Conserved Protein Domain Family
CathepsinC_exc

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pfam08773: CathepsinC_exc 
Cathepsin C exclusion domain
Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases. This domain corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini. It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands. Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor.
Statistics
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PSSM-Id: 400909
View PSSM: pfam08773
Aligned: 31 rows
Threshold Bit Score: 145.496
Threshold Setting Gi: 340503546
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGR34889                      316 DLPVHCVKSEIV-GKWQIQISHPivkGNSrSMVTCGhevpdNPNTSFkasngkiqgvqqTFDIELTKDNKVLGE--LGEG 392 Ichthyophthirius multifiliis...
ESO10294                       22 DTPVSCMYEDIR-GKWVFYVGNG---GYD-NNINCStmgyeVSKILF------------QYKLELKYPNIVIDEf-NNEG 83  Helobdella robusta...
EFC36668                       23 DIPVHCLFHQVF-GDWTFYRTSTsfsNDV-VHNTCAltnplPNVNVD------------TIKLRLLAPDVVYDEq-GNEG 87  Naegleria gruberi...
EFC37894                       31 DLPVHCLYNSTApGVWEFELTDQnmsGDD-VAAKCDir--aPIQATR------------TMKVYLQMPDIAIDEk-GNTG 94  Naegleria gruberi...
EGR30116                       23 DLPIHCLKNQVT-GYWILQRGKIeatNNErKMVSCGhqspdNENTSYkalngkldvvenEEIIKINPDFTVSGD--KGTG 99  Ichthyophthirius multifiliis...
WGS:AAGF:cds.TTHERM_00445920A  23 DLPVHCVRSQIT-GKWLLKEGKVlasSNN-KPVSCGhqipdKAESSNsamggvlteverEYEVFLDEDFTVRGK--EGKG 98  Tetrahymena thermophila SB210...
A0E8K5                         14 dLPVHCVRHQIV-GKWQLEFTEPqikGSG--PLTCGhnvpdNERTSQvagqnt-fvktsTHEVILTAKNNVVQKk-KLQG 88  Paramecium tetraurelia...
A0DDP2                         26 DLPVHCVRHQIV-GKWQLQFTEPqikGSG--PLTCGhnvpdNERTSQfagqnt-fqqafTHEVVLTAKNNVVLKk-KLQG 100 Paramecium tetraurelia...
A0E1S5                         18 DLPVHCLRHQIV-GKWKMEVSDVqlrGVG--AVPCGhhvpdTQHSSYkagwed-frasdSFELTLGNDYTVTDKdrKQSG 93  Paramecium tetraurelia...
A0DZB1                         18 DLPVHCMKHQIT-GKWKMEVSQTklkGMG--AVPCGhhvpdSQQSSYqagfdd-fkavdTFEVNLSNDYSVQDKerKTSG 93  Paramecium tetraurelia...
EGR34889                      393 TWTMIYDEGWEIDYGGIKFMNFFKYSKKElsLF----YKIDCGKTLVGWYNN--YTELNRGCSQ 450 Ichthyophthiri...
ESO10294                       84 TWTMIYDEGFEVTIHNRKFFAFSKFTGNM--FN----STSFCNETFPGWSHD--VFGRDWACYY 139 Helobdella rob...
EFC36668                       88 FWTLIYDQGFEVVINKQKYFAFFNYTQQG--KV----VTSNCGQTFTGWYHDagIAVKKFGCFR 145 Naegleria gruberi
EFC37894                       95 FFTLVYDQGFEVVVGGNKYWAFFNYTTAGkdSQgndiIISNCDRTFTGWYHEakVKAKSWGCYR 158 Naegleria gruberi
EGR30116                      100 KWTLIYDEGWEIDYNNTKYTHFFKYYNQN--GN----YKTDCDNTLVGWFNS--YSVSQRGCSI 155 Ichthyophthiri...
WGS:AAGF:cds.TTHERM_00445920A  99 RWTLVYDEGWEIEYNGVKYTHFFKYAKDDs-GQ----YKSVCSQTLVGWFNH--IQKKSRGCSQ 155 Tetrahymena th...
A0E8K5                         89 KWTMVYDEGFEVDFSKYKCFAFSKYKTNY--SG----AYSYCGETLIGWYQN--TETNERGCYR 144 Paramecium tet...
A0DDP2                        101 KWTMVYDEGFEVDFMHYKCFAFSKYKTNY--SG----AYSYCGETLVGWYQN--TKTNERGCYR 156 Paramecium tet...
A0E1S5                         94 SWTMVYDEGFEVEHNGVKYFAFSKYEPNG--VD----YKSLCGETLIGWYNN--QKTGEKGCYR 149 Paramecium tet...
A0DZB1                         94 QWTMVYDEGFEVEHNGVKYFAFSKYAPNG--SD----YKSYCGETLIGWYNN--LKTGEKGCYR 149 Paramecium tet...
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