5NF4,4QDG,3PAY,3GF8


Conserved Protein Domain Family
Mfa2

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pfam08842: Mfa2 
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Fimbrillin-A associated anchor proteins Mfa1 and Mfa2
This family of proteins may be lipoproteins principally from bacilli. They are between 300 and 400 residues. Many Bacteroides-like bacterial species, including Porphyromonas gingivalis, the causal agent of periodontal infection, carry at least two types of fimbriae, namely FimA and Mfa1 fimbriae, following the names of their major subunit proteins. Normally, FimA fimbriae are long filaments that are easily detached from cells, whereas Mfa1 fimbriae are short filaments that are tightly bound to cells; however, in the absence of Mfa2 protein, the Mfa1 fimbriae are also very long and are not attached. Mfa2 and Mfa1 are associated with each other in whole P. gingivalis cells to the extent that Mfa2 is located on the cell surface and probably associated with Mfa1 fimbriae in such a way that it anchors the Mfa1 fimbriae to the cell surface and regulates Mfa1 filament length.
Statistics
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PSSM-Id: 400962
View PSSM: pfam08842
Aligned: 84 rows
Threshold Bit Score: 42.1303
Threshold Setting Gi: 81313705
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5NF4_B         34 PDpLQPd-----------VYLLVNar---aaHTNGee----------siNMDAEDFEDRVHSLAMLVFD-----SnTGEk 84   Porphyromonas...
Q5LAF4         24 TT-EIPete------lknISCSTQ-------LVTHss----------aqTRGAAPTTLNENDFVLYAFK-----K-NGEg 73   Bacteroides f...
EEN83395       37 TEhDDYg-----------LSAALS-------WADP------------------ADAGREIKNVRIWIFQ-----A-GGK- 73   Porphyromonas...
EDM34893       23 ME-EEPgsn------ekkVKLSFA-------VAAApele-------gqiGIAEAPLSSLIKQLTFVIYR-------DGL- 73   Pedobacter sp...
Q89YN9         29 YK-DTPk----------eGYITITg------INTRay----------tgAYPGDGLDDKVETLRILAFN-----K-TSRi 75   Bacteroides t...
WP_011965692   23 DVpSGNgdnpatgarggnMEISFL-------VPNSsngsraasaedsgvYEDGTAEEYKVSNVTLYLFD-----S-SSKn 89   Bacteroides v...
EDU99417       43 IAaQSDl----------qTRTSLPv------YDGD--------------YGNNIRGVQHVTDVYLYIYEmdkagT-DGEc 91   Bacteroides c...
Q64W13         52 SSpEVNpe---------nAAITFElsavnglTDGIgt----------rmPVYSQEATQHVTRVSVYAFV-----Q-NGSt 106  Bacteroides f...
WP_008775180   28 LS-NTPhpd------kgaVIVTTD-------WSAK---------------------STEADIPSSYMLR-------VGT- 64   Bacteroides s...
WP_005825441   42 LH-NTPhpd------kgaVRVTTD-------WTGR---------------------SEEAVQPENYLLR-------IGE- 78   Bacteroides
5NF4_B         85 VAEHFSSSIGSGTsty---------------vfTVK-LKPG-QRDFFFVA--------NI-------PNMQTAMAS---- 128  Porphyromonas...
Q5LAF4         74 NFSYEEAKHETSVidgg-------------vwkYNAaFPVG-TYKFIAFY--------NL-------DEKNQAALNttit 124  Bacteroides f...
EEN83395       74 LVAKRQYGSKFPVa------------------lDIHpLPVG-EYDVVATT--------NL-------IEPFG-------- 111  Porphyromonas...
EDM34893       74 --NTEVARQTQLSvdpl-------------fgqLSFeLPIG-EYKVVAIGska---efGI--------NKFYRNNE---- 122  Pedobacter sp...
Q89YN9         76 CESNTFYYGDVLGgn-----------------tLRHpINKG-EYDFVFLA--------N--------------------- 108  Bacteroides t...
