1YOV


Conserved Protein Domain Family
E2_bind

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pfam08825: E2_bind (This model is not part of the current CDD release)
E2 binding domain
E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades. This is an E2 binding domain that is found on NEDD8 activating E1 enzyme. The domain resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.
Statistics
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PSSM-Id: 518526
Aligned: 123 rows
Threshold Bit Score: 60.98
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YOV_B        357 FSPSAKLQEVLDYLTNSASLQMKSPAITatleGKNRTLYLQSVTSIEERTRPNLSKTLKELg--------lVDGQELAVA 428 human
15_pfamImport   2 LDTSITLQKFIDMLEEHPKLLLSKASVK----HGKDSLYMQAPPVLEEMHRPNLSKPLYDLmgrvqketvhVFGT-ALKN 76 
Q22T77        347 ISRSTKLQELQDLLKEKPF-ELTDPSL------TADNGSMLIPVVMRNQHAEKLPMSFTQLiae----ghyQEGLIIHVT 415 Tetrahymena th...
XP_004031048  361 ISKNMLLKDFQKLLQSKPY-EFLDPSL------TGQDGRLIIPVVMRDLHKEKLEMTFDQLaqq----niyKEGEIIYIT 429
14_pfamImport   2 DADSMTLQNLIDHLC-GDNFWLSKPSIs----sGSANLFMQGPPSLRAATSPNLDKTLRELv---------KDGESLTIT 67 
XP_067746238  376 DPDAVTLQQLIDQLC-GDDFRLLKPSIs----sSNVNLFMQGPPALRAATSPNLAKSLRELv---------KDGESLTVT 441
XP_002291992  397 LQGSTTLNALLQKLC-DGELRLKSPSVt----sSTKTLYMRKPVALEKATRQNLDKPLKELf---------SSGEELTIT 462
O65041        350 LDTSVTLSKFIEMLEDHPKLLLSKASVK----QGENTLYMQAPPVLEEFHRPKLSKPLYDLmgrvqkdtihVFGQRALKN 425 thale cress
XP_018636318  493 DPDETSLQDLLELLSQDPALNLKGPGIs----sATAVLFLQKPPQLRQQLETNLRKSLRELads----gmlKEGEELLVT 564 Toxoplasma gon...
XP_655964     339 IPTTFTLQQLVDEISDDPELQVSNPSIG----LESGQIIFVSRGPLKEQTEKNLVLELCQLg--------vKEGEELIIN 406 Entamoeba hist...
1YOV_B        429 DVTTPqtVLFKLHF 442 human
15_pfamImport  77 EEKQSrlAKLRVVF 90 
Q22T77        416 DKKLFapAKIQIHF 429 Tetrahymena thermophila SB210
XP_004031048  430 DQKIHsvAKVIVSF 443
14_pfamImport  68 DAVFVgdMALSLQI 81 
XP_067746238  442 DAAFVgdMALSLQI 455
XP_002291992  463 DPVFHd-TSLSVIV 475
O65041        426 NEKESctTKVRVVF 439 thale cress
XP_018636318  565 DVALPstLRLRLFF 578 Toxoplasma gondii ME49
XP_655964     407 SPAISspIFLKIHY 420 Entamoeba histolytica HM-1:IMSS
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