4Q9T,5IJN


Conserved Protein Domain Family
Nucleoporin_N

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pfam08801: Nucleoporin_N 
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Nup133 N terminal like
Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.
Statistics
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PSSM-Id: 400932
View PSSM: pfam08801
Aligned: 51 rows
Threshold Bit Score: 172.574
Threshold Setting Gi: 123478393
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4Q9T_A            16 TETEKYSVTKLsTDLSFLPGSNGNNntidtHHFEGLVDTALQKALVNDLDHIYIWNYNSIqkdtpICKISLH-DDYSVLS 94   Vanderwalt...
Q9V463            66 NLQQMRTVTKS-AIPNEILEHFKHIk----CHCTMGLFPEIGRAWLTIDSEIYIWTFNQTr-----DVAYYDgLSHLIVS 135  fruit fly
Q17JY3            67 NLNQLATVNKI-PIPPEIMEHFKHIk----CHCMMGLFPEIGRAWLTIDSDIYIWTYEHTr-----DVAYFDgLSHLIVS 136  yellow fev...
F4HXV6            53 EWPPLIEVGETwELPSVLIERYNTAgg--eGTALCGIFPEIRRAWASVDNSLFLWRFDKRd----GQCPEYSgEEQAICA 126  thale cress
jgi:OSTLU_17095   52 WPSDVVGMKKE-ELPGVVLERYNTRq----SVCFCGVLPEISRAWASVDNALFLWRLDVAd----DVPVEYSgEEQAIVA 122  Ostreococc...
CAM44479          56 AVPDFFPVGGV-AWPEPLLELWKSMr----YSSLTGVFADLSRAWFTVDNRLVIWDYHGGr-----EFCIYDeIPELISV 125  Leishmania...
Q38AE7            59 TLPAFLPLTGV-TWPEAVKAVWKTFr----ANSTVGLFPELSRAWITIDNKLLLWNFGTGr-----DFFLFDeVPELIVA 128  Trypanosom...
Q4E149            59 TLPDFIPLVGV-SWPEPVKAVWKTFr----ANSIVGLFPELSRAWITVDNKLLLWNYGTGr-----DFLVYDeIPELIVA 128  Trypanosom...
XP_001322359      51 KRRDIATITSIsPYPSEVANC---------GSGKLGYLSEINKYYLINSQKIYLW--TPLk----SDTQIVQeDGYDILA 115  Trichomona...
XP_317470         67 DLNQLCTVNKV-PIPSEIMEHFNHIk----CHCMMGLFPEIGRAWLTIDTDLYIWTYENAr-----DVAYFDgLSQVIIS 136  Anopheles ...
4Q9T_A            95 SPpiclFTSSISSTNNdtanynnnasgninsgkfNNGICIINKKNSQFLYFEDISTInnl---------ytkLSKSKAHV 165  Vanderwalt...
Q9V463           136 VG----LVKPKPGVFVq-----------------DVKYLLVLTTPIEVIVLGVTFGEs-------------sYNEMQLMN 181  fruit fly
Q17JY3           137 VG----LVVPKPGVFIs-----------------DVKYLLVLTTPIEIVILGVTFGDsnaspn---rsitssIEEMQLLN 192  yellow fev...
F4HXV6           127 VG----LAKCRPGVFVe-----------------AIQYLLVLATPVELVLVGVCCTEgpdg-------rdpyAEISVQPL 178  thale cress
jgi:OSTLU_17095  123 VG----LVKPKSGVFLe-----------------AISYVLVIATTVELVMVGVCLEDd--------------GRELTLHP 167  Ostreococc...
CAM44479         126 VGa---PLRPLSGVFQp-----------------HVTYIIPVGTTSMMFLLGLCIMGeg------------aQAEMKVVN 173  Leishmania...
Q38AE7           129 VGt---PVLPIAGVFQa-----------------HITYVLPVSTPKAVHLLGLCVFGggp----------lkKAELYVVS 178  Trypanosom...
