q2GHY0          241 DDIANEVDVVISKIRNKFQLYSIKEQPYVFVKADNGTYGMGILVAYCGDDILMLNRKKRNKMKKIKDGNVVSSVIIQEGI 320 Ehrlichia ch...
3K1T_A          332 YTFEHL----KD--AVAEPVIYXXDHFVVGGFYRVHTSRGADENLNAPGXHFEPLTFETPCSTPDCAGA-PDAAPNRFYA 404 Methylobacil...
WP_012823404    337 HSFEKVsihqDDdrYVAEPVIYMVDHFVVGGFYRVHTEKGVNESLNSPGAAFVPLPFNEACSLPSPDSS-PDSERNRLYV 415 Halothiobaci...
Q83AL1          335 YTFETA----GEgnAVAEPVVYLFGRHVIGGFYRIHRGRGPNENLNSPGMDFIPMAFDFACNAPSFSDNk---SVNRFYI 407 Coxiella bur...
Q5ZUF1          336 YTFETM----PDg-SVAEPVVYMIGQFVVGGFYRVHKGRGIDENLNAPGMHFEPLAFAQACNMPCDDLEvVD-CPNRFYV 409 Legionella p...
5_pfamImport    314 YTFETM----PDg-AVAEPVVYMIGPFVVGGFYRVHHGRGKAENLNAPGMHFEPLAFAQACNMPREDLEvVD-SPNRFYV 387
4_pfamImport    311 YTYERT----AEn-AVAEPVVYLVGQQVLGGFYRVHRERGEDENLNAPGAHFEPMAFAETGVNPCRNSP-PDAPINRYYA 384
Q6MH05          319 PSIVEA----DG--ASAEPVIYMVGCELVGGFLRTHAEKSSTESLNSPGAVYKRLCVSDLAINTP--------GCPQENV 384 Bdellovibrio...
WP_014245543    319 DTIIQY----DD--MPAEIAIYLVSGKSVGGFMRANSEKKADGNLNSRGMVFRKFCISEIRQNQD--------HKAKEAV 384 Halobacterio...
wsu_vmp:AMF_895 319 PTSEVF----GT--HAAEPLLYCVGAEPVCYLCRYNSTRSRFESLNAPGCGFADVGSGI--------------AEEKKRI 378
Q2GHY0          321 TTREIF----NG--YVAEPLVYFIGHTPSCYLYRYHSVKDRFSNLNSVGCDFIDISY----------------KQQDILY 378 Ehrlichia ch...
3K1T_A          405 YGVVARLALLAATIEL 420 Methylobacillus flagellatus KT
WP_012823404    416 YGVVARLALLAAAYEY 431 Halothiobacillus neapolitanus
Q83AL1          408 YGVIARLAALATAREL 423 Coxiella burnetii
Q5ZUF1          410 YGVIARLAALAAAREI 425 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
5_pfamImport    388 YGVIARLAALAAAREI 403
4_pfamImport    385 YGVIARLAVMAAAREA 400
Q6MH05          385 YGWTAKLGLLAIAMEA 400 Bdellovibrio bacteriovorus
WP_014245543    385 YTVIARLATLASTEEI 400 Halobacteriovorax marinus
wsu_vmp:AMF_895 379 WRTVGKLAILAAAIEA 394
Q2GHY0          379 WNIIGKIAVLAAAIEM 394 Ehrlichia chaffeensis str. Arkansas
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