5C4V


Conserved Protein Domain Family
c-SKI_SMAD_bind

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pfam08782: c-SKI_SMAD_bind 
c-SKI Smad4 binding domain
c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4
Statistics
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PSSM-Id: 400918
View PSSM: pfam08782
Aligned: 33 rows
Threshold Bit Score: 124.28
Threshold Setting Gi: 196009123
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5C4V_B                26 FEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNqk--ylG-T 102 
ETN64852             289 FRVYHRCFGKCEGILTPELYSYEEPACIECCECRGLYSPQKFVCHQHEPQEIRTCHWGFDSSQWRLYIHVId-----S-D 362  Anophe...
WGS:AANI:GJ24706-PB  201 FQVYHKCFGKCEGICTPDMYSYQKPTCIQCLECNCWFSPQKFVGHVHRKVENRTCHWGFDSRNWHDYLHVAl-----D-V 274  Drosop...
1_pfamImport           2 FKVYHKCFGKCEGICTPQMYSFGNPACIECVECKAMFSPQMFVGHAHGKPENRTCHWGFNSRNWRDYLHVAl-----DiV 76  
EEN43401             200 FKVYHECFGKCKGVFCPDLYESPFSQCIECTDCHGAFSPQKFVCHSHKAQENRTCHWGFDSANWRSYILLSk-------d 272  Florid...
XP_007237004         223 IKVYHECFGRCAGVLLPELYTSPSAPCIRCAHCGLLLAPRRFVAHAHGTPENRTCHWGFDSDNWRAYVLLRas---eY-A 298  Mexica...
EFX79843             157 FRVYHQCFGKCEGLCKPELYTSPDAMCIECADCSLTLSPADFISHAHRSVENRTCHWGFDSTNWRAYLLLArrq-qqP-Q 234  common...
3_pfamImport           1 FTVYHECFGKCRGLCLPELYTDCEARCIECLECHGLLSPRQFVCHSHRSPENRTCHWGFDSDNWRAYLLLCr------dQ 74  
XP_015782317         388 ipICHECFGSCSGTVYTDLYIEPTSRCIKCSECKMWLTPQRFVTHIHSSSENHTCHWGFDSYNWRAYIHLDeeskeyQ-L 466  two-sp...
XP_030842749         239 MKVYHECFGKCKGLLTPELYETANSSCIECLECSVMLTPQKFIVHGHKRRETRTCHWGFDSDNWRNYLLLAs------dQ 312  purple...
5C4V_B               103 PEEKKLKIILEEMKE 117 
ETN64852             363 KNRDEHTQILQKIWN 377  Anopheles darlingi
WGS:AANI:GJ24706-PB  275 ENREKYQRILDQLKE 289  Drosophila virilis
1_pfamImport          77 DKREIYNEMLDNLKA 91  
EEN43401             273 QDTEEFQEALEDMKA 287  Florida lancelet
XP_007237004         299 GRSKRRRQRKGERED 313  Mexican tetra
EFX79843             235 PSNEVLLHQLDEFKN 249  common water flea
3_pfamImport          75 PDLETREKLLDLFKQ 89  
XP_015782317         467 ADVEQLEAELDSFKS 481  two-spotted spider mite
XP_030842749         313 NPEEKYKEALDNVKA 327  purple sea urchin
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