1L3E


Conserved Protein Domain Family
HIF-1a_CTAD

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pfam08778: HIF-1a_CTAD (This model is not part of the current CDD release)
HIF-1 alpha C terminal transactivation domain
Hypoxia inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1. It plays a key role in cellular response to low oxygen tension. This region corresponds to the C terminal transactivation domain.
Statistics
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PSSM-Id: 518498
Aligned: 9 rows
Threshold Bit Score: 61.6214
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1L3E_A         5 ESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQV 41  human
4_pfamImport   1 LFSLPQLTRDDCEVNAPLQGRQFLLQGEELLRALDHV 37 
Q6EHI4       740 SGGLPQLTRYDCEVNAPVQDRHHLLQGEELLRALDQV 776 zebrafish
XP_005996095 738 DSVLPDITSYECGAASPLQSSRHLIQVEDLLRVLDQT 774
XP_003758350 825 PYLLPELTRYDCEVNVPVPGSSTLLQGSELLRALDQA 861
XP_003962523 718 LFSLPQLTRDDCEVNAPLQGRQFLLQGEELlraldhv 754 torafugu
XP_018666946 698 SGILPELSLHDCEVNAPLPGRGFFPVGVECVHALDEV 734 vase tunicate
XP_005988922 765 FSVLPVLNSLDCEVNAPVHGRSRLLQGNELLRVLDQA 801 coelacanth
NP_001012371 620 LLTLPVLSGWECEVNAPLEHTSYLLQGTEIMAVLDQV 656 zebrafish
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