WP_011965692   90 LVTTINVTQSDLGagtssgesskegqtivypcnKEItVKPG-NYDILAVA--------NG-------SQTFEI------- 146  Bacteroides v...
EDU99417       92 KARFNVGWREYFGannlpdk------tavmrytFAYtFTVGkTYRLVAVGvdgatgqdNMpdydgmnSKETYGLPEs--i 163  Bacteroides c...
Q64W13        107 YLHQKTYDITGWTdgttfk---------rfavpDADkLPVG-VYKFLAVGr-------DA-------TDRFSVTTP---- 158  Bacteroides f...
WP_008775180   65 --EEQSVSGITHT--------------------FKAlLPPG-GYELTAYN------------------------------ 91   Bacteroides s...
WP_005825441   79 --ESQEVTAETNT--------------------FKSlLAPG-TYRLLAYN------------------------------ 105  Bacteroides
5NF4_B        129 IVNKSDMnhfMQVFRDLDPihyhNATNNNGFPMSRMY----SNQTVTIGgtitqplPFKPDGENNVKLQRVVAKLDVnIV 204  Porphyromonas...
Q5LAF4        125 GISNQTW---ENILKSIVIthfpSATGQYHEDMNEIF----CGKTTDEIdissgigGDDNEIKIKLTLERIVSRIDI-KF 196  Bacteroides f...
EEN83395      112 AEGDETF---SSLLLKLRE---------ASTSAEHAH----YAVGHISL-------PRDRNSRIGLSLRRILSELTV-EV 167  Porphyromonas...
EDM34893      123 IPVILPF---SAANMEYWQp--nSTMGDKHYKTDDTF----FGKRSITV-------GSGTSQQVIVQLKRIVGKLEV-IV 185  Pedobacter sp...
Q89YN9        109 EPHNTIV---KAVLDNITD----YDALKSISYPAEFF-----------------------DSERVIPMIAENNSIKV-LA 157  Bacteroides t...
WP_011965692  147 GQESTLL---GQIDASTYG------NGMITSVPGSGFimsnRGSANMNItve-speESDTKTQVRINLERAVAKLMV-RN 215  Bacteroides v...
EDU99417      164 QTGSKLI---DPITLQEGK----TPTDMAHS---EFF----TGYVDKPA-------SESDKNIGEINLWRRVAGLQV-CL 221  Bacteroides c...
Q64W13        159 TSGNTNY---TDMLASIVN----------SGDESEIF----AGSADAEV-------MAQGGTRVSIEMTRKVAGVLG-YF 213  Bacteroides f...
WP_008775180   92 SPEHINV---SGNTATVVM----NKTGFAEPMPGYLF----TAHQSISV-------MADDTLKVTVPVKQLVRLLNV--- 150  Bacteroides s...
WP_005825441  106 TPEGVSV---TGNTATVDT----KDDGTLTPQPGYLF----SAGKELDV-------AADDTLKITLPMQQYIRCLTL-TL 166  Bacteroides
5NF4_B        205 EGvenlqkieLCNANVH------YRLVPNQSEPiqfYGPVELrr-vgATNQWLGYMPEai------veSTKwWGNTGNa- 270  Porphyromonas...
Q5LAF4        197 IK--------VASDDDH------IEVPYATGNIfggTGTTSLt----SLIFTSSNVPL----------KYNlNGENPD-- 246  Bacteroides f...
EEN83395      168 EGa-------PRGTRLE------TMVLNAADAL-----------------------------------VPSqKGAEGIw- 198  Porphyromonas...
EDM34893      186 ED----------VETFT------LDVDNEATGY---MFDSEKs---fGIIDNDQFQIT--------------NENGPI-- 227  Pedobacter sp...
Q89YN9        158 DGn-------LEVNG--------VASTKLTVGLr--RLAARVd----VV-------------------LKS-KVDFGDa- 195  Bacteroides t...
WP_011965692  216 DSkeiytlknPAGVTYAtvrlnnYKFINLANKFytfRHVATLdnapeTPSAPSSYSVEag-------nFGNiADNNGY-- 286  Bacteroides v...
