6M6X,4FGV


Conserved Protein Domain Family
CRM1_C

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pfam08767: CRM1_C (This model is not part of the current CDD release)
CRM1 C terminal
CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat.
Statistics
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PSSM-Id: 518488
Aligned: 26 rows
Threshold Bit Score: 284.895
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6M6X_C        665 QLGHIYYNMLQLYRAVSSMISTQVAAEGLIATK----TPKVRGLRTIKKEILKLVETYISKAR----------------- 723  Saccharomyces...
EDO26923       64 QLGRIYLDMLNVYRCLSENISMAISENGELVMK----QPLIRAMRTVKTEVLRLISTWVSKSN----------------- 122 
Q23089        719 QLGNIYSDLLSLYKILSEKVSRAVTTAGEEALK----NPLVKTMRAVKREILILLSTFISKNG----------------- 777  Caenorhabditi...
Q7PMB7        691 QLGRIYLDMLNVYKIMSENITQAISLNGLSINN----QPLIKAMHVVKKETLTLISEWVWKSN----------------- 749  Anopheles gam...
EDX04246       28 QLGRIYLDMLNVYKITSENIIQAIEVNGVNVNN----QPLIKTMHVVKKETLNLISEWVSRSN----------------- 86  
XP_001645797  709 QFEKILEDVVHLYGFSTKFIER-IENTSNNATEfednINILKLLRGIKRNILKLVKLLMRNVH----------------- 770 
A0D4D4        233 QLLPTYN---QIYLFYSQSIQQQVLAQGVVVMG----YYTVKKQRAVKKEILKLYATYFQNNDqe--------------- 290  Paramecium te...
Q7RP59        168 QLNLVFFDFLKIYQLYSKYINMEVEANGTKRIK----HAQFRNLFLMKREFLHLIETTIERSCyniqeleeallkreqkk 243  Plasmodium yo...
XP_001327132  673 QLRIIFNQLMEVYSRYSNLLQQFIGEPGYSETK------EANCFKRIKSKIVLIINDYILKTP----------------- 729 
Q54EV7        700 QISKIYLDLLNVYRTYSDHISR-----NPNIYR----ETLGQAMRSVKKETLKLLETFIEKSS----------------- 753  Dictyostelium...
6M6X_C        724 --------------------NLDD-VVKVLVEPLLNAVLEDYMN-NVPDARDAEVLNCMTTVVEKVGHMIPQGVILILQS 781  Saccharomyces...
EDO26923      123 --------------------DPKL-VCDNFIPPLLDAVLGDYQR-NVPGAREPEVLSTMATFINKLEANVTENVSQIFDA 180 
Q23089        778 --------------------DAKL-ILDSIVPPLFDAVLFDYQK-NVPQAREPKVLSLLSILVTQLGSLLCPQVPSILSA 835  Caenorhabditi...
Q7PMB7        750 --------------------DPKM-VMENFIPPLLEAVLFDYQRtKVPNAREPLVLSTMASIVNRLQAVITPEIPKIFDA 808  Anopheles gam...
EDX04246       87 --------------------DNQL-VMDNFIPPLLDAILLDYQRcKVPSAREPKVLSAMAIIVHKLRQHITNEVPKIFDA 145 
XP_001645797  771 --------------------NQEE-VLNFINSEFLDVVLTDFVK-SENEVKEVEVLSCMISLVSSTNVTISDYVDKIYDA 828 
A0D4D4        291 ------------------llNKNYqLKNSLVIPICN-LLDEYSQ-SINEQKEPELLLTFKYMLEKFLAPIEDLVPLILKG 350  Paramecium te...
Q7RP59        244 mkneidesidvhlptveeakQINFqMTSNILNVLLETILVDYRD-SNPHIKDAEVFSLLSTVFKKIENVTCPILPTVLNY 322  Plasmodium yo...
XP_001327132  730 --------------------DVES-VANELIEPISQTIILEYEN-SHPLGRVPEVLSLVTSMSNKMKKVFGEVLPNIYGP 787 
Q54EV7        754 --------------------DKQV-IYSNFLQPLLEAVLGDYRT-NIPETRDPEVLSLMTAIITSLKQLVHPEVPKILEA 811  Dictyostelium...
6M6X_C        782 VFECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNIE 861  Saccharomyces...
EDO26923      181 VFECTLNMINKDFEEFPEHRTNFFLLLQAVVQHCFQALLKIPPEQFKLVLDSIVWAFKHTMRNVADTGLHILYSLLKNME 260 
Q23089        836 VFQCSIDMINKDMEAFPEHRTNFFELVLSLVQECFPVFMEMPPEDLGTVIDAVVWAFQHTMRNVAEIGLDILKELLARVS 915  Caenorhabditi...
Q7PMB7        809 LFDCTLDMINKNFEDYPQHRTNFYELLQAVNMYCFKAFLSIPPEQFKLVFDSIVWAFKHTMRNVADTGLNILMQMLQNLE 888  Anopheles gam...
