4UM8


Conserved Protein Domain Family
Integrin_b_cyt

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pfam08725: Integrin_b_cyt (This model is not part of the current CDD release)
Integrin beta cytoplasmic domain
Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.
Statistics
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PSSM-Id: 518463
Aligned: 41 rows
Threshold Bit Score: 56.0295
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4UM8_B        731 KLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTY 774 human
XP_686012     722 KGVLYASDLREWRRFEKDRKHEK-TSGTNPLFQNATTTVQNPTF 764
4_pfamImport    1 KLVIYTKDLKEFKKFEIEKKNSKWTDGVSPMFLSATTTIENPTF 44 
XP_015462612  712 KVLLELYDLREYRSFIKAQQQTDWKETNNPLFQGATTTVLNPLH 755
12_pfamImport   1 RISVEVYDRREYQNFLKEQQNVRWKETHNPLFKDATTTVVNPMF 44 
10_pfamImport   1 RVMIEVYDRREYARFEKEKRNAKWTEVNNPLFKSATTTIVNPNF 44 
XP_003216768  730 RVVVDVYDRREFNRFEKECQSAKWNEMSNPLFRSATTTIMNPRY 773
XP_005994348  730 KLVTEVKDRKEYRRFEKEKQKAQWKTNANPLFKEATTTVVNPNF 773
XP_003464027  721 KALTHLSDLREYRRFEKERSKSQWNN-DNPLFKSATTTVMNPKF 763
XP_015214761  727 KLITSWMDLKEYQKFEKEKQKQKWSNADNPLFKGATTTVMNPNF 770
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