Conserved Protein Domain Family
MHCassoc_trimer
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pfam08831: MHCassoc_trimer 
Class II MHC-associated invariant chain trimerisation domain
The class II associated invariant chain peptide is required for folding and localisation of MHC class II heterodimers. This domain is involved in trimerisation of the ectoderm and interferes with DM/class II binding. The trimeric protein forms a cylindrical shape which is thought to be important for interactions between the invariant chain and class II molecules.
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Statistics
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PSSM-Id: 489923
Aligned: 9 rows
Threshold Bit Score: 101.403
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001184039 125 NKVEDAAKYMLLRGNPLRKYTLPNGTILENLRELKKSLTDQEWMNFDAWMHQWYLFFLVQNTGKAaEPLP 194
XP_008103026 112 NSTEDQVKRVLLRENPLRKFPEFNSSFIENIGQMRFRMDYEDWKAFETWMHKWLLFQMAQNAIPE-EKVK 180
2_pfamImport   1 NKTEDQVRHLLLQADPKKMFPELKDSLLGNLKSLKKTMTDADWKSFESWMHKWLLFEMAKSPKPD-ERKA 69 
ELK17270     120 NSTLDHVMHLLLKSDPLKVYPQLKGSFPENLKRLRNTMEGLDWKAFENWMHQWLLFEMSKNSLEE-KPKP 188
EHB16002     121 NMTQDHVMHMLLKSDPLKVYPQLEGSFLDNLKHLKNTMESLDWKVFESWMHHWLLFEMSRNSPGE-KPTE 189
Q29630       118 NMTQDHVMHLLLKADPLKVYPQLKGSLPENLKHLKDSMDGLDWKLFESWLHQWLLFEMSKNSLEE-KPFE 186 cattle
P04441       119 NMTQDHVMHLLTRSGPLE-YPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEkKPTE 187 house mouse
XP_007473939 116 NSTTDQVKYLLQRSDPRRSFPDLTKSFQENLKHLKSNMDPKNWKTFENWMHQWLLFEMSKKPKEE-KTET 184
XP_007653534 117 NSTTDQVMHLLLKGAPTKIYPELNEGFQDNMEQLKNNMGHESWQNFKHWMHHWLLFELSKKPQNA-TPTE 185 platypus
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