Conserved Protein Domain Family
PalH

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pfam08733: PalH 
PalH/RIM21
PalH (also known as RIM21) is a transmembrane protein required for proteolytic cleavage of Rim101/PacC transcription factors which are activated by C terminal proteolytic processing. Rim101/PacC family proteins play a key role in pH-dependent responses and PalH has been implicated as a pH sensor.
Statistics
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PSSM-Id: 400879
View PSSM: pfam08733
Aligned: 76 rows
Threshold Bit Score: 176.245
Threshold Setting Gi: 387513942
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCK68758      91 CHASILGSGFLSIYdn---mSKPLifnnERYRNWTIAYPtlliqCtnrtynatnivhynetfpsqennftavlkefvhny 167 Kazachstania na...
XP_011272748  24 fdVYELTAGTITTPekfielSFPAy--yITNITSAVFNStefknevm--------------------------------- 68  Wickerhamomyces...
XP_002614600  60 CSVYSLTSGSLVLQdyf-shQWSAnl--tdFVPAYYATN-----Csv--------------------------------- 98  Clavispora lusi...
XP_001382315  18 CSVYSLTSGFIQFQdfrppyTWNNws--seFLPAYYITN-----Csi--------------------------------- 57  Scheffersomyces...
CCE43511      31 CSVYSLTNGTIKLLdyy-nqTWNNatslHHLLPAYFITN-----Csi--------------------------------- 71  Candida parapsi...
EDK43106      38 CSVYSLTNGTIRLLdhy-nqTWNNdlhlHEYLPAYYITN-----Csi--------------------------------- 78  Lodderomyces el...
Q5AHB5         3 CSIYHLNTGVISLLdyf-nkTWVNqs--taILPAYYITN-----Csv--------------------------------- 41  Candida albicans
XP_002546883   7 CSIYHLNTGHLSILdai-nnTWDNds--tvMLPAYYATN-----Ctv--------------------------------- 45  Candida tropica...
XP_004202267  12 CSLYALLAGSILLHdyf-ndTWSGnhshR-ALPGYYFTN-----Csd--------------------------------- 51  Pichia farinosa...
Q6BNL3        16 CSIYALTSGTIAFQdyh-nhSWSQnytkY-FLPAYYLTN-----Csi--------------------------------- 55  Debaryomyces ha...
CCK68758     168 tmsmDDIydd--------------------------------------teRMVYKDKFVDGILIITFSQTAVCVASWMVF 209 Kazachstania na...
XP_011272748  69 ------------------------------------------eisnelepMFYNKESFVGGVATISFVLSGTTTASWMMF 106 Wickerhamomyces...
XP_002614600  99 --pdLVAhisnqsvsdadvl------------------rwmrdfknnpynISDNGDSF----VALLYMISGSCVSCWMLE 154 Clavispora lusi...
XP_001382315  58 --pdLIQlviesnitgtdd--------------------qqdklinspynDRDNGDTF----VALLFMVCGSCVSSWMLA 111 Scheffersomyces...
CCE43511      72 --phLIDlvsqhensnssys-----------------aegplkfegspynERDNGDTF----IALLFTLCGSCVSCWMLS 128 Candida parapsi...
EDK43106      79 --pqLIDlvemekydnesslptttttttttttnngalshvvsnnennpynQKDNGDTF----IALLFTLCGSCVSCWMLS 152 Lodderomyces el...
Q5AHB5        42 --edMLSynnitsdpky------------------------lafdyspynKRDNGDTY----VALLFVLSGSCVSMWMLS 91  Candida albicans
XP_002546883  46 --tdMITflnqtldpyf------------------------mdfnyfpynKRDNGDTL----VALLFVLCGSCVSMWMLS 95  Candida tropica...
XP_004202267  52 --sdLSYlqsvkgltaqnit------------------dwvknnpyvdvaSTDNGDTF----IALLFSISGACTASWMLT 107 Pichia farinosa...
Q6BNL3        56 --adLTDisllnnlhsynlt------------------kweygqryhtydKTDNGDAF----VALLFTISGTCVSCWMLT 111 Debaryomyces ha...
CCK68758     210 LIILFLPANNYNt--kLNIVKVYVLLFALVQSVYLQKASAeVFRTQYMADIQDASYYKSHIMDSVGYRICEVFIHVMGLL 287 Kazachstania na...
