Conserved Protein Domain Family
Ca_chan_IQ

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pfam08763: Ca_chan_IQ 
Voltage gated calcium channel IQ domain
Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).
Statistics
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PSSM-Id: 400901
View PSSM: pfam08763
Aligned: 31 rows
Threshold Bit Score: 92.2748
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESN94675     1421 TTMFALVRESLGIKMg-dAeVMDQL--DWELRNILLDLFDLKPAD--LDILLP-PIEEyvGKKVSVGKVYASMLLVDAWK 1494 Helobdella ro...
XP_002109775 1366 ATLFALIRTSLKIKV-----REDQHeaDAELCQIIRKIWPQVTSRt-LERILPqVEHG--ARHLTIGKIYAALIIYEYYK 1437 Trichoplax ad...
EDV29728     1386 ATIFALVRKQLKIKLd---gNLDLR--DRELRNIIKRIWPRTPNKl-LDEILF-NFS---DNDITIAKIYALLIIRNFIR 1455 Trichoplax ad...
XP_004989719 1330 ACLLAIVRNQLHIKTsyldgSWEQR--NYDLRKLLEKLYDP--PKeqLDRMLP-PPS---KRNVTIGVLYAVYLLQEIYR 1401 Salpingoeca r...
XP_021201888 1497 ATLFAVVRTQLQIKTt---gVIDEC--NTQLRAIIKRVWKRTSPKl-LDQVVP-PPGD--PNEITVGKFYATFLIQDYFR 1567 domestic silk...
XP_018667169 1465 ATLFALIRTSLNIKTe---gNIDQA--NEELRAVIKKIWKRTSIKl-LDQIAP-PAG---NDDITVGKFYATYLIQDYFR 1534 vase tunicate
3_pfamImport    2 ATLFALVRTALKIKTe---gKHSLA--EGQVRMSVFSGWNFKLIEi-XDQVVP-PAG---DDEVTVGKFYATFLIQDYFR 71  
EGW06086       15 ATLFALVRTSLKIKTe---gNLDQA--NQELRMVIKKIWKRIKQKl-LDEVIP-PPD---EEEVTVGKFYATFLIQDYFR 84   Chinese hamster
CAE50430     1372 ATLFALVRTALKIKT---DgNPDQE--NEELRIIIKKIWKRTKPKv-LDEVIP-PPA---EEEVTVGKFYATFLIQDYFR 1441 zebrafish
VVC34211     1509 ATLFAVVRTSLHIKSe---gNIDDA--NAELRAVIKKIWKRTSPKl-LDQVVP-PPGV--DDEVTVGKFYATFLIQDYFR 1579 Cinara cedri
ESN94675     1495 QF 1496 Helobdella robusta
XP_002109775 1438 RY 1439 Trichoplax adhaerens
EDV29728     1456 RR 1457 Trichoplax adhaerens
XP_004989719 1402 EN 1403 Salpingoeca rosetta
XP_021201888 1568 RF 1569 domestic silkworm
XP_018667169 1535 KF 1536 vase tunicate
3_pfamImport   72 KF 73  
EGW06086       85 KF 86   Chinese hamster
CAE50430     1442 KF 1443 zebrafish
VVC34211     1580 RF 1581 Cinara cedri
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