5FVM,1AUE


Conserved Protein Domain Family
FRB_dom

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pfam08771: FRB_dom (This model is not part of the current CDD release)
FKBP12-rapamycin binding domain
The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the TOR proteins. This entry represents the FRB domain.
Statistics
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PSSM-Id: 518492
Aligned: 81 rows
Threshold Bit Score: 87.2545
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5FVM_A       1953 ELIRVAVLWHELWYEGLEDASRQFFGEHNTEKMFATLEPL-HEMLKRgPE--TLREISFQNSFGRDLNDAYEWVLNYKRT 2029 Kluyveromyces...
XP_001311334 1609 ELMRVACTRFELCYNCI----RDTLFEPN-EFTTKYLHQL-FEQNSK--EneTFLDVSFSREFGNLLNLLEEWVKKYEET 1680
XP_001581532 1712 EMMRVSVSWFELAYQCIDESSHEFCPDVNKQMMLKFLDPL-KEILSK--KceTCMESKFFAQNYSHLKIAFGLLKKYEEN 1788
XP_001317016 1700 ELIRIAVLWWDSWYSTLDNATAITDD----NLLIQTIRDLiKETLRP-PE--TANEVSFIRSLGPYVHDVIDALDAFDKN 1772
XP_001310804 1626 gLIRACTTKVELWADAM-SAMTVPLKTNNMRQMRAILNPL-IDDLSY-PQ--TDDDRAFAKDYGQIVKSLAIEFKTFMKN 1700
XP_001307630 1785 gLLRSASSWFEEWLMSIDLASR-ADHEHNKAKMESILQRQ-FVKYQN-PK--CDFDKWFVKLHDQLIQQAKSCFVQ---- 1855
XP_001318765 1690 gMHRAAVSWNELWLTGLDNASR-ANGIGDIEQSYQVIQGL-FDMLEK-PQ--CQMDHQFIKTMGPQISRAKTMFERA-KT 1763
XP_001316510 1727 gMQRCAISAVEHWLTALDCAIK-YHKSGDTENVVKLIERE-YENLSK-PQ--CEQDKIVARAFTVQLQRVRGAFDRY-KA 1800
Q38AC2       1891 ELVRCAVLWPELWINELGRALYQWERQRSAENLLLAMGPL-LEQLKR-PE--TMAEAQFAAELRQPLENACCHVERAVSS 1966 Trypanosoma b...
XP_001470005 1993 ELVRCAVLWTELWFDELERAWFQWGRDKNAHNVFLVLQPL-LEQLSH-PN--TLAESHFVAEFGELLGGACEYVEKAAST 2068
5FVM_A       2030 KDINNLNQAWDIYYNVFRRIS 2050 Kluyveromyces marxianus
XP_001311334 1681 KDHTHKNMIYNVMGQIWLKIK 1701
XP_001581532 1789 DDLGSLNEVWDHFSTVFNKLR 1809
XP_001317016 1773 RSHENKSHLWRQLVTVYNMVK 1793
XP_001310804 1701 PNKESLEKMWKICRDLYNQLK 1721
XP_001307630 1856 NTPESRKMMWDIFKHIFKQLT 1876
XP_001318765 1764 NDENSIKMMWAGFKEIYQSLN 1784
XP_001316510 1801 GDITVSKAMWDGYRSIFTKLD 1821
Q38AC2       1967 RHEQFMEEARRIFVSIERRIR 1987 Trypanosoma brucei
XP_001470005 2069 GNNVYMEDAWNRFKTAVKRMD 2089
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