XP_011272748 107 LLLFL------AsntiPNSLILTNLFFSVSHSVMLVKLTK-ILQCQYSQNYSDMDEVKNCITFGTSYLVVRSISTLLVWI 179 Wickerhamomyces...
XP_002614600 155 LMFVLSPKYKRK----PLLTHLATVMYSVVLTIILAQITA-VSRDEYYSDTLDMIKILNIVNDKRKYPTAITISQLLTNL 229 Clavispora lusi...
XP_001382315 112 LLHYLSPKHKRK----PLVVQLATIMYSVVMTISLSRLTD-GSSQEYYKDTLDIVRLHELIYNNNTYRITVVISQILTQV 186 Scheffersomyces...
CCE43511     129 LLLYLTQKHRRK----PWLAQLTTIFYSIVTSVLLDRLTK-AAEVEYYDDNLDIIKLNCKVYDNNVYRVLMIITQALTMS 203 Candida parapsi...
EDK43106     153 LLLYLTPKHKRK----PWLTQITTIYYAIVTSVLLNRLTK-AAEQEYYNDILDIIKLHHYLYNTNLYRVLMVLTQVFTMC 227 Lodderomyces el...
Q5AHB5        92 LLLYLSPKYKRK----PLLTQLATVFYAIITTFFLNKLTR-ASEKQYYEDVLDIVELHTILYNNVEYRVLIIIFQVLLLL 166 Candida albicans
XP_002546883  96 LLLYVSPKYKRK----PILTQLATLFYAIVTSYSLSKVTE-TAADQYYRDVLDIIQLHSTLYNRVEYRVLIIIQQVFTMS 170 Candida tropica...
XP_004202267 108 LLLYLSPNHKRK----PVLTQIGTLLYSVLTTLVIVQVTR-TCADQYYDGVLDLPSIQKAAYFNDSYRVVAVFFEVFVHA 182 Pichia farinosa...
Q6BNL3       112 LLMYLSPKHKRK----PWLTQLATVFYSILTTVILSYITD-ESKMQYYADSLNLIQLHNLVYVSYSYRVMVVFSQFFTNL 186 Debaryomyces ha...
CCK68758     288 NWWYIIYFMFhldsnqkrkkvehknhilstiffflvtHRNVTIFTAGVFFLVTDTIFFTFLLWn--------------ET 353 Kazachstania na...
XP_011272748 180 SWVDIMVQISk-------------------------ySYKKKIIICGCILSIINFAIRLAYGFlytrm------dnnePG 228 Wickerhamomyces...
XP_002614600 230 ALVHLGVAMTr-------------------------qTWKRINGAVGLLLTVANLVAMAVRQAqlddfakls-----vkn 279 Clavispora lusi...
XP_001382315 187 AWFQIVLKITk-------------------------tKWKWLTSCYGAVVISAHTAVNIFCQVrynntds--ifdstnAS 239 Scheffersomyces...
CCE43511     204 SWFQIIQRLVr-------------------------lKYKSITSIINFVLMASYIAVYIYFQVvfttrdyishdmqdlTI 258 Candida parapsi...
EDK43106     228 SWFQIIQKITr-------------------------lKYRYTSAVISFIFMGFYIAVFTYYQVsyntqefihnqinrnQT 282 Lodderomyces el...
Q5AHB5       167 SWFQIIQKLAk-------------------------qKYKRIIAIVTGVLMAAFSGCFIYYQVeyntegr-ihmenisGL 220 Candida albicans
XP_002546883 171 AWFQIIVKIAk-------------------------qRYKRIIGMFTLLLMAAYIACSIYYQAscnthgs-idvgadsTE 224 Candida tropica...
XP_004202267 183 SWLQLVVYISk-------------------------qSHKVYMGCFGGVVMIGFTVLHAVYEAskdkaas--kssyekVP 235 Pichia farinosa...
Q6BNL3       187 AWLQIVVHVSk-------------------------lKFKWYSMLVNLILMLAYTVTHSIYEArynnddl-ifnttldSP 240 Debaryomyces ha...