EDU99417      222 DQ---------------------IPLEVERVRIllyNSQNTQ----------VKLLPS----------APAaSGITDY-- 258  Bacteroides c...
Q64W13        214 KNvpqv-lngSTVKYLR------LKVSNSNQQV---NLTNGVg----INTAPTPYNIIdmdlsgqavsNGVyVGNDLSgq 279  Bacteroides f...
WP_008775180  151 -E---------------------LSVTED-------DYSRALtv------------------------------------ 165  Bacteroides s...
WP_005825441  167 QLaeg---dkERIAGTA------ATLTGIAHSLdltTGEQTA------GQTGRTVAPE----------FRFgTVTPTRae 221  Bacteroides
5NF4_B        271 ----------------ENKPI-NFFRLTTRGglvy----dvpIITHEGAIPGGqyLPfAKGLLa-------------DKP 316  Porphyromonas...
Q5LAF4        247 ----------------YVTGV-QCQVTYAAP-----------SFQYGEANADA--VK-ALDYQpfpqnadainnnmeTNI 295  Bacteroides f...
EEN83395      199 ----------------GRASN-NKQPAQGKS-----------AIEQNGLIKTEt-----------------------LRP 227  Porphyromonas...
EDM34893      228 ----------------------SLYILRTDQplri----elsIGTNLSSRREL--------------------------T 255  Pedobacter sp...
Q89YN9        196 ----------------SSSEF-EGITFSNIpd--------rvPLVYGLPSDCL------------------------PSS 226  Bacteroides t...
WP_011965692  287 ----------------LIDPY-FFDKTVAGAttnf----tggSFYTNHLSKQT------------------------DSN 321  Bacteroides v...
EDU99417      259 ----------------ITSPY-GNDSFNEEGrvlmdktftkdDLYLPEPGSGV------------------------VSD 297  Bacteroides c...
Q64W13        280 gvvkvpnsqlggsfyiPVSSVsMTLGLYDASgvai----kewTVSDTNSSGATq-FNlMANHFyslgvk--gatgsvDGG 352  Bacteroides f...
WP_008775180  166 ----------------------------------------siLFTNGDTKRIE------------------------SDV 181  Bacteroides s...
WP_005825441  222 g-------------kpALAAMlRLMGVITSErqt-----ltlAVTLTDGSVQTirTD-LTEM---------------LKD 267  Bacteroides
5NF4_B        317 SYTVYRNRHY---IYRIKT--LPD---KIEVKYSIC-DWNIVTND 352  Porphyromonas gingivalis ATCC 33277
Q5LAF4        296 KKGIAKGGAY---FMGSYLlpFPSssqTLNANIQLNkANQERTIK 337  Bacteroides fragilis NCTC 9343
EEN83395      228 MPTVSHDAYA---YLRFTFrlADGslrECAAEAPIMkPAGKYTLK 269  Porphyromonas endodontalis ATCC 35406
EDM34893      256 VPIYKNKRTIvkgNLFTPI--------PHSFSVSIDdQWLPDTAV 292  Pedobacter sp. BAL39
Q89YN9        227 WAYADPVLPY-----------G-----GTAITRNVErKLTLADNA 255  Bacteroides thetaiotaomicron
WP_011965692  322 WSGLADAGKY---VSMYCL--ENCmfrPAQNTVYTT-GIMLKGTF 360  Bacteroides vulgatus
EDU99417      298 YAYKCSLTAF---MLPVNI--PDR---ELYDYTLVA-EFVTTSMT 333  Bacteroides coprocola DSM 17136
Q64W13        353 TPGNPGDDDA---PVDLLT--------DQNIVITISpAWELIHNL 386  Bacteroides fragilis
WP_008775180  182 TSMLARFNDQ---TEPIKL--------TGNLLLPVK--AGVTDAT 213  Bacteroides sp. 2_2_4
WP_005825441  268 FGGTDRKPLTldaLLNLPT--------ASSMGGTIT-GWTEVDNG 303  Bacteroides
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