8QCI,6RBF,7PP6,7PP6,7QCN,7KWO,7KWO


Conserved Protein Domain Family
C8

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pfam08742: C8 (This model is not part of the current CDD release)
C8 domain
This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.
Statistics
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PSSM-Id: 518474
Aligned: 546 rows
Threshold Bit Score: 37.6967
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8QCI_B          199 FC-G-PLASGtggP-FTTCHAHV-P--PESFFKg-CVLDVCMG-G------G--D--H------DILCKTLASYVAACQ- 253  human
9_pfamImport      1 MC-Q-AVR-H---PsFGACSVSV-N--IQDFLSr-CVENTCEClKanagaeG------------SCRCDLLQQFVGQCL- 57  
371_pfamImport    1 LC-N-AIK-H---PnFLACDKAV-N--YKQFVSk-CIESTCEClQqn---gGn-E--K------SCKCNILQGFVKQCLa 58  
374_pfamImport    1 MCkAaIME-E---P-LSKCGLEV-N--LDKLLSq-CVESICLCmQ------S--S--Nss---eDCRCQALLEIVTECQ- 57  
P98092         1809 LC-N-VIAEE---P-FSQCGKVL-N--LDKWRHi-CLEKICECtDlvvngtKrtE--E------QCRCLVLQQMAAECLa 1870 domestic si...
126_pfamImport    1 ICrR-FFL-K---T--KNCLQDN----NSHYHRl-CKENICGFeN---------S--Q------SIFCPFFQEVASQCN- 50  
127_pfamImport    1 ICrQ-FFQ-E---I--KDCVRYN----NSHYQQl-CEENIFGF-----------EnsQ------SVFCPFFKEFASQCN- 50  
129_pfamImport    1 VCsQ-FFR-K---T--KSCLQDN----NSHFHQl-CRDNIFGFeN---------S--H------EVFCPFFQEVASQCN- 50  
NP_524060      2896 LC-N-IIH-H---PtFARCHKAV-N--YKQFLNnyCLEAACNCmManngdpA------------ACKCNILESFVKKCL- 2953 fruit fly
XP_046440020   3271 KC-S-FLRQD---P-FSQCHGSDeAalDKAIFR--CVDIMCDCmGsl---kDklI--TeidaadTCACQAMSVMAVECH- 3336 common wate...
8QCI_B          254 AAg-VV-I--EDWRAQVGCE 269  human
9_pfamImport     58 AVn-RH-LqlTSWRSVHRCN 75  
371_pfamImport   59 VKpnVKl---DTWRAVHNCE 75  
374_pfamImport   58 VK--MPrLdlSIWRVEHDCP 75  
P98092         1871 ADa---gVdlASWRLMMDCP 1887 domestic silkworm
126_pfamImport   51 QSr-INrF----WRRLTRCA 65  
127_pfamImport   51 QSr-INrF----WRDLTKCA 65  
129_pfamImport   51 QSr-INrF----WRRLTRCE 65  
NP_524060      2954 SVnpLVqL--TTWRAVAQCE 2971 fruit fly
XP_046440020   3337 DE--LPtVdlTGWRSKYDCA 3354 common water flea
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