CCK68758     354 VISLRVLYKVSQLSITTMFLGLVGFFLSQ-----KFHFVLEpkrsisqskpnmfeklknmwrnyYDTIPILIYNLVLIvL 428 Kazachstania na...
XP_011272748 229 FKAIKGIHYAFDYLMLIIFICQVARYTIR-----KRQFAYN-----------------------RKTMALAVFSWIIM-L 279 Wickerhamomyces...
XP_002614600 280 pspamfAQHVCQLLIILWLAMLLAYHTLFgtasaPRQVAYS-----------------------RKLVPLASLTWFLV-A 335 Clavispora lusi...
XP_001382315 240 FDRWASARVVIKLMLVVWFGGSLLYYTIVik--nPHKVCYS-----------------------RRLLPLGIFNWFLF-A 293 Scheffersomyces...
CCE43511     259 YHRWDIACVTLRLLVAFWFLGVLAYYTTVmk--nPRKICYS-----------------------RKLLPLAILVWFLF-V 312 Candida parapsi...
EDK43106     283 HYNWSIVRALGRLLIITWFGLNLLHYTVLvk--nPSKICYN-----------------------RKLFPLAFFIWFLI-V 336 Lodderomyces el...
Q5AHB5       221 YLRWKVVRSVMKLILVLWFAGNLLYYTTVvk--nPRKICYC-----------------------KKLLPLAIFNWFLL-I 274 Candida albicans
XP_002546883 225 YHKWNTIRFATNLVIVVWFGGNVLYYTTVik--nPRKICYS-----------------------KKLLPLGMFNWFLI-L 278 Candida tropica...
XP_004202267 236 LTKIRIALVVMKVVIVVWLALNLLYYTIVlk--nPRKISYS-----------------------KKVLRLGICCYVLL-A 289 Pichia farinosa...
Q6BNL3       241 YQRWRLAIHILKLLIMIWFAASILYYTTIik--nPRKICYS-----------------------KKLFPLAISSLSLF-V 294 Debaryomyces ha...
CCK68758     429 LYFTSIFFSAK----NFYISSWKYNIVYFMKLLITVNFWGLISVLRKREATLNRKTILGRKIQNSNKYFVNPH 497 Kazachstania naganishi...
XP_011272748 280 TPFVFCTIDVI----SYSLRTWSSYIFSFAILSSIVVIWEWIHTIRIMELKYERKAVLGRRISNDSflddpmn 348 Wickerhamomyces ciferrii
XP_002614600 336 LQFVMVLLTATlwrnDWLVRAWITFFPYVLSIYVLTCCWEWVHSIRDLESKLERVGMLGRPISMDDIGGFDAS 408 Clavispora lusitaniae ...
XP_001382315 294 LHVVLSILIISlfrdNWLVNTWLFLLPMLIEVIFLTTVWEWVCNIRFLEKRFEMMGVLGRRISLEDIASLHSQ 366 Scheffersomyces stipit...
CCE43511     313 LDIVINILHVSlfrtRWLVRTWLVLIPYLIEIGLLTVIWEWIYNIWILEKRYELMNVLGRRISYEDVVSFKNn 385 Candida parapsilosis
EDK43106     337 LDIVVTILHITlfrhSWLVRTWLILIPYLLEITLLTVVWEWVFNIWILEKRFELMNVLGRRISYEDVVDFKRG 409 Lodderomyces elongispo...
Q5AHB5       275 LHIILGILHISlfedNWLVRTWMVLIPYLIEAILITTVWEWIFNIWVIEKRIELMGVLGRRISIDDVLSIQSl 347 Candida albicans
XP_002546883 279 LHMVLNILHVSlfknNWLIRTWMVLIPYLIELILITTIWEWIFNIWILEKRFELMGVLGRRISIDDVLSIQSN 351 Candida tropicalis MYA...
XP_004202267 290 VQVGLKIFSEKqyrtKWHWNTWIQLILYLIDVSVLATVWEWVYEIEFLERRSELQDMLGRRISFNDVVSFSQD 362 Pichia farinosa CBS 7064
Q6BNL3       295 IHIVANVLSMSlflkDWQVRSWLILISYLIEIGILTAIWEWVYGIEFLEKRYEIMGMLGRRISLNDVISFNLY 367 Debaryomyces hansenii
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