Conserved Protein Domain Family
CDT1

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pfam08839: CDT1 
DNA replication factor CDT1 like
CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.
Statistics
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PSSM-Id: 400959
View PSSM: pfam08839
Aligned: 47 rows
Threshold Bit Score: 82.7566
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
PDM64591     267 LPSHYRTLHEAFKFCDQIVS--RCDGKTLTFAQ-LSIDVKRMSKKEFSVDLFSQLLAVYPQAYKVK-------------V 330 Pristionchus pa...
EFP03327     278 LPSTYEHLADSFKRVDQIAGifLGQNRTCLASE-LFKSVKSTSGREFSSYHLSQILHVYPEAFHVEm------------R 344 Caenorhabditis ...
EGT38545     275 LPSSYEHLFESFKRVDQITAifIGQNRKCLASE-VFKNVSNSSGSNFSSSHLAKILHVYPQAYHVEm------------C 341 Caenorhabditis ...
8_pfamImport   1 ---SLRLLLRLFSALEFGLGtlMLYQHTPDFAA-VKRAVESSCQLSFNPVHLQQILYLLPGAYELKwkrntctarrqaqE 76 
XP_001018111 356 LPYKYKVLLETFSKFDECIQffKDRNKPTLFKD-LKFNLEQTMRATISLKQIQQIIHLYPQAYQLK-------------- 420 Tetrahymena the...
EGF83544     310 LPSHLELLQKTFEALEKVHDftTARDQRCIYHK-IRRAVENYSNRSFELSHLAQIMYIYPEAYNLQavrtvh--dgasvS 386 Batrachochytriu...
KJE89710     529 LPAVYEKLERKFQALEDILRtrTIRDVSVSLQSlTRHMSQGDYKLSFGPEDLALIMALMPNAYSLK-------------- 594 Capsaspora owcz...
XP_002140310 242 LPTEYERLIMIFHGLEVIMRllERRQRPFLYPCfIKDQAERVIHKSIGMKDLRQISWIAPCMMSLRw------------Y 309 Cryptosporidium...
EGD74311     437 lpahcmkILRQFEQLDIIGSh-vAKKYMRTFDR-VQPGVEKMTKRSFALADLGRIMHIWPTCYKLE-------------- 500 Salpingoeca ros...
XP_003061465 111 LPPKYEVLDDAFVALAQIGPllRKRGQASTADN-VCENVEATTRRRCTLKTLREVEGVLPGTVGLS-------------- 175 Micromonas pusi...
PDM64591     331 KQLTCVgDRMGGARaaRWEHVIK------P--NLdDDLTsfvtaplpseqplpsepllttsprknlfspmkgrpvtsssg 402 Pristionchus pa...
EFP03327     345 EQRKAF-GQGGK-----YELEIR------P--NLiDDLRgyilektpvedndelplv------------------cpskl 392 Caenorhabditis ...
EGT38545     342 EQRRAF-GQGGK-----YELELR------P--NLvDDLRgyirettpvendeelplv------------------cptkl 389 Caenorhabditis ...
8_pfamImport  77 EGGDSLlAQHQRLQhqKPVLTLRkqqlppP-------------------------------------------------- 106
XP_001018111 421 -------WVQNKQAheQLDLLVN--------------------------------------------------------- 436 Tetrahymena the...
EGF83544     387 SILIESsKASHDANqsIFEALVQ------PskNIaNSMHlppciqgkqqen----------------------------- 431 Batrachochytriu...
KJE89710     595 -VLKSDaHKLHNWAdsQYQLHVRf-----P--------Aa---------------------------------------- 620 Capsaspora owcz...
XP_002140310 310 RINENSrIISDDSSqsCYQIELV------PcnGInNPIs----------------------------------------- 342 Cryptosporidium...
EGD74311     501 ----QVlIKDAQRGtgEYKLKMT------P--LMpSAD------------------------------------------ 526 Salpingoeca ros...
XP_003061465 176 --TRAPvHDGGALDprRVRVDVEeg---aPga------------------------------------------------ 202 Micromonas pusi...
PDM64591     403 iripasprkpsspVkpfmREVMMdtrkRFEGWRRNCRQQVFRCLLSRRVISAHEKFI---EGLNLD-----------PSl 468 Pristionchus pa...
EFP03327     393 lspkksprkkvqpVarqpD---IdgkiRLDAARQRDRAHIFRHKLTTIVMKHHEEFL---ESQG---------------- 450 Caenorhabditis ...
EGT38545     390 lspkksprkqvqvVprqpQ---LdgriRLDAARQRDRGHILRHKLTTIVMEHHEAFL---ETQG---------------- 447 Caenorhabditis ...
8_pfamImport 107 ---------------------------NTDCESLQARIALFVRKV--------NAFL---EGHVNA-----------IQn 137
XP_001018111 437 --------------------SACdendNRVVLTKADRLQKLRNLLVEKVKYFHNLYL---KSQA-------------REh 480 Tetrahymena the...
EGF83544     432 -tplsvsrrticpEtrsiDDFSThkrlIMAASMLESRLLTFRRRLEDWVDTTHNAFL----DADPR-----------RKi 495 Batrachochytriu...
KJE89710     621 -------------PgvpsTEWAGekssIMSDTTKLQRMDAFHQNLRKLAWTTYDTKL---RHLLGY-------------- 670 Capsaspora owcz...
XP_002140310 343 ---------------------------RLSQVTINERVNKFRLTLIQWVLYQHDEYLynnKAIKVP-------------- 381 Cryptosporidium...
EGD74311     527 --------------------GDTehrrYLSVAEIHDRVSTFHMRLLNYVHTHHEKHL---ATLPGK-----------PS- 571 Salpingoeca ros...
XP_003061465 203 ----------------raPGAGAgasrKTGSGWFDDRRKKFRAALLELVGAHHDAFV---AGLDDDgggggggggggVE- 262 Micromonas pusi...
PDM64591     469 vPPSsSFLPRiFHDDFtrKIDSiCSPIEKAEI 500 Pristionchus pacificus
EFP03327     451 -FLSvSGIKR-MHPLF--RLDVhCPKLPQVKL 478 Caenorhabditis remanei
EGT38545     448 -LTGmKGMKR-VHPLF--RPDKhCPDLPQMPL 475 Caenorhabditis brenneri
8_pfamImport 138 eFPDmTDD----------EIKNaLKLVEIEKA 159
XP_001018111 481 lEQElLDNFR-WHDDF--KLQD-VPNLEEQAL 508 Tetrahymena thermophila SB210
EGF83544     496 eMEGlCGIPQ-WHSQF--DLST-VPELPMAAL 523 Batrachochytrium dendrobatidis JAM81
KJE89710     671 -SSDiKFAGT-LHHAI--PWDTlPLDIEPITL 698 Capsaspora owczarzaki ATCC 30864
XP_002140310 382 -IFPlEKLDH-WSFEF--DNKT-CIPIPEIKM 408 Cryptosporidium muris RN66
EGD74311     572 -VPL-AKLQR-WHSGF--QVEQ-VPAIPVGEV 597 Salpingoeca rosetta
XP_003061465 263 -VDDdGVVTS-WHPKY--DPTT-APDppaarv 289 Micromonas pusilla CCMP1545
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