Q4E149           129 VGn---PVTPVAGVFQp-----------------HITLVFPVATPKTIHLLGLCVVGdet----------akKAELCVVN 178  Trypanosom...
XP_001322359     116 VA----IMEPDYDLISd-----------------KVSNFLAISTHSYIKLYPIMDSKi-------------iTDRFYHIE 161  Trichomona...
XP_317470        137 VG----LVTPKPGLFVa-----------------DVKYLLILTTPIEIVVLGVTFGDansgtpnrsmtasqgTEEMQLMH 195  Anopheles ...
4Q9T_A           166 LDLKLKDN-ENITSTINCEPSG-IIIATSLGRVLFITIKDSTGk---PKLELKQqlIKPQNSFF-----------FRNLD 229  Vanderwalt...
Q9V463           182 RPVFVIGTdNVSISVIKGTDDGrIFLGGRDGCLYEIYYQAESSw---FGKRCKK--INLSQGLVsy--------mVPSFL 248  fruit fly
Q17JY3           193 KPIFVLNTdNVAITCIEGTSDGrIFLGGRDGCLYEISYQAESNw---FGKRCKK--VNHSQGLMsh--------lVPGIF 259  yellow fev...
F4HXV6           179 PDYTISSDg-VTMTCVTCTNKGrIFMAGRDGHIYELLYTTGSGw----NKRCRK--VCLTAGVGsmis----rwvVPNVF 247  thale cress
jgi:OSTLU_17095  168 LQYSCPTDaTIMND-ITSTPEGrIFLAGADEALYELVYAQSDTw---HSKRCKK--VRHSQNLSs---------lLPSVL 232  Ostreococc...
CAM44479         174 LGYSCSTD-TVITKAIGSG--GhVFCAGADGNVYEVRYMRDNTp---ITPKIRM--VSYGYWLStapvlgqvtsvVASVW 245  Leishmania...
Q38AE7           179 LGFSVMAP-ALFTKLVGVKELGrIFAAGADGCLYEVKYAKEDTa---FLPKLRL--VNCSLMFGsvpvlgavsslISAIK 252  Trypanosom...
Q4E149           179 LGFSVLAP-TLFIKLVGLRDLGrVFAVGADGCLYELKYTKESTp---FIPKVRL--INHSIIFAgipilstvsslMSTLK 252  Trypanosom...
XP_001322359     162 TNFTPF--------SLVGGPDNcLYAGSQLGDIHIIEIVSKQDflsrCLGSLPK--NINPFTMLdpevvptikngTASLF 231  Trichomona...
XP_317470        196 TPIFVLNTdNVAIMCVQGTEDGrIFLGGRDGCLYEVAYQAESNw---FGKRCRK--INHSQGLMsh--------lVPGIF 262  Anopheles ...
4Q9T_A           230 S----------SKEIISLKKGPIVgkgeRLLYITTRGGSLQIWQLSin---sKSFKRLEINIYEHVLDSl-----QDLy- 290  Vanderwalt...
Q9V463           249 Kvf------seVDPIEHIEIDNSR----KLLYVLTEKGVIEAWDISts--ytTARRLGRITQNDITNQAvs---lITT-- 311  fruit fly
Q17JY3           260 Kvf------seNDSISKITIDNSR----RLLYALTEKGAIEAWDIGsd--anSVRRIARISQNDIASSAgn---iLRTie 324  yellow fev...
F4HXV6           248 Kfg-------aVDPVVEMVVDNER----QILYARTEEMKLQAY-VSgp--ngEGPLKKVAEERNLLNQKdlsqgnRQSav 313  thale cress
jgi:OSTLU_17095  233 Rlk-------gSDALKQVVVDAKR----GILYTRSEQGVVVVYDVGaaakdaPRKVAEVKNVAQLAAQArgqgslFASat 301  Ostreococc...
