1RW2


Conserved Protein Domain Family
Ku_PK_bind

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pfam08785: Ku_PK_bind 
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Ku C terminal domain like
The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.
Statistics
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PSSM-Id: 400921
View PSSM: pfam08785
Aligned: 98 rows
Threshold Bit Score: 80.315
Threshold Setting Gi: 388581870
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RW2_A        35 NPAENFRVLVKQKKA-----SFEEAS-NQLINHIEQFLDTNETP-YFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEK 107 human
XP_002405506 551 NPVEDFKKLLADKDH-----RFDDVC-SQLEGVILKLFDDTLGRaVYAKAVRCLRAYREASLEKSDPGKFNDFMNKLKSL 624 black-legged tick
XP_009028666  71 NPVEDFHELILHDSn-----LFQTAC-EQLQSQIEQLIVDSFGSdLYNKAVNCITALRVQCIKNLSAEKYNNFLKSLKKF 144 Helobdella robusta
XP_001861497 584 TPAEDFALLLKRGEK------FATVC-TQIQNVISGLVFKSMTT-QYEKVAMAIMIFREEA-KLLGPYRFNEWIGEFKKS 654 southern house ...
ETN65831     588 TPAEDFDLLLRRGEK------FVTVA-NQMQTVIFELLFTSMHT-PVEKVIMALMMYRGEA-QKLGPFRYNEWMTEFKQV 658 Anopheles darlingi
Q7Q190       540 TPAEDFALLLRRGEK------FATVA-TQLQNAVFELLFTSMRP-PGSKVIAALLAYRSEA-QKLGPYRYNEWMTEFKEM 610 Anopheles gambi...
XP_002897431 618 NPIADFEALIESSQSklsrrQQLTTAvTGMETQIEKLLSQSGSE-FFPKAMQCLSHFRKRSPEIQYSTQFNEFLTKLKTV 696 Phytophthora in...
3_pfamImport   1 NPIADFETLIESSRLktnrrHLLTTAvAGMQMQIEKLLTQSGSA-SFTKALQCLTHFRNRSPEIQYSAQFNDFLTKLKSV 79 
XP_001944675 529 SPIEDFNKLLENGFNsa------iVC-GKMKNITLDLIESSTSMkDLEKPASNLKALREFYIHDNDVKSYNNLMYLVKDS 601 pea aphid
1_pfamImport   1 TPIEDFKKFLKNGFDsa------iAC-GLLKVVTKMLIRDSKSLeDLMKPIAALQALREYYIINNDAKSYNNFMYSAKRT 73 
1RW2_A       108 VE--IKQLNHFW-EIVVQDGITLITKEEASGSSVTAEEAKKFLA 148 human
XP_002405506 625 YS---IKREELWeLLIKEA-VQPVGKAECSKSALEDDEVERFYV 664 black-legged tick
XP_009028666 145 II--DKQRVNFW-SEIKTSNLGLIKSTECESSSVDDAKAEEFLM 185 Helobdella robusta
XP_001861497 655 LLs--RNKQEFWqRVVVQERFGLIGAAESEMSTITANEVEEFYD 696 southern house mosquito
ETN65831     659 LLg--RSKHEFWeQVIVREKLGLIDVSESDMSTVSVDDAIEFYR 700 Anopheles darlingi
Q7Q190       611 LLt--RQKADFWeTVIVGEKLGLIDSQESEMSTVSVDQAANFYK 652 Anopheles gambiae str. PEST
XP_002897431 697 LSedS----EAWkTVKDAD-IGLISSTEDPSVDVSPAEARAFLH 735 Phytophthora infestans T30-4
3_pfamImport  80 LSedS----DAWnAIKDAN-VSLLTSAEDPVVDVSPAEGCAFLH 118
XP_001944675 602 VLl--SGKEEMWsQFIDSG-IGLITNQEVEISDITQELSENFMK 642 pea aphid
1_pfamImport  74 LCm--SGKENMWsKFINSG-IGLITNVEMEGSDISREEAEEF-- 112
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