1Q1V,7Z0O


Conserved Protein Domain Family
DEK_C
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pfam08766: DEK_C (This model is not part of the current CDD release)
DEK C terminal domain
DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins, and in protein phosphastases.
Links
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Statistics
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PSSM-Id: 518487
Aligned: 231 rows
Threshold Bit Score: 29.6774
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1Q1V_A          12 PTDEELKETIKKLLASANLEEVTMKQICKKVYENYPTyD-LTERKDFIKTTVKELI 66   human
18_pfamImport    1 SVETLIRDRLKQVMMTMDLDNCTCKQVRLELENVI-D-MdLTAYKRYIDTEMFNIL 54  
XP_004345410  1039 ELD--VINKLREFMMCSDLDSVTPKEMRTALESHF-N-IdMNYCKKFIDEKILVIM 1090
XP_001742344   350 ELEQRIISKLKEIMFKSDLDTITSKQLRLQLEAEF-D-MdLKKYRKIIDQQMITVM 403 
33_pfamImport    1 SNERLIKEHLRDIMRTEDLDNLTSKMVHTALESRIGF-D-MRIYKEYIDNEILVTM 54  
XP_021336912   241 SVEREIKAQLRDIMRTEDLENITSKQVRTSLESRIGI-D-MKDYKEYIDNEMMVTM 294 
57_pfamImport    1 MMERRIKSQLREIMWKEDLENITSKQVRCALEQCL-G-VdMKDYKEFIDNEMMVTM 54  
51_pfamImport    1 LSEQAVRALLREVMAAADLENVTSKEVREELERRT-G-HsLAEHKDFIDNEMLLVL 54  
XP_012376332   268 QMEQAIRAELWEVLDTSDLESVTSKEIRQALEVRLGC-P-LQQYREFIDNQMLLLM 321  nine-banded armadillo
XP_029703285   237 SKEKLIKKHMTDIMSTEDLDNLTCRMVYEALQERI-G-FdMKPFKKYIDNEILVTI 290  torafugu
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