3EMM,6R3Y,3IA8


Conserved Protein Domain Family
THAP4_heme-bd
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pfam08768: THAP4_heme-bd (This model is not part of the current CDD release)
THAP4-like, heme-binding beta-barrel domain
This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organisation. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).
Links
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Statistics
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PSSM-Id: 518489
Aligned: 132 rows
Threshold Bit Score: 58.3539
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3EMM_A          20 VAPLSYLLGTWRGQ--GEGEYptIPSFRYGEEIRFSHSGKPVIAYTQKTWK-LESGaPMHAESGYFRPRP-DGSIEVVIA 95   thale cress
XP_032454902    10 LRPLAWLEGVWRTEslGSGKFptINSFKYCEEITFSSIGQPMLNYTAQSWH-PEkknPMHREVGFLKIVPnTNKVSLFLS 88  
EFN89895        12 LSMLSWLEGTWITEepAAGIFptIKPFNYHDEINITSIGQPLFNYIAQSWD-PETGtPMHREIGFLQIAPgTNQVSLNLI 90  
XP_011061892    12 mhVLAWLEGTWITDepAVGTYptIKPFNYYDEINITSTGQPIFNYIAQSWH-PDSGtPMHRETGFLQILPgINKIVLSLI 90  
14_pfamImport    2 LESLAWLEGTWRTEnqGSGKYptIKDFSYYDEISFMSLGQPMFNYTAQSFSnSDLKkPMHRETGFLKVNPgTNQVTLISA 81  
XP_025265147    10 LEPLAWLEGTWRTd-cGSGNYptIKEFKYYEEISFTYIGQPMFNYTARSYSiSEPKkPMAQSTGFLKVDPkTNKIFLILA 88  
XP_974833       13 VKPLCWLIGHWKSIk-AEGIYptIEPFTYCDEIVFESIGQPLLNYTSKTWH-PEKGnPMHFESGFLRINPgTNNVAFMIA 90  
XP_001863919     8 LKPIQWLIGSWESIs-AKGHFptIKDFTYNEVLKFESVGQPILNYEARSRH-SVTGaPMHLESGFLRIKPgSNQLAFMVS 85  
XP_049532403     8 LKPIQWLIGTWESIs-AKGSFptIKDFTYKEVIKFESLGQPLLNYESRSKH-PVSGaPMHLESGFLRIKPdTNEIAFMVS 85  
XP_001632698    15 LAPVSWLVGKWEGE--GRGEYptIQPFTYRETVEFNNFGQPNLAFSSKSWN-SKTNaPMHFESGFLRIMPsTTKVALMLA 91  

3EMM_A          96 QSTGLVEVQKGTYNv-dEqsIKLKSDLVG-----NASK--VKEISREFELV-DGK-LSYVVRMSTTTNP-LQPHLKAILD 164  thale cress
XP_032454902    89 HNFGLTTVEEGEVV---DnaVQLLSTSVSrt-ieGSKPpaVLQIKRELKLV-EDA-LHQTVYMSTETRPeLTEHLHAVYK 162 
EFN89895        91 NNLGMVTIEQGNLL---NktIDLKGNNVVmt--dIEKSpaVTLTRRVFKL--DGDqLEQIFYMATSKTPeLTEHLHAKhd 163 
XP_011061892    91 GNIGVFTVEEGDlmskdNntIDLNSNNILatdasIPSFspLTKTRRVYKRNgD-N-LELIFYMATSKTPeLTEHLNAKYR 168 
14_pfamImport   82 HNFGLTTIECGEIT---DktINLNSTDITri--kEAKIphVTQVRREFKLH-DNC-LEYIFYMATSNTPvLTEHLQAKYT 154 
XP_025265147    89 HNFGLTSIEEGEII---NnvVCLDSIDILrm--kGAKPpqVTQMRRIFKLD-DNN-LEHVFYMATSNTPeLTEHLRAKYV 161 
XP_974833       91 HNFGVTSLEEGVv---tGttLKCKSTQISrm--sFARDppVLAIEREFKLVeNGN-LEITVYMETAKTA-LTQHLKAVYE 163 
XP_001863919    86 HNFGLAVLEEGIa---tAdgLELESRSINrm--sFAKDpsVKCIKKVYKLNaDGT-LEIRTDMETSNTA-LTNHLVAVYK 158 
XP_049532403    86 HNFGLVVLEEGTg---dEqgLQLVSKSVDrm--sFAKDpaVKKIQKRYRLNaDGT-LQIETDMETSNTP-LTNHLVAVYK 158 
XP_001632698    92 QNIGVTELLEGEv---eGkvLHLTAQAIGrm--sFGKPpaVLKTERVYMLVdENT-LEFKQFMETETTP-RTQHLQATYK 164 

3EMM_A         165 K 165  thale cress
XP_032454902   163 R 163 
EFN89895       164 v 164 
XP_011061892   169 K 169 
14_pfamImport  155 K 155 
XP_025265147   162 K 162 
XP_974833      164 K 164 
XP_001863919   159 K 159 
XP_049532403   159 K 159 
XP_001632698   165 R 165
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