Conserved Protein Domain Family
CathepsinC_exc
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pfam08773: CathepsinC_exc 
Cathepsin C exclusion domain
Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases. This domain corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini. It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands. Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor.
Links
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Statistics
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PSSM-Id: 489875
Aligned: 23 rows
Threshold Bit Score: 153.216
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004040193 316 DLPVHCVKSEIV-GKWQIQISHPivkGNSrSMVTCGhevpDNPNTSFkasngkiqgvqqTFDIELTKDNKVLGE--LGEG 392
XP_002669412  23 DIPVHCLFHQVF-GDWTFYRTSTsfsNDV-VHNTCAltnpLPNVNVD------------TIKLRLLAPDVVYDEq-GNEG 87 
XP_002670638  31 DLPVHCLYNSTApGVWEFELTDQnmsGDD-VAAKCDi--rAPIQATR------------TMKVYLQMPDIAIDEk-GNTG 94 
A0E8K5        14 DLPVHCVRHQIV-GKWQLEFTEPqikGSG--PLTCGhnvpDNERTSQvagqnt-fvktsTHEVILTAKNNVVQKk-KLQG 88  Paramecium tetr...
A0DDP2        26 DLPVHCVRHQIV-GKWQLQFTEPqikGSG--PLTCGhnvpDNERTSQfagqnt-fqqafTHEVVLTAKNNVVLKk-KLQG 100 Paramecium tetr...
A0E1S5        18 DLPVHCLRHQIV-GKWKMEVSDVqlrGVG--AVPCGhhvpDTQHSSYkagwed-frasdSFELTLGNDYTVTDKdrKQSG 93  Paramecium tetr...
A0DZB1        18 DLPVHCMKHQIT-GKWKMEVSQTklkGMG--AVPCGhhvpDSQQSSYqagfdd-fkavdTFEVNLSNDYSVQDKerKTSG 93  Paramecium tetr...
XP_004031352  23 DLPIHCLKNQVT-GYWILQRGKIeatNNErKMVSCGhqspDNENTSYkalngkldvvenEEIIKINPDFTVSGD--KGTG 99 
XP_001023356  23 DLPVHCVRSQIT-GKWLLKEGKVlasSNN-KPVSCGhqipDKAESSNsamggvlteverEYEVFLDEDFTVRGK--EGKG 98 
XP_009011590  22 DTPVSCMYEDIR-GKWVFYVGNG---GYD-NNINCStmgyEVSKILF------------QYKLELKYPNIVIDEf-NNEG 83 

XP_004040193 393 TWTMIYDEGWEIDYGGIKFMNFFKYSKKElsLF----YKIDCGKTLvGWYNN--YTELNRGCSQGEL 453
XP_002669412  88 FWTLIYDQGFEVVINKQKYFAFFNYTQQG--KV----VTSNCGQTFtGWYHDagIAVKKFGCFRGIR 148
XP_002670638  95 FFTLVYDQGFEVVVGGNKYWAFFNYTTAGkdSQgndiIISNCDRTFtGWYHEakVKAKSWGCYRARR 161
A0E8K5        89 KWTMVYDEGFEVDFSKYKCFAFSKYKTNY--SG----AYSYCGETLiGWYQN--TETNERGCYRAIK 147 Paramecium tetraurelia
A0DDP2       101 KWTMVYDEGFEVDFMHYKCFAFSKYKTNY--SG----AYSYCGETLvGWYQN--TKTNERGCYRAQK 159 Paramecium tetraurelia
A0E1S5        94 SWTMVYDEGFEVEHNGVKYFAFSKYEPNG--VD----YKSLCGETLiGWYNN--QKTGEKGCYRAKK 152 Paramecium tetraurelia
A0DZB1        94 QWTMVYDEGFEVEHNGVKYFAFSKYAPNG--SD----YKSYCGETLiGWYNN--LKTGEKGCYRAKK 152 Paramecium tetraurelia
XP_004031352 100 KWTLIYDEGWEIDYNNTKYTHFFKYYNQN--GN----YKTDCDNTLvGWFNS--YSVSQRGCSIAKK 158
XP_001023356  99 RWTLVYDEGWEIEYNGVKYTHFFKYAKDDs-GQ----YKSVCSQTLvGWFNH--IQKKSRGCSQAIK 158
XP_009011590  84 TWTMIYDEGFEVTIHNRKFFAFSKFTGNM--FN----STSFCNETFpGWSHD--VFGRDWACYYGNK 142
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