CAM44479         246 Kswr----ggmHGGLIDLVVDERD----GILATLCERSRISLWRLIps---gGMRYILSLRHRPGRLPR-------SHt- 306  Leishmania...
Q38AE7           253 Qtwa-----keRPALRDVAIEAKR----KLLFTLNSESTISLWRIT------NDGLSQLATVRGGALgg-----tNRTsv 312  Trypanosom...
Q4E149           253 Qtwa-----kqRPALRDIAAESKR----KLLFTLDAEGKILMWRITee---gLKVLTTVKCTRSSFEhhr---hlESSa- 316  Trypanosom...
XP_001322359     232 SeitpefirfrDHALIKLAYDPTT----KYLAAIDEDSNIFFYK---------------CSRRHLFHVG----------- 281  Trichomona...
XP_317470        263 Kif------teTDSVEKIVVDNTR----NLLYVLMSKGSIEAWDIGkd--agSTRRIARLSYKDIIASAsa---iLRT-- 325  Anopheles ...
4Q9T_A           291 PFAHGTLAFLDSHPIYSDTSSAHLTLASISNGNeiYYLXITV-------------------------------ILDEKtN 339  Vanderwalt...
Q9V463           312 VDPSIFKSVKAICPLSADDADKLHLVAVTQCGVrlFFSTTSLnvkqqfgpavpcspgentgfgqpavqpplspNAEAPkG 391  fruit fly
Q17JY3           325 PSVFK--PVTALCPLSLEDSPQVHLIAITQTGVrfYFSTVPV-------------------------------LFSIQqQ 371  yellow fev...
F4HXV6           314 AGRSNKPSIVSISPLSMLESKWLHLVAALSDGRrmYLSTSSSgsgstis------------------fsgfnnHRQTPnC 375  thale cress
jgi:OSTLU_17095  302 SSVKKGAKLVHVALVHPEESSVVTLVAICADGRriYLTALPPsrgysyg-----------------vasgtgsSRQGPsR 364  Ostreococc...
CAM44479         307 TPNGEPAPLVRLFVIETD-AQGCRLMATALNGDqfRYRYINI--------------------------------FDSVfS 353  Leishmania...
Q38AE7           313 WSGGAGVELARIFCATSS-DDSCSLIAVAANGEqyRYVCQDG-------------------------------LWGGAd- 359  Trypanosom...
Q4E149           317 DDATSFVKIFCVSPYDEN----FSVVVITSNGEqyRYLCQEG-------------------------------MWDRTdG 361  Trypanosom...
XP_001322359     282 SHYSGDVPIVDISYVPNSDSRLIRFVGFDQQGNrlYFGFSEK-------------------------------LLGVSsS 330  Trichomona...
XP_317470        326 IDPSVFHPITAICPLTAEDSSSLHLVAIAESGVrfYFSTVPLh------------------------------LHGKPqG 375  Anopheles ...
4Q9T_A           340 --------SFQIFSIykl--------ntYFTKSTVDLn------hKPQLFIPNalds----ivsPTLSVYVLFN------ 387  Vanderwalt...
Q9V463           392 ly-----lLHVRLPPg------------YTPNATTNK--------PKQVHAAHy---------tEGTMLMITTQq----- 432  fruit fly
Q17JY3           372 qlhqqqqqQQQQQPGlstfdhqqrpqglYLLHVRLPPgy----tpNTTVGKPKqvhs---afysQGSLLMVSTPq----- 439  yellow fev...
F4HXV6           376 lk-----vVSTRPSPplgvg----vglgFGAASVAGRtqnddlsmKIETAYYSvgtlvlsdsspPAMSSLLVVS------ 440  thale cress
jgi:OSTLU_17095  365 ls-----vVEQRDPPpqggn---qrgmtTAQALLNTT---------SRALEIEagf------ysSGVLLLSDATpn---d 418  Ostreococc...
CAM44479         354 ae-----lILQSHTPs------------YLSVNKEIS-----------VCYAS-----------ASAFLAAFSDmnd-dr 393  Leishmania...
