5C4V


Conserved Protein Domain Family
c-SKI_SMAD_bind

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pfam08782: c-SKI_SMAD_bind (This model is not part of the current CDD release)
c-SKI Smad4 binding domain
c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins. This domain binds to Smad4
Statistics
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PSSM-Id: 518501
Aligned: 23 rows
Threshold Bit Score: 121.641
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5C4V_B                25 AFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSP-DKRTCHWGFESAK---WHCYLHVNQKyl 100  human
6_pfamImport           1 GIPICHECFGSCSGTVYTDLYIEPTSRCIKCSECKMWLTPQRFVTHIHSSS-ENHTCHWGFDSYN---WRAYIHLDEEsk 76  
1_pfamImport           1 SFEVFHDVFGKTRGVCMPELYTEKFSACIQCVECKALFAPQRFVNHIHRFT-GTNSCHWGYKREN---WKAYVKVSh--- 73  
ETN64852             288 AFRVYHRCFGKCEGILTPELYSYEEPACIECCECRGLYSPQKFVCHQHEPQ-EIRTCHWGFDSSQ---WRLYIHVId--- 360 
WGS:AANI:GJ24706-PB  200 SFQVYHKCFGKCEGICTPDMYSYQKPTCIQCLECNCWFSPQKFVGHVHRKV-ENRTCHWGFDSRN---WHDYLHVAl--- 272 
4_pfamImport           1 SFKVYHKCFGKCEGICTPQMYSFGNPACIECVECKAMFSPQMFVGHAHGKP-ENRTCHWGFNSRN---WRDYLHVAld-- 74  
XP_009025482         113 TFRVQHDCGWGCRGAFVPSRYNSSRAKCIKCLICDVYFSPNKFIFHFHKSi-NSKYNH--PDAANfnsWRRHMKLIDE-- 187 
EFX81507             105 AFDVSHCCAWGCRGAFLPSRYNSSRAKCIKCFYCSLFFSPNKFIFHSHRSLpDAKYIQ--PDAANfnsWRRHIHLTGS-- 180 
XP_009018725         139 AFQVYHTCGWGCKGCFMPSRYNSSRAKCIKCSYCNLILSPNKFIFHFHRMp-NSKYHH--PDAANfnsWRRHLFLDYE-- 213 
XP_008204568         264 RFEVYHECFGKCKGIFDADAFVSEDSACVECLECGWKLSPKRFVRHVHSSL-ENSTCHWGFDSTN---WRYYLLLSMKke 339 
5C4V_B               101 --gTPEEKKLKIILEEMKEKF 119  human
6_pfamImport          77 eyqLADVEQLEAELDSFKSRF 97  
1_pfamImport          74 --gHPDYAQVVNLFETFKEQI 92  
ETN64852             361 --sDKNRDEHTQILQKIWNKE 379 
WGS:AANI:GJ24706-PB  273 --dVENREKYQRILDQLKEVE 291 
4_pfamImport          75 --iVDKREIYNEMLDNLKAKQ 93  
XP_009025482         188 ---KKQGEIVLNAWEDVKAMF 205 
EFX81507             181 ---PPD-Q-VMFAWEDVKAMF 196 
XP_009018725         214 ---SPN-EDLSHAWEDVKAMF 230 
XP_008204568         340 khtQQTYSKLDNFYSDLKKRH 360 
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