EDX04246      146 VFECTLDMINKNFEDFPQHRLSFYELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILFKMLQNLD 225 
XP_001645797  829 IFFTTLNMIKGDLVEYPEHRIEFYKLLEQINKKYFNTLIKLSDQKFKLFIDTICWGIKHTNRDIEIRSLQIGLDLIHNIE 908 
A0D4D4        351 LFDATIRLISQDFNSYPDHRINFFEFLRSCVQYHLVALFNMPQDQFKLMIDCIVWAFKHQVPNLQELGLDVLYYILQQVN 430  Paramecium te...
Q7RP59        323 VLLPTIDMIKNDFSSYPEHREKFYNFLDACVRHCFDYLFTLDSEIFNTFIQSLLWAIKHEHPSVADHGLKITHQFLHNVI 402  Plasmodium yo...
XP_001327132  788 IFNETLAMIKDDFSIFPEFRVPFFKFVDNIVTNYISIMLSAPDQTFSDFIETIKLGCYHTIPEVCIISLSATEHLFKSIK 867 
Q54EV7        812 VFETTLSMITKNFEDYPYHRINFFNLIRAINSNAFTVFHNLHPQQFKLLIDCVVWAFKHTERNISETGLHILKELIENVS 891  Dictyostelium...
6M6X_C        862 Rmg-nVPFANEFHKNYFFIFVSETFFVLTDSD--HKSGFSKQALLLMKLISLVYDNKISVPLYQEA-EvPQGTSNQVYLS 937  Saccharomyces...
EDO26923      261 A----EEASQSFYQTYYITIVQHVLSVVTDTS--HTAGLTMHATILAHMFSLAESGKITQPLFNSS-E-AQYASNQVCTA 332 
Q23089        916 Eq--dDKIAQPFYKRYYIDLLKHVLAVACDSSqvHVAGLTYYAEVLCALFRAPEF-SIKVPLNDA----NPSQPNIDYIY 988  Caenorhabditi...
Q7PMB7        889 Qh---PQAAQSFYQTYYTDILMQIFSVVTDTS--HTASLQNHATILAYMFSLVEAGRITVKLGP-------SDDNVLNIQ 956  Anopheles gam...
EDX04246      226 Qh---PGAAQSFYQTYFTDILMQIFSVVTDTS--HTAGLPNHAIILAYMFSLVENRKITVNLGP-------IPDNMIFIQ 293 
XP_001645797  909 KlghnRVFSINFYRAHYLTLLSEVFYAMTDPD--HKAGFNRQSLLLMKLVSLIENGALSVSVFRNDdM-EPRISNHTFLI 985 
A0D4D4        431 Sd---AVVANQFYSLYHLRLLKDILEILTDNL--HASGFKHQSQILMILFQVASNQQITAKLSN-----EQVGSNLEFIS 500  Paramecium te...
Q7RP59        403 Vk--kKEYLDEFCKAFYYIILNEVFKTLTDSF--HKSGFHYQTIILMNLLRLLEFEVINIPEAE---------ITKPHII 469  Plasmodium yo...
XP_001327132  868 Dt--nMNRYRQFLSNFYMDILVQVIKVTTDTY--HKFAFREEVNLIRKLL------STQTQQLN---------------G 922 
Q54EV7        892 Kn---SDVANVFFKTYLVSLLNDILYILTDSF--HKSGFALECDILRMMFQVVENGVVKIPLFDPQ-Q-ANFPSNSEYVK 964  Dictyostelium...
6M6X_C        938 QYLANMLSNAFPHLTSEQIASFLSALTKQCK-DLVVFKGTLRDFLVQIKEVG 988  Saccharomyces cerevisiae S288C
EDO26923      333 CFVIDR-----SSLGEARTQDFSWGVFILGQ--ARWFASA------KIKEYR 371 
Q23089        989 EHIGGNFQAHFDNMNQDQIRIIIKGFFSFNT-EISSMRNHLRDFLIQIKEHN 1039 Caenorhabditis elegans
Q7PMB7        957 EYVAMLLKSAFSHLTGNQIKIFVTGLFNLDQ-DVHAFKEHLRDFLIQIKEVT 1007 Anopheles gambiae str. PEST
EDX04246      294 EYVASLLKSAFTHLSDNQVKVFVTGLFNLDE-NVQAFKEHLRDFLIQIREAT 344 
XP_001645797  986 EYMSNLINNAFTQLSREQIIVFLSALTKLYD-NKKRFNGILRDFLVQSKEFG 1036
A0D4D4        501 QYLVNSLYNAFPNVSKQQTELHIARMFQNLN-NAHNFRQELSDYLINLKQFQ 551  Paramecium tetraurelia
Q7RP59        470 KHVQTFLTQSFENLNQKQIETFSVDMFNFCVeSPLTFRSFVRDLLISLKEFS 521  Plasmodium yoelii yoelii
XP_001327132  923 ETIASAIQDLFPNRDYDSLVNYMSSLIANSN-NMVEFQHIFREFVISTTLFS 973 
Q54EV7        965 EIVVTFLSAS-PNVSRPQIQAFVTRLFNLANiNNNDFKSATRDFLITLKEWK 1015 Dictyostelium discoideum
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