Q38AE7           360 --------ASLSLREsl---------gsYIPQGREVT-----------VCFAS-----------EGISVVCHAEkseggy 400  Trypanosom...
Q4E149           362 n------lTLRDWTP---------------SCIPSNR--------EVSVCFTS-----------DGVALFCHTEkddena 401  Trypanosom...
XP_001322359     331 it-----lQALRKPP----------------PEYEGK----------KLLSGAy---------sLGFCALVYNEgvf--v 368  Trichomona...
XP_317470        376 ly-----lLHVRVPPg------------TTGNLLLTK---------PKLVHSAhy--------vKGSLLLISRQq----- 416  Anopheles ...
4Q9T_A           388 -NAVVXTQI--------------------------SSKLDSSFPLRR----KWEDI--IRFNK--DVEIIG--------- 423  Vanderwalt...
Q9V463           433 hEQDLLWSLssaps----------------vnftyLVESTALESLDGv---VWGLA--EVHEPstPQRKSP--------- 482  fruit fly
Q17JY3           440 pDQDLLWSLssepf----------------psrqnLVESSTVMTMDGq---VWA----IAEVKpkDKVTVD--------- 487  yellow fev...
F4HXV6           441 -RDSSVHSQagsssgp------------ssrssraLREVVSSLPIEG----RMLFVadVLPSPdtAATIQSlyseleycg 503  thale cress
jgi:OSTLU_17095  419 sDARLILSNrdlalpphlqlppptpppssgsgtrgLREVVTLEQLEGrcasSLGSLgeIPMPKsvQDAIDPpyptgtlpe 498  Ostreococc...
CAM44479         394 aSDEVLAATspatvi---------------aphqnVRDIVATFSGSSs---RIVRVdaIERMPtqGSQNFS--------- 446  Leishmania...
Q38AE7           401 sPDSVTVASshkgil---------------qphhnCRDIVAQFEPEAt---CMTRVdaISEVPveGGVSPN--------- 453  Trypanosom...
Q4E149           402 sSDSVAVTTspktvl---------------pphhhCRDIVAHFEPSAs---LMARVdaIGEVPvrESVSPN--------- 454  Trypanosom...
XP_001322359     369 tKSTILMRP--------------------------SEEFNSFVVPCS-----GAHV--FSLRHnlDYLSPQ--------- 406  Trichomona...
XP_317470        417 qDQDMLTCLsseqf----------------qsqlnLVESTTYMPLDGq---VWAIA--DVLRKdrVSISTP--------- 466  Anopheles ...
4Q9T_A           424 -----SGYSTDSI------------------YVICKDXGVLK 442  Vanderwaltozyma polyspora DSM 70294
Q9V463           483 -----LNSARHARk-----------------VALLTNQGTHI 502  fruit fly
Q17JY3           488 -----TPLRAAqvp---------------kkVALLTNQGVHI 509  yellow fever mosquito
F4HXV6           504 vevsgESYEKACGklwarsdlstqhilprrkIVVFTTMGMME 545  thale cress
jgi:OSTLU_17095  499 arvksTGLLSELVtqymc---------prrtFVLMTNAGLVR 531  Ostreococcus lucimarinus CCE9901
CAM44479         447 -----DLCAQVcsp--------------gptYVVVHRHGLSL 469  Leishmania braziliensis MHOM/BR/75/M2904
Q38AE7           454 -----ELCSQVScsp--------------rqFVFLHRHGVST 476  Trypanosoma brucei
Q4E149           455 -----ELCSQVVcsp--------------rqFVFVHRHGIST 477  Trypanosoma cruzi
XP_001322359     407 -----PVFTDAELwqhvi---------pappFLLCSLDGTAE 434  Trichomonas vaginalis G3
XP_317470        467 -----LRTAqnp-----------------rkVALLTNQGVHI 486  Anopheles gambiae str. PEST
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