2A4H,2A2P


Conserved Protein Domain Family
Sep15_SelM

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pfam08806: Sep15_SelM (This model is not part of the current CDD release)
Sep15/SelM redox domain
Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. Structurally it resembles the thioredoxin-fold.
Statistics
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PSSM-Id: 518517
Aligned: 33 rows
Threshold Bit Score: 73.3595
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2A4H_A        22 KAILEVCTCKFRAYPQIQAFIQSGR--PaKFPNLQIKYVRGLDPVVKLL---DA-SGKVQETLSITKWNTDTVEEFFETH 95  fruit fly
XP_001600851  33 AVVESCRGCQLNRLPDVKAFILEDV--P-LYDNAEFKHIQGAPPELVLY---DH-AEKEIERLQIGLLTREECNELMYEK 105
XP_032514113  29 ARIETCRGCSLNRLPEVKRFVMDDA--P-HFERLEVKFITGAPPELILL---GN-GDKELERIPLSNLSRQECNDLVKSK 101
Q8VHC3        40 GRVETCGGUQLNRLKEVKAFVTEDI--Q-LYHNLVMKHLPGADPELVLL---SR-NYQELERIPLSQMTRDEINALVQEL 112 house mouse
7_pfamImport   1 ARVERCAGKSLNRLKEVKAFVTQDI--P-LYHNLAMRHAGVAGPPLGGAggpDS-ALLRLQRIPLSDMTREEINALVQEL 76 
XP_015838752  31 ARVESCPSCKLNRLPEVKAFIYEDL--P-KYDNTEFKKIQGAPPVLLFL---ND-ADEIVEQHSLEKFSRQECNNLLKSK 103
XP_002958918  31 AEFISCPGURLNHLPEVKRFLKGDIeqG-AYENVAVNFIPGRIPELVLY---DS-NNVEVERMFVDKLKYDELHTLIQTK 105
3_pfamImport   1 GHIVSCSGUKLNKLPEAKKFLKNPEhaA-SYEDIEVEFKAGKPPVLTLF---DKaSGEETESINLEKFTIDEMHELLVSR 76 
2A2P_A        17 GRVETCGGCQLNRLKEVKAFVTEDI--Q-LYHNLVMKHLPGADPELVLL---SR-NYQELERIPLSQMTRDEINALVQEL 89  house mouse
Q8WWX9        40 arvetcgguqlnrlkEVKAFVTQDI--P-FYHNLVMKHLPGADPELVLL---GR-RYEELERIPLSEMTREEINALVQEL 112 human
2A4H_A        96 L 96  fruit fly
XP_001600851 106 G 106
XP_032514113 102 G 102
Q8VHC3       113 G 113 house mouse
7_pfamImport  77 G 77 
XP_015838752 104 G 104
XP_002958918 106 G 106
3_pfamImport  77 G 77 
2A2P_A        90 G 90  house mouse
Q8WWX9       113 G 113 human
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