Conserved Protein Domain Family
COP-gamma_platf

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pfam08752: COP-gamma_platf 
Coatomer gamma subunit appendage platform subdomain
COPI-coated vesicles function in retrograde transport from the Golgi to the ER, and in intra-Golgi transport. This is the platform subdomain of the coatomer gamma subunit appendage domain. It carries a protein-protein interaction site at UniProt:P53620, residue W776, which in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2.
Statistics
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PSSM-Id: 400893
View PSSM: pfam08752
Aligned: 128 rows
Threshold Bit Score: 122.663
Threshold Setting Gi: 122096157
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009268155                   647 TTNITSIPEF-A--GYGAPLHTSPPVHLTEEETEYVVSVQKHLF--SEHVVFEYHVRNTVPEAVLDGVSV--LMGLgdvG 719  Wallemia ichthyophaga EXF-994...
Q1EQ35                         591 NENQKKMEEIfG--NLGKPIKSCPEILISGIDTEYQVSVTKILY--ERHIALKCMIKNTLNEYQLENVTIniTGQL---K 663  Entamoeba histolytica...
Q1EQ36                         591 SNEVKKEQEIiE--GFGEVIKKS-EVTLTTTGSEYDVVCKKMIY--KNNVVLLYSITNTLTDYCLSNVSIeiGIEK---G 662  Entamoeba histolytica...
XP_002141358                   645 CEKLATIIMR-E--DLGKHMFTSIATPLTENEAEYIVHLRKHFFneGRIIVLEFQIVNTLNEQILKDVSIefGVIP---S 718  Cryptosporidium muris RN66...
XP_001615564                   736 siVSEDVSHFiEkhQMGTLKMVGKSVPLTENEAEYTVFVKKYIY--ERHILLQFTIQNTLSEQILADVNM--QINS---- 807  malaria parasite P. vivax...
XP_002259454                   706 fvlseDVSNLlEkyQLGALKMVGKSIPLTESEAEYTVLVKKYIY--DKHILLEFIIQNTLSEQVLADVNM--QINS---- 777  Plasmodium knowlesi strain H...
EED89061                       644 aAAVYAIPEL-A--SLGRVFRSSNPTELSEEETEYVVRCIKHVM--PEHIILQFLIQNTVEDQRLVNCSV--TIEG---D 713  Thalassiosira pseudonana CCMP1335...
XP_002186065                   647 AAAIYAIPEL-A--NLGRAFRSTAPVHLTESETEYVVQCTKHIF--ASHVVLQFSVQNTIDDQRLDNVTV--LLDD---S 716  Phaeodactylum tricornutum CCAP 1055/1...
A0DMU5                         631 KKLFKESTIF-C--DYGVLRKSSRAQNLTDSKCEYLVTVVKHFF--DNHIILEYKVKNTLDNVTLNDVSLelTIKN---V 702  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00444320A  661 AQQFASSAIF-Q--GYGPLRHISNGGDLTDKNASYLVSYVKYFF--DDYVVLEFLVKNKAQDQILKDVKVklDLNN---E 732  Tetrahymena thermophila SB210...
XP_009268155                   720 g-sLRED-FIL----PIDTLTVADgERSTYVSYSfiddeG----------DgnGDNAgypTGA-LSNTLTFTTKE-VDPD 781  Wallemia ichthyophaga EXF-994...
Q1EQ35                         664 ---HYKMvKNI----KINNLPPQC-EDMAVIILE----------------------KdknEPEnIPLQMTYTMRE-INTI 712  Entamoeba histolytica...
Q1EQ36                         663 ---DYKIiEQS----TISSLPAQG-SDIIKVVLD----------------------RpdsLIGtFSNKLIYTLKEnIEDD 712  Entamoeba histolytica...
XP_002141358                   719 s--SISIiGTV----TIPILESNQ-MGSVYVLLKn-----------------lQDEQipiKINsWSCRLSYILCEyCDPD 774  Cryptosporidium muris RN66...
XP_001615564                   808 ----FDKkWTVlektTIPNLFFNA-PQNLYVLLG-----RnnapplgepmLeaPPSGdyqVNQhFQLSLRFLTKEn---- 873  malaria parasite P. vivax...
XP_002259454                   778 ----FDKkWTVlektAIPNLYFNA-PQNLYILLG-----Rni------plQeePINEnyqVNQhFQLSLHFLTKEn---- 837  Plasmodium knowlesi strain H...
EED89061                       714 s-eCFEVaGEI----AAESIKYGE-TANAFTVIN-------------------RNTEaplAPCnFECVLRFGVIQ-VDPK 767  Thalassiosira pseudonana CCMP1335...
XP_002186065                   717 eseIFTVsGEI----ACDGIKYGD-TKHCFAILE-------------------RNAEiqlTPShFTCELRFTVVQ-VDST 771  Phaeodactylum tricornutum CCAP 1055/1...
A0DMU5                         703 ---NLQFeRIV----PAKQIQPQC-ASNILVGLQ-------------------FNPNlrlVSSnIQSILTFTVNE-NGTT 754  Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00444320A  733 ---NIQVeKIV----AATEIKEEE-ASNIFVALA-------------------RNPEfkvIAFsSQCFLTFQVQD-IGAN 784  Tetrahymena thermophila SB210...
XP_009268155                   782 SGMVeEE--GYADEYQVDDVELG 802  Wallemia ichthyophaga EXF-994
Q1EQ35                         713 TGELtES--VQEDEYPLDSIQIK 733  Entamoeba histolytica
Q1EQ36                         713 T--------GDEDEYIIDNVSLN 727  Entamoeba histolytica
XP_002141358                   775 N--------GYNDIFTVEPINFS 789  Cryptosporidium muris RN66
XP_001615564                   874 -----EMdeGFPDSYSINPLGVQ 891  malaria parasite P. vivax
XP_002259454                   838 -----EMdnGFPDTYSINPLSIQ 855  Plasmodium knowlesi strain H
EED89061                       768 SGEDeSD--PFDEEYPLEELELA 788  Thalassiosira pseudonana CCMP1335
XP_002186065                   772 TGEEeGD--KFEEEYPLEDLEIA 792  Phaeodactylum tricornutum CCAP 1055/1
A0DMU5                         755 ----------YQDEYQTEDFTIT 767  Paramecium tetraurelia
WGS:AAGF:cds.TTHERM_00444320A  785 GKVIs----EYADEYQLDDVQVT 803  Tetrahymena thermophila SB210
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